FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2812842076> ?p ?o ?g. }

• W2812842076 abstract "Abstract Most metazoan embryos commence development with rapid cleavages without zygotic gene expression and their genome activation is delayed until the mid-blastula transition (MBT). However, a set of genes escape global repression during the extremely fast cell cycles, which lack gap phases and their transcription is activated before the MBT. Here we describe the formation and the spatio-temporal dynamics of a distinct transcription compartment, which encompasses the earliest detectable transcription during the first wave of genome activation. Simultaneous 4D imaging of expression of pri-miR430 and zinc finger genes by a novel, native transcription imaging approach reveals a pair of shared transcription compartments regulated by homolog chromosome organisation. These nuclear compartments carry the majority of nascent RNAs and transcriptionally active Polymerase II, are depleted of compact chromatin and represent the main sites for detectable transcription before MBT. We demonstrate that transcription occurs in the S-phase of the cleavage cycles and that the gradual slowing of these cell cycles are permissive to transcription before global genome activation. We propose that the demonstrated transcription compartment is part of the regulatory architecture of nucleus organisation, and provides a transcriptionally competent, supporting environment to facilitate early escape from the general nuclear repression before global genome activation." @default.
• W2812842076 created "2018-07-19" @default.
• W2812842076 creator A5000742925 @default.
• W2812842076 creator A5012268284 @default.
• W2812842076 creator A5015560950 @default.
• W2812842076 creator A5017404099 @default.
• W2812842076 creator A5029509549 @default.
• W2812842076 creator A5030706381 @default.
• W2812842076 creator A5031183317 @default.
• W2812842076 creator A5031980265 @default.
• W2812842076 creator A5032176542 @default.
• W2812842076 creator A5035777674 @default.
• W2812842076 creator A5046312886 @default.
• W2812842076 creator A5046758897 @default.
• W2812842076 creator A5057028381 @default.
• W2812842076 creator A5063537122 @default.
• W2812842076 creator A5082369012 @default.
• W2812842076 creator A5090930917 @default.
• W2812842076 date "2018-07-13" @default.
• W2812842076 modified "2023-10-18" @default.
• W2812842076 title "A cell cycle-coordinated nuclear compartment for Polymerase II transcription encompasses the earliest gene expression before global genome activation" @default.
• W2812842076 cites W1866869277 @default.
• W2812842076 cites W1944716249 @default.
• W2812842076 cites W1961074127 @default.
• W2812842076 cites W1964215562 @default.
• W2812842076 cites W1964259728 @default.
• W2812842076 cites W1977786555 @default.
• W2812842076 cites W1979315404 @default.
• W2812842076 cites W1987659565 @default.
• W2812842076 cites W1988745695 @default.
• W2812842076 cites W1996507133 @default.
• W2812842076 cites W2005416403 @default.
• W2812842076 cites W2006328220 @default.
• W2812842076 cites W2028630156 @default.
• W2812842076 cites W2031928671 @default.
• W2812842076 cites W2038254017 @default.
• W2812842076 cites W2040463804 @default.
• W2812842076 cites W2040891939 @default.
• W2812842076 cites W2047755766 @default.
• W2812842076 cites W2049868101 @default.
• W2812842076 cites W2050345155 @default.
• W2812842076 cites W2054598634 @default.
• W2812842076 cites W2061015334 @default.
• W2812842076 cites W2072247333 @default.
• W2812842076 cites W2075899471 @default.
• W2812842076 cites W2080646543 @default.
• W2812842076 cites W2081180790 @default.
• W2812842076 cites W2083260329 @default.
• W2812842076 cites W2097065948 @default.
• W2812842076 cites W2098218231 @default.
• W2812842076 cites W2103354991 @default.
• W2812842076 cites W2103431676 @default.
• W2812842076 cites W2108445577 @default.
• W2812842076 cites W2115685806 @default.
• W2812842076 cites W2119731001 @default.
• W2812842076 cites W2120772351 @default.
• W2812842076 cites W2127540003 @default.
• W2812842076 cites W2127942857 @default.
• W2812842076 cites W2130652821 @default.
• W2812842076 cites W2130963936 @default.
• W2812842076 cites W2131725400 @default.
• W2812842076 cites W2132926880 @default.
• W2812842076 cites W2136145671 @default.
• W2812842076 cites W2140382281 @default.
• W2812842076 cites W2151687078 @default.
• W2812842076 cites W2162316859 @default.
• W2812842076 cites W2169456326 @default.
• W2812842076 cites W2185073681 @default.
• W2812842076 cites W2189955651 @default.
• W2812842076 cites W2202141609 @default.
• W2812842076 cites W2500686989 @default.
• W2812842076 cites W2549864964 @default.
• W2812842076 cites W2553711301 @default.
• W2812842076 cites W2560889465 @default.
• W2812842076 cites W2562927701 @default.
• W2812842076 cites W2572798406 @default.
• W2812842076 cites W2594035655 @default.
• W2812842076 cites W2597274540 @default.
• W2812842076 cites W2603000633 @default.
• W2812842076 cites W2604200375 @default.
• W2812842076 cites W2605545409 @default.
• W2812842076 cites W2612926554 @default.
• W2812842076 cites W2614131742 @default.
• W2812842076 cites W2727471508 @default.
• W2812842076 cites W2790814744 @default.
• W2812842076 doi "https://doi.org/10.1101/366468" @default.
• W2812842076 hasPublicationYear "2018" @default.
• W2812842076 type Work @default.
• W2812842076 sameAs 2812842076 @default.
• W2812842076 citedByCount "1" @default.
• W2812842076 countsByYear W28128420762017 @default.
• W2812842076 crossrefType "posted-content" @default.
• W2812842076 hasAuthorship W2812842076A5000742925 @default.
• W2812842076 hasAuthorship W2812842076A5012268284 @default.
• W2812842076 hasAuthorship W2812842076A5015560950 @default.
• W2812842076 hasAuthorship W2812842076A5017404099 @default.
• W2812842076 hasAuthorship W2812842076A5029509549 @default.
• W2812842076 hasAuthorship W2812842076A5030706381 @default.
• W2812842076 hasAuthorship W2812842076A5031183317 @default.
• W2812842076 hasAuthorship W2812842076A5031980265 @default.

• next