FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2811454477> ?p ?o ?g. }

• W2811454477 endingPage "23572" @default.
• W2811454477 startingPage "23560" @default.
• W2811454477 abstract "Silk is considered to be a potential biomaterial for a wide number of biomedical applications. Silk fibroin (SF) can be retrieved in sufficient quantities from the cocoons produced by silkworms. While it is easy to formulate into scaffolds with favorable mechanical properties, the natural SF does not contain bioactive functions. Spider silk proteins, on the contrary, can be produced in fusion with bioactive protein domains, but the recombinant procedures are expensive, and large-scale production is challenging. We combine the two types of silk to fabricate affordable, functional tissue-engineered constructs for wound-healing applications. Nanofibrous mats and microporous scaffolds made of natural silkworm SF are used as a bulk material that are top-coated with the recombinant spider silk protein (4RepCT) in fusion with a cell-binding motif, antimicrobial peptides, and a growth factor. For this, the inherent silk properties are utilized to form interactions between the two silk types by self-assembly. The intended function, that is, improved cell adhesion, antimicrobial activity, and growth factor stimulation, could be demonstrated for the obtained functionalized silk mats. As a skin prototype, SF scaffolds coated with functionalized silk are cocultured with multiple cell types to demonstrate formation of a bilayered tissue construct with a keratinized epidermal layer under in vitro conditions. The encouraging results support this strategy of fabrication of an affordable bioactive SF-spider silk-based biomaterial for wound dressings and skin substitutes." @default.
• W2811454477 created "2018-07-10" @default.
• W2811454477 creator A5006204265 @default.
• W2811454477 creator A5029253171 @default.
• W2811454477 creator A5067677686 @default.
• W2811454477 creator A5069251404 @default.
• W2811454477 creator A5086164115 @default.
• W2811454477 date "2018-06-25" @default.
• W2811454477 modified "2023-10-17" @default.
• W2811454477 title "Recombinant Spider Silk Functionalized Silkworm Silk Matrices as Potential Bioactive Wound Dressings and Skin Grafts" @default.
• W2811454477 cites W1124641164 @default.
• W2811454477 cites W1174494744 @default.
• W2811454477 cites W1423191041 @default.
• W2811454477 cites W16631805 @default.
• W2811454477 cites W1880461483 @default.
• W2811454477 cites W1965324241 @default.
• W2811454477 cites W1981986412 @default.
• W2811454477 cites W1989021197 @default.
• W2811454477 cites W1989734247 @default.
• W2811454477 cites W1993903078 @default.
• W2811454477 cites W1997947168 @default.
• W2811454477 cites W2010004473 @default.
• W2811454477 cites W2010539886 @default.
• W2811454477 cites W2010901608 @default.
• W2811454477 cites W2019711191 @default.
• W2811454477 cites W2021977065 @default.
• W2811454477 cites W2022301246 @default.
• W2811454477 cites W2026230444 @default.
• W2811454477 cites W2029773366 @default.
• W2811454477 cites W2037810763 @default.
• W2811454477 cites W2039944519 @default.
• W2811454477 cites W2053992512 @default.
• W2811454477 cites W2054602599 @default.
• W2811454477 cites W2056064788 @default.
• W2811454477 cites W2056097887 @default.
• W2811454477 cites W2060077653 @default.
• W2811454477 cites W2066427639 @default.
• W2811454477 cites W2078668750 @default.
• W2811454477 cites W2080207900 @default.
• W2811454477 cites W2083877661 @default.
• W2811454477 cites W2091651320 @default.
• W2811454477 cites W2098923926 @default.
• W2811454477 cites W2110541415 @default.
• W2811454477 cites W2112145198 @default.
• W2811454477 cites W2115317412 @default.
• W2811454477 cites W2120472250 @default.
• W2811454477 cites W2132477880 @default.
• W2811454477 cites W2133602801 @default.
• W2811454477 cites W2157908104 @default.
• W2811454477 cites W2217592530 @default.
• W2811454477 cites W2340760643 @default.
• W2811454477 cites W2530008486 @default.
• W2811454477 cites W2530589003 @default.
• W2811454477 cites W2561436450 @default.
• W2811454477 cites W2586512251 @default.
• W2811454477 cites W2588991598 @default.
• W2811454477 cites W2619101941 @default.
• W2811454477 cites W2746712943 @default.
• W2811454477 cites W2761724645 @default.
• W2811454477 cites W2761940021 @default.
• W2811454477 cites W2767280943 @default.
• W2811454477 cites W2773926684 @default.
• W2811454477 cites W2776391973 @default.
• W2811454477 cites W2793002331 @default.
• W2811454477 doi "https://doi.org/10.1021/acsami.8b05853" @default.
• W2811454477 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29940099" @default.
• W2811454477 hasPublicationYear "2018" @default.
• W2811454477 type Work @default.
• W2811454477 sameAs 2811454477 @default.
• W2811454477 citedByCount "56" @default.
• W2811454477 countsByYear W28114544772018 @default.
• W2811454477 countsByYear W28114544772019 @default.
• W2811454477 countsByYear W28114544772020 @default.
• W2811454477 countsByYear W28114544772021 @default.
• W2811454477 countsByYear W28114544772022 @default.
• W2811454477 countsByYear W28114544772023 @default.
• W2811454477 crossrefType "journal-article" @default.
• W2811454477 hasAuthorship W2811454477A5006204265 @default.
• W2811454477 hasAuthorship W2811454477A5029253171 @default.
• W2811454477 hasAuthorship W2811454477A5067677686 @default.
• W2811454477 hasAuthorship W2811454477A5069251404 @default.
• W2811454477 hasAuthorship W2811454477A5086164115 @default.
• W2811454477 hasConcept C122302759 @default.
• W2811454477 hasConcept C126348684 @default.
• W2811454477 hasConcept C136229726 @default.
• W2811454477 hasConcept C159985019 @default.
• W2811454477 hasConcept C171250308 @default.
• W2811454477 hasConcept C192562407 @default.
• W2811454477 hasConcept C203014093 @default.
• W2811454477 hasConcept C206767735 @default.
• W2811454477 hasConcept C2776847223 @default.
• W2811454477 hasConcept C2778414984 @default.
• W2811454477 hasConcept C2780269544 @default.
• W2811454477 hasConcept C2780431358 @default.
• W2811454477 hasConcept C49892992 @default.
• W2811454477 hasConcept C71924100 @default.
• W2811454477 hasConcept C86803240 @default.
• W2811454477 hasConceptScore W2811454477C122302759 @default.

• next