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• W2811451176 endingPage "701" @default.
• W2811451176 startingPage "695" @default.
• W2811451176 abstract "Recent research has identified a potential role of the hyaluronic acid receptor stabilin-2 (Stab2) in cancer metastasis. Stab2 belongs to a group of scavenger receptors and is responsible for the clearance of more than ten ligands, including hyaluronic acid (HA). In vivo experiments on mice have shown that the absence of Stab2, or its blocking by an antibody, effectively opposes cancer metastasis, which is accompanied by an increase in the level of circulating HA. Knowledge of ligand recognition and signal transduction by Stab2 is limited and no three-dimensional structures of any protein fragments of this receptor have been solved to date. Here, a high-resolution X-ray structure of the seventh FAS1 domain of Stab2 is reported. This structure provides the first insight into the Stab2 structure." @default.
• W2811451176 created "2018-07-10" @default.
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• W2811451176 date "2018-06-27" @default.
• W2811451176 modified "2023-10-17" @default.
• W2811451176 title "Crystal structure of the FAS1 domain of the hyaluronic acid receptor stabilin-2" @default.
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• W2811451176 doi "https://doi.org/10.1107/s2059798318007271" @default.
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• W2811451176 hasPublicationYear "2018" @default.
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