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- W2812875538 abstract "Context/ObjectiveTo evaluate the impact of long-term nitrofurantoin for UTI prophylaxis in veterans with SCI.DesignMatched pairs study.SettingVeterans cared for at VA facilities from 10/1/2012-9/30/2013.ParticipantsVeterans.Interventionsn/a.Outcomes measuresUTI, positive urine cultures, resistant cultures.MethodsCases receiving long-term nitrofurantoin (≥90 days supply) were matched to controls by facility. Controls were patients who did not receive long-term nitrofurantoin with a history of ≥3 positive urine cultures and at least one diagnosis of UTI or asymptomatic bacteriuria in the previous year.Results122 SCI cases were identified and matched to 196 controls. After adjusting for differences in baseline demographic characteristics, UTIs were less frequent in cases (OR = 0.60 [95% CI 0.44-0.72]). Cases had a greater mean number of days between positive urine cultures as compared to controls (<0.0001). Cases were more likely to have isolates resistant to nitrofurantoin (P ≤ 0.0001); however, the frequency of multi-drug resistant organisms isolated from the urine was not significantly different.ConclusionsLong-term prescription of nitrofurantoin may reduce UTIs in veterans with SCI and there is no evidence that it promotes multi-drug resistance. Future prospective studies should be conducted prior to incorporating routine use of long-term nitrofurantoin into clinical care." @default.
- W2812875538 created "2018-07-19" @default.
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- W2812875538 date "2018-07-09" @default.
- W2812875538 modified "2023-09-27" @default.
- W2812875538 title "Long-term prescribing of nitrofurantoin for urinary tract infections (UTI) in veterans with spinal cord injury (SCI)" @default.
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- W2812875538 doi "https://doi.org/10.1080/10790268.2018.1488096" @default.
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