FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2811364897> ?p ?o ?g. }

• W2811364897 endingPage "485.e9" @default.
• W2811364897 startingPage "477" @default.
• W2811364897 abstract "Background & AimsAnorectal manometry is a common test of anal tone and contractility. However, existing measures are often criticized for their poor ability to detect functional differences between individuals with presumably normal sphincter function and individuals with fecal incontinence. We investigated whether new measures, derived from high-resolution anal manometry (HR-ARM), more accurately identify incontinent women with abnormal sphincter function than measures from conventional anal manometry (C-ARM).MethodsWe performed a prospective HR-ARM study of 85 healthy female volunteers (median age 41 years; range 18–68 years) and 403 women with fecal incontinence (median age 55; range 18–91 years) from June 2013 through December 2015. We compared the diagnostic accuracy of conventional measurements of contractility (C-ARM squeeze increment) and tone (C-ARM resting pressure) (the reference standards), with HR-ARM measures (HR-ARM squeeze increment, HR-ARM contractile integral, HR-ARM resting average, HR-ARM rest integral). We also investigated associations between symptom severity and structural sphincter integrity.ResultsWe identified anal hypocontractility in 129 women with fecal incontinence using the C-ARM squeeze increment (32% sensitivity; likelihood ratio, 6.4), in 189 women using the HR-ARM squeeze increment (47% sensitivity; likelihood ratio, 9.4), and in 220 women using the HR-ARM contractile integral (55% sensitivity; likelihood ratio, 11.0). In contrast, HR-ARM measures of anal tone did not particularly outperform conventional measures (31% sensitivity for HR-ARM resting average vs 28% for C-ARM resting pressure). Ninety-eight of the 206 patients with fecal incontinence who were classified as having normal anal function, based on C-ARM measures, were reclassified as having abnormal function based on HR-ARM measures.ConclusionIn a prospective study of healthy women and women with fecal incontinence, we demonstrated that the newly developed HR-ARM contractile integral increased the sensitivity of detection of anal hypocontractility, from 32% to 55%, compared with conventional measurements of squeeze. Anorectal manometry is a common test of anal tone and contractility. However, existing measures are often criticized for their poor ability to detect functional differences between individuals with presumably normal sphincter function and individuals with fecal incontinence. We investigated whether new measures, derived from high-resolution anal manometry (HR-ARM), more accurately identify incontinent women with abnormal sphincter function than measures from conventional anal manometry (C-ARM). We performed a prospective HR-ARM study of 85 healthy female volunteers (median age 41 years; range 18–68 years) and 403 women with fecal incontinence (median age 55; range 18–91 years) from June 2013 through December 2015. We compared the diagnostic accuracy of conventional measurements of contractility (C-ARM squeeze increment) and tone (C-ARM resting pressure) (the reference standards), with HR-ARM measures (HR-ARM squeeze increment, HR-ARM contractile integral, HR-ARM resting average, HR-ARM rest integral). We also investigated associations between symptom severity and structural sphincter integrity. We identified anal hypocontractility in 129 women with fecal incontinence using the C-ARM squeeze increment (32% sensitivity; likelihood ratio, 6.4), in 189 women using the HR-ARM squeeze increment (47% sensitivity; likelihood ratio, 9.4), and in 220 women using the HR-ARM contractile integral (55% sensitivity; likelihood ratio, 11.0). In contrast, HR-ARM measures of anal tone did not particularly outperform conventional measures (31% sensitivity for HR-ARM resting average vs 28% for C-ARM resting pressure). Ninety-eight of the 206 patients with fecal incontinence who were classified as having normal anal function, based on C-ARM measures, were reclassified as having abnormal function based on HR-ARM measures. In a prospective study of healthy women and women with fecal incontinence, we demonstrated that the newly developed HR-ARM contractile integral increased the sensitivity of detection of anal hypocontractility, from 32% to 55%, compared with conventional measurements of squeeze." @default.
• W2811364897 created "2018-07-10" @default.
• W2811364897 creator A5021316721 @default.
• W2811364897 creator A5027198819 @default.
• W2811364897 creator A5029938140 @default.
• W2811364897 creator A5046012946 @default.
• W2811364897 date "2019-02-01" @default.
• W2811364897 modified "2023-09-25" @default.
• W2811364897 title "High-resolution Anorectal Manometry Measures Are More Accurate Than Conventional Measures in Detecting Anal Hypocontractility in Women With Fecal Incontinence" @default.
• W2811364897 cites W1775035413 @default.
• W2811364897 cites W1963702067 @default.
• W2811364897 cites W1978844588 @default.
• W2811364897 cites W1989342881 @default.
• W2811364897 cites W1995413965 @default.
• W2811364897 cites W2000689591 @default.
• W2811364897 cites W2011377946 @default.
