Matches in SemOpenAlex for { <https://semopenalex.org/work/W2811591230> ?p ?o ?g. }
- W2811591230 endingPage "1784" @default.
- W2811591230 startingPage "1768" @default.
- W2811591230 abstract "After fracture, mesenchymal stem cells (MSCs) and growth factors migrate into the fracture callus to exert their biological actions. Previous studies have indicated that dynamic loading induced tissue deformation and interstitial fluid flow could produce a biomechanical environment which significantly affects the healing outcomes. However, the fundamental relationship between the various loading regimes and different healing outcomes has not still been fully understood. In this study, we present an integrated computational model to investigate the effect of dynamic loading on early stage of bone fracture healing. The model takes into account cell and growth factor transport under dynamic loading, and mechanical stimuli mediated MSC differentiation and tissue production. The developed model was firstly validated by the available experimental data, and then implemented to identify the loading regimes that produce the optimal healing outcomes. Our results demonstrated that dynamic loading enhances MSC and growth factor transport in a spatially dependent manner. For example, compared to free diffusion, dynamic loading could significantly increase MSCs concentration in endosteal zone; and chondrogenic growth factors in both cortical and periosteal zones in callus. Furthermore, there could be an optimal dynamic loading regime (e.g. 10% strain at 1 Hz) which could potentially significant enhance endochondral ossification." @default.
- W2811591230 created "2018-07-19" @default.
- W2811591230 creator A5000065569 @default.
- W2811591230 creator A5040451589 @default.
- W2811591230 creator A5048450294 @default.
- W2811591230 creator A5054640457 @default.
- W2811591230 creator A5055066066 @default.
- W2811591230 date "2018-07-09" @default.
- W2811591230 modified "2023-10-14" @default.
- W2811591230 title "Role of Dynamic Loading on Early Stage of Bone Fracture Healing" @default.
- W2811591230 cites W1762036144 @default.
- W2811591230 cites W1916156238 @default.
- W2811591230 cites W1964733232 @default.
- W2811591230 cites W1964963328 @default.
- W2811591230 cites W1966260373 @default.
- W2811591230 cites W1966646960 @default.
- W2811591230 cites W1970237590 @default.
- W2811591230 cites W1970957687 @default.
- W2811591230 cites W1972729657 @default.
- W2811591230 cites W1973186017 @default.
- W2811591230 cites W1978226596 @default.
- W2811591230 cites W1978496495 @default.
- W2811591230 cites W1978839709 @default.
- W2811591230 cites W1979137563 @default.
- W2811591230 cites W1983943515 @default.
- W2811591230 cites W1985298426 @default.
- W2811591230 cites W1986893291 @default.
- W2811591230 cites W1987137464 @default.
- W2811591230 cites W1988189846 @default.
- W2811591230 cites W1991778851 @default.
- W2811591230 cites W1997299213 @default.
- W2811591230 cites W1997794453 @default.
- W2811591230 cites W2000052205 @default.
- W2811591230 cites W2002425495 @default.
- W2811591230 cites W2009494180 @default.
- W2811591230 cites W2010751506 @default.
- W2811591230 cites W2029621921 @default.
- W2811591230 cites W2030913739 @default.
- W2811591230 cites W2033964259 @default.
- W2811591230 cites W2036380033 @default.
- W2811591230 cites W2040323277 @default.
- W2811591230 cites W2044811076 @default.
- W2811591230 cites W2049072682 @default.
- W2811591230 cites W2049416108 @default.
- W2811591230 cites W2057504093 @default.
- W2811591230 cites W2060372448 @default.
- W2811591230 cites W2063158203 @default.
- W2811591230 cites W2069636601 @default.
- W2811591230 cites W2070429786 @default.
- W2811591230 cites W2071448073 @default.
- W2811591230 cites W2074618458 @default.
- W2811591230 cites W2075415804 @default.
- W2811591230 cites W2083407704 @default.
- W2811591230 cites W2084595614 @default.
- W2811591230 cites W2085975835 @default.
- W2811591230 cites W2090936021 @default.
- W2811591230 cites W2094576343 @default.
- W2811591230 cites W2097396736 @default.
- W2811591230 cites W2101296090 @default.
- W2811591230 cites W2111019735 @default.
- W2811591230 cites W2111312751 @default.
- W2811591230 cites W2120761640 @default.
- W2811591230 cites W2121213250 @default.
- W2811591230 cites W2122944897 @default.
- W2811591230 cites W2126800859 @default.
- W2811591230 cites W2130168564 @default.
- W2811591230 cites W2130867526 @default.
- W2811591230 cites W2136456374 @default.
- W2811591230 cites W2141841781 @default.
- W2811591230 cites W2160469740 @default.
- W2811591230 cites W2162281037 @default.
- W2811591230 cites W2182108454 @default.
- W2811591230 cites W2187323772 @default.
- W2811591230 cites W2200751703 @default.
- W2811591230 cites W2339217045 @default.
- W2811591230 cites W2499034705 @default.
- W2811591230 cites W2988868023 @default.
- W2811591230 cites W4235657941 @default.
- W2811591230 doi "https://doi.org/10.1007/s10439-018-2083-x" @default.
- W2811591230 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29987542" @default.
- W2811591230 hasPublicationYear "2018" @default.
- W2811591230 type Work @default.
- W2811591230 sameAs 2811591230 @default.
- W2811591230 citedByCount "38" @default.
- W2811591230 countsByYear W28115912302019 @default.
- W2811591230 countsByYear W28115912302020 @default.
- W2811591230 countsByYear W28115912302021 @default.
- W2811591230 countsByYear W28115912302022 @default.
- W2811591230 countsByYear W28115912302023 @default.
- W2811591230 crossrefType "journal-article" @default.
- W2811591230 hasAuthorship W2811591230A5000065569 @default.
- W2811591230 hasAuthorship W2811591230A5040451589 @default.
- W2811591230 hasAuthorship W2811591230A5048450294 @default.
- W2811591230 hasAuthorship W2811591230A5054640457 @default.
- W2811591230 hasAuthorship W2811591230A5055066066 @default.
- W2811591230 hasBestOaLocation W28115912302 @default.
- W2811591230 hasConcept C105702510 @default.
- W2811591230 hasConcept C136229726 @default.