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• W2811330735 abstract "Mitochondrial gene expression is largely controlled through post-transcriptional processes including mitochondrial RNA (mt-RNA) processing, modification, decay, and quality control. Defective mitochondrial gene expression results in mitochondrial oxidative phosphorylation (OXPHOS) deficiency and has been implicated in human disease. To fully understand mitochondrial transcription and RNA processing, we performed RNA-seq analyses of mt-RNAs from the fission yeast Schizosaccharomyces pombe RNA-seq analyses show that the abundance of mt-RNAs vary greatly. Analysis of data also reveals mt-RNA processing sites including an unusual RNA cleavage event by mitochondrial tRNA (mt-tRNA) 5'-end processing enzyme RNase P. Additionally, this analysis reveals previously unknown mitochondrial transcripts including the rnpB-derived fragment, mitochondrial small RNAs (mitosRNAs) such as mt-tRNA-derived fragments (mt-tRFs) and mt-tRNA halves, and mt-tRNAs marked with 3'-CCACCA/CCACC in S. pombe Finally, RNA-seq reveals that inactivation of trz2 encoding S. pombe mitochondrial tRNA 3'-end processing enzyme globally impairs mt-tRNA 3'-end processing, inhibits mt-mRNA 5'-end processing, and causes accumulation of unprocessed transcripts, demonstrating the feasibility of using RNA-seq to examine the protein known or predicted to be involved in mt-RNA processing in S. pombe Our work uncovers the complexity of a fungal mitochondrial transcriptome and provides a framework for future studies of mitochondrial gene expression using S. pombe as a model system." @default.
• W2811330735 created "2018-07-10" @default.
• W2811330735 creator A5020115662 @default.
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• W2811330735 creator A5083821702 @default.
• W2811330735 date "2018-06-28" @default.
• W2811330735 modified "2023-10-18" @default.
• W2811330735 title "The <i>S. pombe</i> mitochondrial transcriptome" @default.
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• W2811330735 doi "https://doi.org/10.1261/rna.064477.117" @default.
• W2811330735 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6097661" @default.
• W2811330735 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29954949" @default.
• W2811330735 hasPublicationYear "2018" @default.
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