FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2811450556> ?p ?o ?g. }

• W2811450556 endingPage "3580" @default.
• W2811450556 startingPage "3563" @default.
• W2811450556 abstract "Background and Purpose Activation of the human pregnane X receptor (PXR; NR1I2) has potential therapeutic uses for inflammatory bowel disease (IBD). Imperatorin (IMP), a naturally occurring coumarin, is the main bioactive ingredient of Angelica dahurica Radix, which is regularly used to treat the common cold and intestinal disorders. However, there are no data on the protective effects of IMP against IBD. Experimental Approach The effects of IMP on PXR‐modulated cytochrome P450 3A4 (CYP3A4) expression were assessed using a PXR transactivation assay, a mammalian two‐hybrid assay, a competitive ligand‐binding assay, analysis of CYP3A4 mRNA and protein expression levels and measurement of CYP3A4 activity using a cell‐based reporter gene assay and in vitro model. The inhibitory effects of IMP on NF‐κB activity were evaluated by a reporter assay and NF‐κB p65 nuclear translocation. The anti‐IBD effects of IMP were investigated in a dextran sulphate sodium (DSS)‐induced colitis mouse model. Colon inflammatory cytokines were assessed by elisa . Key Results IMP activated CYP3A4 promoter activity, recruited steroid receptor coactivator 1 to the ligand‐binding domain of PXR and increased the expression and activity of CYP3A4 . PXR knockdown substantially reduced IMP‐induced increase in CYP3A4 expression. Furthermore, IMP‐mediated PXR activation suppressed the nuclear translocation of NF‐κB and down‐regulated LPS‐induced expression of pro‐inflammatory genes. Nevertheless, PXR knockdown partially reduced the IMP‐mediated inhibition of NF‐κB. IMP ameliorated DSS‐induced colitis by PXR/NF‐κB signalling. Conclusions and Implications IMP acts as a PXR agonist to attenuate DSS‐induced colitis by suppression of the NF‐κB‐mediated pro‐inflammatory response in a PXR/NF‐κB‐dependent manner." @default.
• W2811450556 created "2018-07-10" @default.
• W2811450556 creator A5005042481 @default.
• W2811450556 creator A5013091794 @default.
• W2811450556 creator A5014864255 @default.
• W2811450556 creator A5022239790 @default.
• W2811450556 creator A5033633282 @default.
• W2811450556 creator A5035438635 @default.
• W2811450556 creator A5041697028 @default.
• W2811450556 creator A5047214143 @default.
• W2811450556 creator A5050630149 @default.
• W2811450556 creator A5061352971 @default.
• W2811450556 creator A5065408959 @default.
• W2811450556 creator A5073815918 @default.
• W2811450556 creator A5090885358 @default.
• W2811450556 date "2018-07-23" @default.
• W2811450556 modified "2023-10-15" @default.
• W2811450556 title "Activating the pregnane X receptor by imperatorin attenuates dextran sulphate sodium-induced colitis in mice" @default.
• W2811450556 cites W1593555249 @default.
• W2811450556 cites W1872092664 @default.
• W2811450556 cites W1888470382 @default.
• W2811450556 cites W1905497734 @default.
• W2811450556 cites W1964219272 @default.
• W2811450556 cites W1972729313 @default.
• W2811450556 cites W1999559456 @default.
• W2811450556 cites W2006453091 @default.
• W2811450556 cites W2013145525 @default.
• W2811450556 cites W2016185230 @default.
• W2811450556 cites W2019392073 @default.
• W2811450556 cites W2019764042 @default.
• W2811450556 cites W2027010038 @default.
• W2811450556 cites W2030219843 @default.
• W2811450556 cites W2032693719 @default.
• W2811450556 cites W2033122881 @default.
• W2811450556 cites W2033814857 @default.
• W2811450556 cites W2034827757 @default.
• W2811450556 cites W2036988938 @default.
• W2811450556 cites W2037360799 @default.
• W2811450556 cites W2039871782 @default.
• W2811450556 cites W2040104868 @default.
• W2811450556 cites W2044198438 @default.
• W2811450556 cites W2058226245 @default.
• W2811450556 cites W2060041989 @default.
• W2811450556 cites W2061879307 @default.
• W2811450556 cites W2064152895 @default.
• W2811450556 cites W2073714219 @default.
• W2811450556 cites W2091797221 @default.
• W2811450556 cites W2092270405 @default.
• W2811450556 cites W2098568145 @default.
• W2811450556 cites W2102490761 @default.
• W2811450556 cites W2106225676 @default.
• W2811450556 cites W2109291391 @default.
• W2811450556 cites W2113606874 @default.
• W2811450556 cites W2114042463 @default.
• W2811450556 cites W2114507939 @default.
• W2811450556 cites W2132909109 @default.
• W2811450556 cites W2137646911 @default.
• W2811450556 cites W2141597037 @default.
• W2811450556 cites W2146089542 @default.
• W2811450556 cites W2172116519 @default.
• W2811450556 cites W2302524766 @default.
• W2811450556 cites W2307821661 @default.
• W2811450556 cites W2340097563 @default.
• W2811450556 cites W2415327802 @default.
• W2811450556 cites W2500169107 @default.
• W2811450556 cites W2554121987 @default.
• W2811450556 cites W2592128471 @default.
• W2811450556 cites W2605484607 @default.
• W2811450556 cites W2607493369 @default.
• W2811450556 cites W2623145016 @default.
• W2811450556 cites W2763239767 @default.
• W2811450556 cites W2765967569 @default.
• W2811450556 cites W2766306821 @default.
• W2811450556 cites W2767077155 @default.
• W2811450556 cites W2771328536 @default.
• W2811450556 cites W2791419854 @default.
• W2811450556 cites W4211241312 @default.
• W2811450556 doi "https://doi.org/10.1111/bph.14424" @default.
• W2811450556 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6086988" @default.
• W2811450556 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29945292" @default.
• W2811450556 hasPublicationYear "2018" @default.
• W2811450556 type Work @default.
• W2811450556 sameAs 2811450556 @default.
• W2811450556 citedByCount "30" @default.
• W2811450556 countsByYear W28114505562019 @default.
• W2811450556 countsByYear W28114505562020 @default.
• W2811450556 countsByYear W28114505562021 @default.
• W2811450556 countsByYear W28114505562022 @default.
• W2811450556 countsByYear W28114505562023 @default.
• W2811450556 crossrefType "journal-article" @default.
• W2811450556 hasAuthorship W2811450556A5005042481 @default.
• W2811450556 hasAuthorship W2811450556A5013091794 @default.
• W2811450556 hasAuthorship W2811450556A5014864255 @default.
• W2811450556 hasAuthorship W2811450556A5022239790 @default.
• W2811450556 hasAuthorship W2811450556A5033633282 @default.
• W2811450556 hasAuthorship W2811450556A5035438635 @default.
• W2811450556 hasAuthorship W2811450556A5041697028 @default.
• W2811450556 hasAuthorship W2811450556A5047214143 @default.

• next