FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2811338527> ?p ?o ?g. }

• W2811338527 endingPage "2696" @default.
• W2811338527 startingPage "2685" @default.
• W2811338527 abstract "Abstract The yeast S. cerevisiae senses glucose through Snf3 and Rgt2, transmembrane proteins that generate an intracellular signal in response to glucose that leads to inhibition of the Rgt1 transcriptional repressor and consequently to derepression of HXT genes encoding glucose transporters. Snf3 and Rgt2 are thought to be glucose receptors because they are similar to glucose transporters. In contrast to glucose transporters, they have unusually long C-terminal tails that bind to Mth1 and Std1, paralogous proteins that regulate function of the Rgt1 transcription factor. We show that the C-terminal tail of Rgt2 is not responsible for its inability to transport glucose. To gain insight into how the glucose sensors generate an intracellular signal, we identified RGT2 mutations that cause constitutive signal generation. Most of the mutations alter evolutionarily-conserved amino acids in the transmembrane spanning regions of Rgt2 that are predicted to be involved in maintaining an outward-facing conformation or to be in the substrate binding site. Our analysis of these mutations suggests they cause Rgt2 to adopt inward-facing or occluded conformations that generate the glucose signal. These results support the idea that Rgt2 and Snf3 are glucose receptors that signal in response to binding of extracellular glucose and inform the basis of their signaling." @default.
• W2811338527 created "2018-07-10" @default.
• W2811338527 creator A5000757668 @default.
• W2811338527 creator A5042991989 @default.
• W2811338527 creator A5060550030 @default.
• W2811338527 date "2018-08-01" @default.
• W2811338527 modified "2023-10-16" @default.
• W2811338527 title "Genetic Analysis of Signal Generation by the Rgt2 Glucose Sensor of <i>Saccharomyces cerevisiae</i>" @default.
• W2811338527 cites W1515587017 @default.
• W2811338527 cites W1517699507 @default.
• W2811338527 cites W1803102843 @default.
• W2811338527 cites W1932059283 @default.
• W2811338527 cites W196010343 @default.
• W2811338527 cites W1965675975 @default.
• W2811338527 cites W1975985109 @default.
• W2811338527 cites W1987612677 @default.
• W2811338527 cites W1988608160 @default.
• W2811338527 cites W1993775249 @default.
• W2811338527 cites W2000047924 @default.
• W2811338527 cites W2000350633 @default.
• W2811338527 cites W2013228318 @default.
• W2811338527 cites W2017777783 @default.
• W2811338527 cites W2041946854 @default.
• W2811338527 cites W2046128784 @default.
• W2811338527 cites W2060981193 @default.
• W2811338527 cites W2076349781 @default.
• W2811338527 cites W2086812198 @default.
• W2811338527 cites W2095493331 @default.
• W2811338527 cites W2096985447 @default.
• W2811338527 cites W2118956583 @default.
• W2811338527 cites W2122972109 @default.
• W2811338527 cites W2125583308 @default.
• W2811338527 cites W2134795544 @default.
• W2811338527 cites W2135062809 @default.
• W2811338527 cites W2137002282 @default.
• W2811338527 cites W2140147396 @default.
• W2811338527 cites W2143140464 @default.
• W2811338527 cites W2146546288 @default.
• W2811338527 cites W2161942543 @default.
• W2811338527 cites W2163835152 @default.
• W2811338527 cites W2164952242 @default.
• W2811338527 cites W2168746922 @default.
• W2811338527 cites W2168974130 @default.
• W2811338527 cites W2169333620 @default.
• W2811338527 cites W2178934921 @default.
• W2811338527 cites W2218744117 @default.
• W2811338527 cites W2221809773 @default.
• W2811338527 cites W2336866153 @default.
• W2811338527 cites W2339485220 @default.
• W2811338527 cites W2519870106 @default.
• W2811338527 cites W2625185182 @default.
• W2811338527 cites W2737683399 @default.
• W2811338527 doi "https://doi.org/10.1534/g3.118.200338" @default.
• W2811338527 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6071613" @default.
• W2811338527 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29954842" @default.
• W2811338527 hasPublicationYear "2018" @default.
• W2811338527 type Work @default.
• W2811338527 sameAs 2811338527 @default.
• W2811338527 citedByCount "10" @default.
• W2811338527 countsByYear W28113385272019 @default.
• W2811338527 countsByYear W28113385272021 @default.
• W2811338527 countsByYear W28113385272022 @default.
• W2811338527 crossrefType "journal-article" @default.
• W2811338527 hasAuthorship W2811338527A5000757668 @default.
• W2811338527 hasAuthorship W2811338527A5042991989 @default.
• W2811338527 hasAuthorship W2811338527A5060550030 @default.
• W2811338527 hasBestOaLocation W28113385271 @default.
• W2811338527 hasConcept C104317684 @default.
• W2811338527 hasConcept C134018914 @default.
• W2811338527 hasConcept C150194340 @default.
• W2811338527 hasConcept C158448853 @default.
• W2811338527 hasConcept C161573976 @default.
• W2811338527 hasConcept C170493617 @default.
• W2811338527 hasConcept C186310378 @default.
• W2811338527 hasConcept C24530287 @default.
• W2811338527 hasConcept C2777576037 @default.
• W2811338527 hasConcept C2779222958 @default.
• W2811338527 hasConcept C2779306644 @default.
• W2811338527 hasConcept C28406088 @default.
• W2811338527 hasConcept C55493867 @default.
• W2811338527 hasConcept C73766848 @default.
• W2811338527 hasConcept C79879829 @default.
• W2811338527 hasConcept C86339819 @default.
• W2811338527 hasConcept C86803240 @default.
• W2811338527 hasConcept C89200155 @default.
• W2811338527 hasConcept C95444343 @default.
• W2811338527 hasConceptScore W2811338527C104317684 @default.
• W2811338527 hasConceptScore W2811338527C134018914 @default.
• W2811338527 hasConceptScore W2811338527C150194340 @default.
• W2811338527 hasConceptScore W2811338527C158448853 @default.
• W2811338527 hasConceptScore W2811338527C161573976 @default.
• W2811338527 hasConceptScore W2811338527C170493617 @default.
• W2811338527 hasConceptScore W2811338527C186310378 @default.
• W2811338527 hasConceptScore W2811338527C24530287 @default.
• W2811338527 hasConceptScore W2811338527C2777576037 @default.
• W2811338527 hasConceptScore W2811338527C2779222958 @default.
• W2811338527 hasConceptScore W2811338527C2779306644 @default.
• W2811338527 hasConceptScore W2811338527C28406088 @default.

• next