Matches in SemOpenAlex for { <https://semopenalex.org/work/W2811360463> ?p ?o ?g. }
- W2811360463 endingPage "13" @default.
- W2811360463 startingPage "1" @default.
- W2811360463 abstract "Heart development in mammals is followed by a postnatal decline in cell proliferation and cell renewal from stem cell populations. A better understanding of the developmental changes in cardiac microenvironments occurring during heart maturation will be informative regarding the loss of adult regenerative potential. We reevaluate the adult heart's mitotic potential and the reported adult cardiac stem cell populations, as these are two topics of ongoing debate. The heart's early capacity for cell proliferation driven by progenitors and reciprocal signalling is demonstrated throughout development. The mature heart architecture and environment may be more restrictive on niches that can host progenitor cells. The engraftment issues observed in cardiac stem cell therapy trials using exogenous stem cells may indicate a lack of supporting stem cell niches, while tissue injury adds to a hostile microenvironment for transplanted cells. Engraftment may be improved by preconditioning the cultured stem cells and modulating the microenvironment to host these cells. These prospective areas of further research would benefit from a better understanding of cardiac progenitor interactions with their microenvironment throughout development and may lead to enhanced cardiac niche support for stem cell therapy engraftment." @default.
- W2811360463 created "2018-07-10" @default.
- W2811360463 creator A5034352488 @default.
- W2811360463 creator A5073956506 @default.
- W2811360463 creator A5078524501 @default.
- W2811360463 date "2018-06-24" @default.
- W2811360463 modified "2023-10-14" @default.
- W2811360463 title "Cardiac Stem Cells in the Postnatal Heart: Lessons from Development" @default.
- W2811360463 cites W1418903811 @default.
- W2811360463 cites W1550726172 @default.
- W2811360463 cites W1631250427 @default.
- W2811360463 cites W1669479280 @default.
- W2811360463 cites W1773460394 @default.
- W2811360463 cites W1834747511 @default.
- W2811360463 cites W1950404645 @default.
- W2811360463 cites W1955400364 @default.
- W2811360463 cites W1960983795 @default.
- W2811360463 cites W1964179882 @default.
- W2811360463 cites W1966563415 @default.
- W2811360463 cites W1968732273 @default.
- W2811360463 cites W1970408590 @default.
- W2811360463 cites W1970553523 @default.
- W2811360463 cites W1972943373 @default.
- W2811360463 cites W1974848384 @default.
- W2811360463 cites W1975043059 @default.
- W2811360463 cites W1977025496 @default.
- W2811360463 cites W1980646691 @default.
- W2811360463 cites W1988832870 @default.
- W2811360463 cites W1992521991 @default.
- W2811360463 cites W1992778391 @default.
- W2811360463 cites W1994387772 @default.
- W2811360463 cites W1995697852 @default.
- W2811360463 cites W1998457769 @default.
- W2811360463 cites W1998680808 @default.
- W2811360463 cites W2003035943 @default.
- W2811360463 cites W2005279185 @default.
- W2811360463 cites W2005471059 @default.
- W2811360463 cites W2008434058 @default.
- W2811360463 cites W2010368308 @default.
- W2811360463 cites W2011578758 @default.
- W2811360463 cites W2015644748 @default.
- W2811360463 cites W2016010426 @default.
- W2811360463 cites W2020782061 @default.
- W2811360463 cites W2026749151 @default.
- W2811360463 cites W2028036560 @default.
- W2811360463 cites W2034452944 @default.
- W2811360463 cites W2034998169 @default.
- W2811360463 cites W2036876430 @default.
- W2811360463 cites W2039379704 @default.
- W2811360463 cites W2041112929 @default.
- W2811360463 cites W2042633640 @default.
- W2811360463 cites W2046027917 @default.
- W2811360463 cites W2048692770 @default.
- W2811360463 cites W2050744280 @default.
- W2811360463 cites W2051678354 @default.
- W2811360463 cites W2052538546 @default.
- W2811360463 cites W2053348556 @default.
- W2811360463 cites W2055323054 @default.
- W2811360463 cites W2062298134 @default.
- W2811360463 cites W2065171831 @default.
- W2811360463 cites W2065746091 @default.
- W2811360463 cites W2068945957 @default.
- W2811360463 cites W2069019884 @default.
- W2811360463 cites W2070772918 @default.
- W2811360463 cites W2072162746 @default.
- W2811360463 cites W2075396495 @default.
- W2811360463 cites W2076491580 @default.
- W2811360463 cites W2077806591 @default.
- W2811360463 cites W2080714387 @default.
- W2811360463 cites W2082714048 @default.
- W2811360463 cites W2083421517 @default.
- W2811360463 cites W2088386461 @default.
- W2811360463 cites W2088513836 @default.
- W2811360463 cites W2089247555 @default.
- W2811360463 cites W2090041902 @default.
- W2811360463 cites W2093494581 @default.
- W2811360463 cites W2097834438 @default.
- W2811360463 cites W2098590189 @default.
- W2811360463 cites W2100982253 @default.
- W2811360463 cites W2101986300 @default.
- W2811360463 cites W2108246093 @default.
- W2811360463 cites W2108862261 @default.
- W2811360463 cites W2114430445 @default.
- W2811360463 cites W2117147389 @default.
- W2811360463 cites W2117961743 @default.
- W2811360463 cites W2120609231 @default.
- W2811360463 cites W2120856680 @default.
- W2811360463 cites W2122059700 @default.
- W2811360463 cites W2122421008 @default.
- W2811360463 cites W2123461567 @default.
- W2811360463 cites W2123970448 @default.
- W2811360463 cites W2124955671 @default.
- W2811360463 cites W2125299334 @default.
- W2811360463 cites W2126226576 @default.
- W2811360463 cites W2126747203 @default.
- W2811360463 cites W2127761342 @default.
- W2811360463 cites W2129460482 @default.
- W2811360463 cites W2131463364 @default.