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- W2813426232 abstract "目的研究急性坏死性胰腺炎(ANP)大鼠肺组织细胞间粘附分子1(ICAM-1)mRNA的表达情况及其与肺损伤的关系.方法将33只Wistar大鼠随机分为正常对照组和胰腺炎不同时间点(1、4、12和24h)各组,用逆行胰胆管注射方法制备ANP模型.采用逆转录聚合酶链反应法检测ANP大鼠肺组织中ICAM-1 mRNA表达,同时观察肺组织髓过氧化物酶(MPO)及病理改变.结果造模ANP 1h后大鼠肺组织中ICAM-1 mRNA(0.82±0.03)比正常对照组(0.41±0.04)的表达水平高(P＜0.05),并持续升高至12h及24h(分别为1.17±0.05及 1.11±0.04),同时伴有肺组织病理损害,其严重程度与ICAM-1 mRNA表达、MPO及肺MPO与ICAM-1 mRNA表达均呈正相关,相关系数分别为0.85、0.85及0.96(P＜0.05).结论 ANP大鼠早期肺组织中ICAM-1 mRNA呈过度表达,肺损伤严重程度与ICAM-1 mRNA表达的高低有关.肺组织中ICAM-1过度表达及中性粒细胞浸润是ANP肺损害发生的原因之一." @default.
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- W2813426232 date "2003-01-25" @default.
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- W2813426232 title "Intrapulmonary expression of intercellular adhesion molecule-1 gene in rats with acute necrotizing pancreatitis" @default.
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