Matches in SemOpenAlex for { <https://semopenalex.org/work/W2811496108> ?p ?o ?g. }
- W2811496108 abstract "The alternative pathway is a continuously active surveillance arm of the complement system, and it can also enhance complement activation initiated by the classical and the lectin pathways. Various membrane-bound and plasma regulatory proteins control the activation of the potentially deleterious complement system. Among the regulators, the plasma glycoprotein factor H (FH) is the main inhibitor of the alternative pathway and its powerful amplification loop. FH belongs to a protein family that also includes FH-like protein 1 and five factor H-related (FHR-1 to FHR-5) proteins. Genetic variants and abnormal rearrangements involving the FH protein family have been linked to numerous systemic and organ-specific diseases, including age-related macular degeneration, and the renal pathologies atypical hemolytic uremic syndrome, C3 glomerulopathies, and IgA nephropathy. This review covers the known and recently emerged ligands and interactions of the human FH family proteins associated with disease and discuss the very recent experimental data that suggest FH-antagonistic and complement-activating functions for the FHR proteins." @default.
- W2811496108 created "2018-07-10" @default.
- W2811496108 creator A5003491962 @default.
- W2811496108 creator A5011905794 @default.
- W2811496108 creator A5016484576 @default.
- W2811496108 creator A5081352308 @default.
- W2811496108 date "2018-07-12" @default.
- W2811496108 modified "2023-10-15" @default.
- W2811496108 title "Self-Damage Caused by Dysregulation of the Complement Alternative Pathway: Relevance of the Factor H Protein Family" @default.
- W2811496108 cites W1484225284 @default.
- W2811496108 cites W1491837037 @default.
- W2811496108 cites W1492385697 @default.
- W2811496108 cites W1492585433 @default.
- W2811496108 cites W1529745308 @default.
- W2811496108 cites W1532545931 @default.
- W2811496108 cites W1534759813 @default.
- W2811496108 cites W1535259997 @default.
- W2811496108 cites W1569686393 @default.
- W2811496108 cites W1580898910 @default.
- W2811496108 cites W1600561684 @default.
- W2811496108 cites W1606380774 @default.
- W2811496108 cites W1615621128 @default.
- W2811496108 cites W1660960311 @default.
- W2811496108 cites W1671290836 @default.
- W2811496108 cites W1675921820 @default.
- W2811496108 cites W1857401373 @default.
- W2811496108 cites W1871202872 @default.
- W2811496108 cites W1928260253 @default.
- W2811496108 cites W1963906871 @default.
- W2811496108 cites W1965130348 @default.
- W2811496108 cites W1965721063 @default.
- W2811496108 cites W1966820620 @default.
- W2811496108 cites W1969658114 @default.
- W2811496108 cites W1970738865 @default.
- W2811496108 cites W1971052994 @default.
- W2811496108 cites W1972147302 @default.
- W2811496108 cites W1975809414 @default.
- W2811496108 cites W1976736415 @default.
- W2811496108 cites W1979236525 @default.
- W2811496108 cites W1980493655 @default.
- W2811496108 cites W1983426760 @default.
- W2811496108 cites W1986909164 @default.
- W2811496108 cites W1988416417 @default.
- W2811496108 cites W1988847663 @default.
- W2811496108 cites W1988891719 @default.
- W2811496108 cites W1990568953 @default.
- W2811496108 cites W1993383034 @default.
- W2811496108 cites W1997599954 @default.
- W2811496108 cites W1997746165 @default.
- W2811496108 cites W1997761753 @default.
- W2811496108 cites W2000822340 @default.
- W2811496108 cites W2003796699 @default.
- W2811496108 cites W2006264045 @default.
- W2811496108 cites W2006877316 @default.
- W2811496108 cites W2008607429 @default.
- W2811496108 cites W2010448151 @default.
- W2811496108 cites W2010518173 @default.
- W2811496108 cites W2010717419 @default.
- W2811496108 cites W2015242897 @default.
- W2811496108 cites W2017568050 @default.
- W2811496108 cites W2017695801 @default.
- W2811496108 cites W2023080159 @default.
- W2811496108 cites W2024064075 @default.
- W2811496108 cites W2025421051 @default.
- W2811496108 cites W2025678142 @default.
- W2811496108 cites W2026784781 @default.
- W2811496108 cites W2029886021 @default.
- W2811496108 cites W2035563294 @default.
- W2811496108 cites W2035726643 @default.
- W2811496108 cites W2036436658 @default.
- W2811496108 cites W2036607489 @default.
- W2811496108 cites W2036694775 @default.
- W2811496108 cites W2037699290 @default.
- W2811496108 cites W2038375867 @default.
- W2811496108 cites W2042777883 @default.
- W2811496108 cites W2043835217 @default.
- W2811496108 cites W2048681283 @default.
- W2811496108 cites W2053560271 @default.
- W2811496108 cites W2054101977 @default.
- W2811496108 cites W2056617843 @default.
- W2811496108 cites W2057807842 @default.
- W2811496108 cites W2058782937 @default.
- W2811496108 cites W2059500112 @default.
- W2811496108 cites W2061626915 @default.
- W2811496108 cites W2062097745 @default.
- W2811496108 cites W2063798785 @default.
- W2811496108 cites W2067053006 @default.
- W2811496108 cites W2067200826 @default.
- W2811496108 cites W2068743916 @default.
- W2811496108 cites W2071731444 @default.
- W2811496108 cites W2074286693 @default.
- W2811496108 cites W2074330772 @default.
- W2811496108 cites W2077144266 @default.
- W2811496108 cites W2079362912 @default.
- W2811496108 cites W2079543475 @default.
- W2811496108 cites W2079648119 @default.
- W2811496108 cites W2079953346 @default.
- W2811496108 cites W2080636057 @default.
- W2811496108 cites W2081737697 @default.
- W2811496108 cites W2082883706 @default.