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- W2811489543 abstract "There are significant differences in the properties of individual antihypertensive medications in terms of side effects, costs, and dosing complexity among other factors. Accordingly, there are differences in how individual antihypertensive medications impact medication adherence. In this chapter, we review the literature establishing an association between antihypertensive drug class and medication adherence, with adherence typically highest for angiotensin converting enzyme inhibitors and angiotensin receptor blockers and lowest for diuretics and beta-blockers. We also review the mechanisms through which properties of the principal classes of antihypertensive drugs can influence medication adherence. There is also evidence of substantial differences in how antihypertensive medications affect individual patients, with some medications resulting in greater blood pressure reduction and others in lower tolerability. We discuss how this heterogeneity of treatment effect may lead to differential impacts of antihypertensive drugs on medication adherence among individual patients. We conclude by suggesting approaches to preventing adverse effects of antihypertensive drugs on medication adherence in clinical practice. From a clinician’s perspective, we emphasize personalized, patient-centered approaches, including N-of-1 trials, for optimizing the selection and maintenance of medications with the best opportunity for long-term adherence." @default.
- W2811489543 created "2018-07-10" @default.
- W2811489543 creator A5008479772 @default.
- W2811489543 creator A5058865250 @default.
- W2811489543 date "2018-01-01" @default.
- W2811489543 modified "2023-10-01" @default.
- W2811489543 title "The Impact of Antihypertensive Drugs on Adherence" @default.
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- W2811489543 doi "https://doi.org/10.1007/978-3-319-76593-8_12" @default.
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