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- W2811376671 abstract "Maximizing the interseizure period is one of the treatment goals in epilepsy. Factors associated with changes in the interseizure period have not been adequately studied.The objective of this study is to identify factors associated with change in mean interseizure period (MIP) in frequently admitted epilepsy patients. We reviewed clinical notes from the electronic medical records of 303 epilepsy patients who received care at the Partners Healthcare system between 2013-2016 and had 2 or more inpatient encounters within 365 days of the index date. MIP was defined as the average duration between two seizure episodes. The outcome of interest was the change in the MIP between the index date and the 365th day following it. Two reviewers independently determined the MIP. Models were adjusted for age, gender, education, seizure type, Charlson Comorbidity Index Score, encounters with a neurologist, AED type and number of AEDs at index. 86 incident and 217 prevalent epilepsy patients were included. For incident patients, the mean and median change in MIP was 174 days and 179 days, respectively. Every additional year of age was associated with an MIP higher by 2 days (p<0.01). Compared to focal seizures, a mixed seizure type was associated with MIP lower by 102 days (p<0.001). Compared to sodium channel blockers, SV2A binding agents were associated with MIP higher by 132 days (p<0.05). For prevalent patients, the mean and median change in MIP was 30 days and 0 days, respectively. Compared to those who switched their AED type, going from a single generation AED to mixed generation AEDs was associated with 105 less seizure-free days (p<0.01). Among high cost epilepsy patients, change in MIP was associated with age, seizure type and AED characteristics. Efforts to further characterize this population and interventions designed to improve this outcome are needed." @default.
- W2811376671 created "2018-07-10" @default.
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- W2811376671 date "2018-05-01" @default.
- W2811376671 modified "2023-10-04" @default.
- W2811376671 title "Interseizure Interval In Frequently Admitted Epilepsy Patients" @default.
- W2811376671 doi "https://doi.org/10.1016/j.jval.2018.04.926" @default.
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