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- W2811461718 endingPage "941" @default.
- W2811461718 startingPage "931" @default.
- W2811461718 abstract "Introduction: Recent advances in prognostication as well as management of Follicular Lymphoma (FL) are moving to personalized approach.Areas covered: Prognostic scores as well as consolidated and innovative therapeutic approaches are evaluated according to the various presentation modalities. For asymptomatic, low-tumor burden FL, a ‘watch and wait’ policy is currently the first-choice approach, although possible alternatives are discussed. Early stage FL may be treated with local radiotherapy although the role of minimal residual disease in possible additional agents should be determined. The first line treatment for symptomatic FL is chemo-immunotherapy followed by two years maintenance therapy with anti-CD20 monoclonal antibodies. A deeper knowledge of FL biology has opened new perspectives regarding the timing of therapy and has offered new targets for the development of novel agents that aim to change the therapeutic scenario of FL management.Expert commentary: The introduction of novel agents could question the incurability of FL and change the therapeutic goal from prolonging the complete remission state to eradicating the disease in young/fit patients, as well as improving quality of life in elderly/unfit patients. In the near future, combining new biologic agents and adoptive cell therapies could help in achieving these aims." @default.
- W2811461718 created "2018-07-10" @default.
- W2811461718 creator A5006030842 @default.
- W2811461718 creator A5009431453 @default.
- W2811461718 creator A5031563326 @default.
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- W2811461718 creator A5061089197 @default.
- W2811461718 creator A5061807415 @default.
- W2811461718 creator A5063661249 @default.
- W2811461718 creator A5081247845 @default.
- W2811461718 date "2018-07-16" @default.
- W2811461718 modified "2023-10-14" @default.
- W2811461718 title "Current and future therapeutic approaches for the treatment of follicular lymphoma" @default.
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