Matches in SemOpenAlex for { <https://semopenalex.org/work/W2811388045> ?p ?o ?g. }
Showing items 1 to 89 of
89
with 100 items per page.
- W2811388045 endingPage "S228" @default.
- W2811388045 startingPage "S228" @default.
- W2811388045 abstract "OBJECTIVES : Bootstrapping is often used to assess uncertainty in outcomes of randomized controlled trials (RCTs) due to sampling variation and limited sample sizes. Although guidance is available on two-stage bootstrapping for cluster-RCTs, specific guidance is lacking on sampling clusters within bootstrap samples to address the uncertainty in variation across clusters. This study assesses the impact of using different selection approaches to sample clusters in two-stage bootstrapping in a case study on procalcitonin-based antibiotic treatment in IC patients with sepsis. METHODS : The case study was a cluster-RCT including 16 hospitals (4 academic, 12 non-academic) with on average 48 patients per hospital (range n: 1-185). Five cluster sampling approaches were investigated, based on random sampling of: 1) the intended number of patients, 2) 16 hospitals, 3) 16 hospitals maintaining the original ratio academic/non-academic hospitals, 4) as method 2 while maintaining the total number of patients, 5) as method 3 while maintaining the total number of patients. Additionally, a scenario analysis using half of the data was performed. Incremental cost differences and corresponding 95%CIs were determined based on 10,000 bootstrap samples. RESULTS : Different approaches of bootstrapping resulted in variation in the incremental costs per patient (data mean: €16, bootstrap range: €-24 - €183), with approach 5 deviating most from the observed mean incremental cost. 95%CIs also varied in size (smallest 95%CI: €-5,123 - €5,986 [method 5], largest 95%CI: €-5,699 - €6,566 [method 2]). Differences in outcomes were more pronounced when using half of the data. CONCLUSIONS : Using different approaches for sampling clusters in two-stage bootstrapping may influence the mean outcomes and 95%CIs. Determining the most appropriate sampling method based on outcomes and 95%CIs is dependent on the approach for selection used in the real-world trial. When the inclusion strategy is unknown, sensitivity analysis is recommended to assess uncertainty arising from this unknown cluster inclusion process." @default.
- W2811388045 created "2018-07-10" @default.
- W2811388045 creator A5005608514 @default.
- W2811388045 creator A5028950613 @default.
- W2811388045 creator A5042872671 @default.
- W2811388045 creator A5073661308 @default.
- W2811388045 creator A5083295024 @default.
- W2811388045 date "2018-05-01" @default.
- W2811388045 modified "2023-09-27" @default.
- W2811388045 title "The Impact Of Cluster Selection Methods In Two-Stage Bootstrapping To Assess Uncertainty In Health Economic Outcomes In Cluster Randomized Controlled Trials" @default.
- W2811388045 doi "https://doi.org/10.1016/j.jval.2018.04.1544" @default.
- W2811388045 hasPublicationYear "2018" @default.
- W2811388045 type Work @default.
- W2811388045 sameAs 2811388045 @default.
- W2811388045 citedByCount "0" @default.
- W2811388045 crossrefType "journal-article" @default.
- W2811388045 hasAuthorship W2811388045A5005608514 @default.
- W2811388045 hasAuthorship W2811388045A5028950613 @default.
- W2811388045 hasAuthorship W2811388045A5042872671 @default.
- W2811388045 hasAuthorship W2811388045A5073661308 @default.
- W2811388045 hasAuthorship W2811388045A5083295024 @default.
- W2811388045 hasBestOaLocation W28113880451 @default.
- W2811388045 hasConcept C105795698 @default.
- W2811388045 hasConcept C106131492 @default.
- W2811388045 hasConcept C126322002 @default.
- W2811388045 hasConcept C129848803 @default.
- W2811388045 hasConcept C140779682 @default.
- W2811388045 hasConcept C149782125 @default.
- W2811388045 hasConcept C164866538 @default.
- W2811388045 hasConcept C168563851 @default.
- W2811388045 hasConcept C176400912 @default.
- W2811388045 hasConcept C183380357 @default.
- W2811388045 hasConcept C199360897 @default.
- W2811388045 hasConcept C207609745 @default.
- W2811388045 hasConcept C2908647359 @default.
- W2811388045 hasConcept C31972630 @default.
- W2811388045 hasConcept C33923547 @default.
- W2811388045 hasConcept C41008148 @default.
- W2811388045 hasConcept C71924100 @default.
- W2811388045 hasConcept C99454951 @default.
- W2811388045 hasConceptScore W2811388045C105795698 @default.
- W2811388045 hasConceptScore W2811388045C106131492 @default.
- W2811388045 hasConceptScore W2811388045C126322002 @default.
- W2811388045 hasConceptScore W2811388045C129848803 @default.
- W2811388045 hasConceptScore W2811388045C140779682 @default.
- W2811388045 hasConceptScore W2811388045C149782125 @default.
- W2811388045 hasConceptScore W2811388045C164866538 @default.
- W2811388045 hasConceptScore W2811388045C168563851 @default.
- W2811388045 hasConceptScore W2811388045C176400912 @default.
- W2811388045 hasConceptScore W2811388045C183380357 @default.
- W2811388045 hasConceptScore W2811388045C199360897 @default.
- W2811388045 hasConceptScore W2811388045C207609745 @default.
- W2811388045 hasConceptScore W2811388045C2908647359 @default.
- W2811388045 hasConceptScore W2811388045C31972630 @default.
- W2811388045 hasConceptScore W2811388045C33923547 @default.
- W2811388045 hasConceptScore W2811388045C41008148 @default.
- W2811388045 hasConceptScore W2811388045C71924100 @default.
- W2811388045 hasConceptScore W2811388045C99454951 @default.
- W2811388045 hasLocation W28113880451 @default.
- W2811388045 hasLocation W28113880452 @default.
- W2811388045 hasOpenAccess W2811388045 @default.
- W2811388045 hasPrimaryLocation W28113880451 @default.
- W2811388045 hasRelatedWork W1569909498 @default.
- W2811388045 hasRelatedWork W1766520204 @default.
- W2811388045 hasRelatedWork W1967040286 @default.
- W2811388045 hasRelatedWork W1983943461 @default.
- W2811388045 hasRelatedWork W2003580540 @default.
- W2811388045 hasRelatedWork W2030424299 @default.
- W2811388045 hasRelatedWork W2031878292 @default.
- W2811388045 hasRelatedWork W2036045639 @default.
- W2811388045 hasRelatedWork W2055680805 @default.
- W2811388045 hasRelatedWork W2098373960 @default.
- W2811388045 hasRelatedWork W2107513078 @default.
- W2811388045 hasRelatedWork W2121522612 @default.
- W2811388045 hasRelatedWork W2140895629 @default.
- W2811388045 hasRelatedWork W2144038226 @default.
- W2811388045 hasRelatedWork W2527117517 @default.
- W2811388045 hasRelatedWork W2902141488 @default.
- W2811388045 hasRelatedWork W2942788265 @default.
- W2811388045 hasRelatedWork W3015651181 @default.
- W2811388045 hasRelatedWork W3108509173 @default.
- W2811388045 hasRelatedWork W3158999510 @default.
- W2811388045 hasVolume "21" @default.
- W2811388045 isParatext "false" @default.
- W2811388045 isRetracted "false" @default.
- W2811388045 magId "2811388045" @default.
- W2811388045 workType "article" @default.