• W2811364897 cites W2018553474 @default.
• W2811364897 cites W2018777147 @default.
• W2811364897 cites W2023804350 @default.
• W2811364897 cites W2033208945 @default.
• W2811364897 cites W2035128674 @default.
• W2811364897 cites W2039125441 @default.
• W2811364897 cites W2064028637 @default.
• W2811364897 cites W2064201279 @default.
• W2811364897 cites W2077597113 @default.
• W2811364897 cites W2086768296 @default.
• W2811364897 cites W2099101042 @default.
• W2811364897 cites W2108882655 @default.
• W2811364897 cites W2122732060 @default.
• W2811364897 cites W2136491277 @default.
• W2811364897 cites W2155809406 @default.
• W2811364897 cites W2158037114 @default.
• W2811364897 cites W2212157756 @default.
• W2811364897 cites W2403112374 @default.
• W2811364897 cites W2494381779 @default.
• W2811364897 cites W2528790344 @default.
• W2811364897 cites W2578851124 @default.
• W2811364897 cites W2592818243 @default.
• W2811364897 cites W4210968747 @default.
• W2811364897 doi "https://doi.org/10.1016/j.cgh.2018.06.037" @default.
• W2811364897 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29966707" @default.
• W2811364897 hasPublicationYear "2019" @default.
• W2811364897 type Work @default.
• W2811364897 sameAs 2811364897 @default.
• W2811364897 citedByCount "28" @default.
• W2811364897 countsByYear W28113648972018 @default.
• W2811364897 countsByYear W28113648972019 @default.
• W2811364897 countsByYear W28113648972020 @default.
• W2811364897 countsByYear W28113648972021 @default.
• W2811364897 countsByYear W28113648972022 @default.
• W2811364897 countsByYear W28113648972023 @default.
• W2811364897 crossrefType "journal-article" @default.
• W2811364897 hasAuthorship W2811364897A5021316721 @default.
• W2811364897 hasAuthorship W2811364897A5027198819 @default.
• W2811364897 hasAuthorship W2811364897A5029938140 @default.
• W2811364897 hasAuthorship W2811364897A5046012946 @default.
• W2811364897 hasConcept C108797546 @default.
• W2811364897 hasConcept C126322002 @default.
• W2811364897 hasConcept C126894567 @default.
• W2811364897 hasConcept C141071460 @default.
• W2811364897 hasConcept C164705383 @default.
• W2811364897 hasConcept C188816634 @default.
• W2811364897 hasConcept C2776813522 @default.
• W2811364897 hasConcept C2778510232 @default.
• W2811364897 hasConcept C2779134260 @default.
• W2811364897 hasConcept C2780035688 @default.
• W2811364897 hasConcept C2780691517 @default.
• W2811364897 hasConcept C2781074409 @default.
• W2811364897 hasConcept C2781102422 @default.
• W2811364897 hasConcept C39133596 @default.
• W2811364897 hasConcept C43270747 @default.
• W2811364897 hasConcept C71924100 @default.
• W2811364897 hasConceptScore W2811364897C108797546 @default.
• W2811364897 hasConceptScore W2811364897C126322002 @default.
• W2811364897 hasConceptScore W2811364897C126894567 @default.
• W2811364897 hasConceptScore W2811364897C141071460 @default.
• W2811364897 hasConceptScore W2811364897C164705383 @default.
• W2811364897 hasConceptScore W2811364897C188816634 @default.
• W2811364897 hasConceptScore W2811364897C2776813522 @default.
• W2811364897 hasConceptScore W2811364897C2778510232 @default.
• W2811364897 hasConceptScore W2811364897C2779134260 @default.
• W2811364897 hasConceptScore W2811364897C2780035688 @default.
• W2811364897 hasConceptScore W2811364897C2780691517 @default.
• W2811364897 hasConceptScore W2811364897C2781074409 @default.
• W2811364897 hasConceptScore W2811364897C2781102422 @default.
• W2811364897 hasConceptScore W2811364897C39133596 @default.
• W2811364897 hasConceptScore W2811364897C43270747 @default.
• W2811364897 hasConceptScore W2811364897C71924100 @default.
• W2811364897 hasIssue "3" @default.
• W2811364897 hasLocation W28113648971 @default.
• W2811364897 hasLocation W28113648972 @default.
• W2811364897 hasOpenAccess W2811364897 @default.
• W2811364897 hasPrimaryLocation W28113648971 @default.
• W2811364897 hasRelatedWork W2036459813 @default.
• W2811364897 hasRelatedWork W2039731084 @default.
• W2811364897 hasRelatedWork W2105084944 @default.
• W2811364897 hasRelatedWork W2212157756 @default.
• W2811364897 hasRelatedWork W2789965425 @default.

• next