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• W2811338462 abstract "Alzheimer's disease (AD) is a multifactorial and complex neuropathology that involves impairment of many intricate molecular mechanisms. Despite recent advances, AD pathophysiological characterization remains incomplete, which hampers the development of effective treatments. In fact, currently, there are no effective pharmacological treatments for AD. Integrative strategies such as transcription regulatory network and master regulator analyses exemplify promising new approaches to study complex diseases and may help in the identification of potential pharmacological targets.In this study, we used transcription regulatory network and master regulator analyses on transcriptomic data of human hippocampus to identify transcription factors (TFs) that can potentially act as master regulators in AD. All expression profiles were obtained from the Gene Expression Omnibus database using the GEOquery package. A normal hippocampus transcription factor-centered regulatory network was reconstructed using the ARACNe algorithm. Master regulator analysis and two-tail gene set enrichment analysis were employed to evaluate the inferred regulatory units in AD case-control studies. Finally, we used a connectivity map adaptation to prospect new potential therapeutic interventions by drug repurposing.We identified TFs with already reported involvement in AD, such as ATF2 and PARK2, as well as possible new targets for future investigations, such as CNOT7, CSRNP2, SLC30A9, and TSC22D1. Furthermore, Connectivity Map Analysis adaptation suggested the repositioning of six FDA-approved drugs that can potentially modulate master regulator candidate regulatory units (Cefuroxime, Cyproterone, Dydrogesterone, Metrizamide, Trimethadione, and Vorinostat).Using a transcription factor-centered regulatory network reconstruction we were able to identify several potential molecular targets and six drug candidates for repositioning in AD. Our study provides further support for the use of bioinformatics tools as exploratory strategies in neurodegenerative diseases research, and also provides new perspectives on molecular targets and drug therapies for future investigation and validation in AD." @default.
• W2811338462 created "2018-07-10" @default.
• W2811338462 creator A5017574801 @default.
• W2811338462 creator A5047145594 @default.
• W2811338462 creator A5055042343 @default.
• W2811338462 creator A5064084433 @default.
• W2811338462 date "2018-06-23" @default.
• W2811338462 modified "2023-10-11" @default.
• W2811338462 title "Alzheimer’s disease master regulators analysis: search for potential molecular targets and drug repositioning candidates" @default.
• W2811338462 cites W1085107126 @default.
• W2811338462 cites W1490138151 @default.
• W2811338462 cites W1543387243 @default.
• W2811338462 cites W1552209891 @default.
• W2811338462 cites W1967005522 @default.
• W2811338462 cites W1978955185 @default.
• W2811338462 cites W1980749733 @default.
• W2811338462 cites W1981216611 @default.
• W2811338462 cites W1981817227 @default.
• W2811338462 cites W1982456051 @default.
• W2811338462 cites W1983644675 @default.
• W2811338462 cites W1985308729 @default.
• W2811338462 cites W1989397237 @default.
• W2811338462 cites W1989957637 @default.
• W2811338462 cites W1990048226 @default.
• W2811338462 cites W1996277745 @default.
• W2811338462 cites W1999794509 @default.
• W2811338462 cites W2002181764 @default.
• W2811338462 cites W2003425522 @default.
• W2811338462 cites W2004027050 @default.
• W2811338462 cites W2018813802 @default.
• W2811338462 cites W2019328790 @default.
• W2811338462 cites W2021370614 @default.
• W2811338462 cites W2026970282 @default.
• W2811338462 cites W2027568735 @default.
• W2811338462 cites W2029344309 @default.
• W2811338462 cites W2030187415 @default.
• W2811338462 cites W2041947516 @default.
• W2811338462 cites W2042940752 @default.
• W2811338462 cites W2045360986 @default.
• W2811338462 cites W2048600164 @default.
• W2811338462 cites W2048674295 @default.
• W2811338462 cites W2061116800 @default.
• W2811338462 cites W2062404345 @default.
• W2811338462 cites W2062535312 @default.
• W2811338462 cites W2066399252 @default.
• W2811338462 cites W2068099929 @default.
• W2811338462 cites W207124143 @default.
• W2811338462 cites W2071247399 @default.
• W2811338462 cites W2073156127 @default.
• W2811338462 cites W2079591615 @default.
• W2811338462 cites W2080397078 @default.
• W2811338462 cites W2086396932 @default.
• W2811338462 cites W2088827469 @default.
• W2811338462 cites W2090054406 @default.
• W2811338462 cites W2092010840 @default.
• W2811338462 cites W2097273513 @default.
• W2811338462 cites W2102117809 @default.
• W2811338462 cites W2102471334 @default.
• W2811338462 cites W2104214286 @default.
• W2811338462 cites W2104886236 @default.
• W2811338462 cites W2105210332 @default.
• W2811338462 cites W2106329347 @default.
• W2811338462 cites W2106535424 @default.
• W2811338462 cites W2106565832 @default.
• W2811338462 cites W2108292688 @default.
• W2811338462 cites W2110265246 @default.
• W2811338462 cites W2112541356 @default.
• W2811338462 cites W2115017507 @default.
• W2811338462 cites W2117370894 @default.
• W2811338462 cites W2121604817 @default.
• W2811338462 cites W2122522567 @default.
• W2811338462 cites W2124844317 @default.
• W2811338462 cites W2124940469 @default.
• W2811338462 cites W2138577197 @default.
• W2811338462 cites W2144354758 @default.
• W2811338462 cites W2144463858 @default.
• W2811338462 cites W2146026944 @default.
• W2811338462 cites W2146512944 @default.
• W2811338462 cites W2150730731 @default.
• W2811338462 cites W2154980968 @default.
• W2811338462 cites W2156934474 @default.
• W2811338462 cites W2157232173 @default.
• W2811338462 cites W2158198121 @default.
• W2811338462 cites W2161722802 @default.
• W2811338462 cites W2198703760 @default.
• W2811338462 cites W2267827147 @default.
• W2811338462 cites W2309442902 @default.
• W2811338462 cites W2322494734 @default.
• W2811338462 cites W2391932917 @default.
• W2811338462 cites W2413387607 @default.
• W2811338462 cites W2522768403 @default.
• W2811338462 cites W2556389549 @default.
• W2811338462 cites W2588297910 @default.
• W2811338462 cites W2625921226 @default.
• W2811338462 cites W3011256887 @default.
• W2811338462 cites W3157419554 @default.
• W2811338462 cites W4211028926 @default.
• W2811338462 cites W4230096730 @default.
• W2811338462 cites W4235628601 @default.
• W2811338462 doi "https://doi.org/10.1186/s13195-018-0394-7" @default.

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