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- W2813883312 endingPage "10070" @default.
- W2813883312 startingPage "10061" @default.
- W2813883312 abstract "Protein therapeutics is a rapidly growing segment of the pharmaceutical market. Currently, the majority of protein therapeutics are manufactured in mammalian cells for their ability to generate safe and efficacious human-like glycoproteins. The high cost of using mammalian cells for manufacturing has motivated a constant search for alternative host platforms. Insect cells have begun to emerge as a promising candidate, largely due to the development of the baculovirus expression vector system. While there are continuing efforts to improve insect-baculovirus expression for producing protein therapeutics, key limitations including cell lysis and the lack of homogeneous humanized glycosylation still remain. The field has started to see a movement toward virus-less gene expression approaches, notably the use of clustered regularly interspaced short palindromic repeats to address these shortcomings. This review highlights recent technological advances that are realizing the transformative potential of insect cells for the manufacturing and development of protein therapeutics." @default.
- W2813883312 created "2018-07-19" @default.
- W2813883312 creator A5036332505 @default.
- W2813883312 creator A5069201271 @default.
- W2813883312 creator A5070146412 @default.
- W2813883312 creator A5079698319 @default.
- W2813883312 date "2018-07-09" @default.
- W2813883312 modified "2023-10-16" @default.
- W2813883312 title "The Coming Age of Insect Cells for Manufacturing and Development of Protein Therapeutics" @default.
- W2813883312 cites W1066175468 @default.
- W2813883312 cites W1483226634 @default.
- W2813883312 cites W1484868003 @default.
- W2813883312 cites W1493565145 @default.
- W2813883312 cites W1510498019 @default.
- W2813883312 cites W1513147618 @default.
- W2813883312 cites W1516646376 @default.
- W2813883312 cites W1581899920 @default.
- W2813883312 cites W1915519529 @default.
- W2813883312 cites W1946566829 @default.
- W2813883312 cites W1964072345 @default.
- W2813883312 cites W1967472093 @default.
- W2813883312 cites W1969932115 @default.
- W2813883312 cites W1972684176 @default.
- W2813883312 cites W1972744160 @default.
- W2813883312 cites W1972879829 @default.
- W2813883312 cites W1974720495 @default.
- W2813883312 cites W1975351631 @default.
- W2813883312 cites W1975933455 @default.
- W2813883312 cites W1983897121 @default.
- W2813883312 cites W1984985875 @default.
- W2813883312 cites W1985140325 @default.
- W2813883312 cites W1987402374 @default.
- W2813883312 cites W1987963312 @default.
- W2813883312 cites W1988191110 @default.
- W2813883312 cites W1991402484 @default.
- W2813883312 cites W1992271352 @default.
- W2813883312 cites W1995815978 @default.
- W2813883312 cites W2004010477 @default.
- W2813883312 cites W2005931422 @default.
- W2813883312 cites W2015820134 @default.
- W2813883312 cites W2024026760 @default.
- W2813883312 cites W2025629542 @default.
- W2813883312 cites W2027694180 @default.
- W2813883312 cites W2027894892 @default.
- W2813883312 cites W2030209236 @default.
- W2813883312 cites W2031893105 @default.
- W2813883312 cites W2033310968 @default.
- W2813883312 cites W2033706830 @default.
- W2813883312 cites W2033966179 @default.
- W2813883312 cites W2035000078 @default.
- W2813883312 cites W2039705224 @default.
- W2813883312 cites W2040846175 @default.
- W2813883312 cites W2041226094 @default.
- W2813883312 cites W2041727225 @default.
- W2813883312 cites W2042963714 @default.
- W2813883312 cites W2043268934 @default.
- W2813883312 cites W2047553434 @default.
- W2813883312 cites W2050480410 @default.
- W2813883312 cites W2054243692 @default.
- W2813883312 cites W2060658253 @default.
- W2813883312 cites W2062575193 @default.
- W2813883312 cites W2064129235 @default.
- W2813883312 cites W2065616233 @default.
- W2813883312 cites W2073318439 @default.
- W2813883312 cites W2075470662 @default.
- W2813883312 cites W2076228786 @default.
- W2813883312 cites W2078343378 @default.
- W2813883312 cites W2080340512 @default.
- W2813883312 cites W2080871194 @default.
- W2813883312 cites W2081306620 @default.
- W2813883312 cites W2084584909 @default.
- W2813883312 cites W2086145691 @default.
- W2813883312 cites W2091677148 @default.
- W2813883312 cites W2092533132 @default.
- W2813883312 cites W2092545878 @default.
- W2813883312 cites W2096556262 @default.
- W2813883312 cites W2098563031 @default.
- W2813883312 cites W2102831372 @default.
- W2813883312 cites W2104400426 @default.
- W2813883312 cites W2111777671 @default.
- W2813883312 cites W2114773348 @default.
- W2813883312 cites W2115330624 @default.
- W2813883312 cites W2115525058 @default.
- W2813883312 cites W2116519871 @default.
- W2813883312 cites W2117728762 @default.
- W2813883312 cites W2121343569 @default.
- W2813883312 cites W2121490089 @default.
- W2813883312 cites W2123639682 @default.
- W2813883312 cites W2129915992 @default.
- W2813883312 cites W2136728173 @default.
- W2813883312 cites W2137813507 @default.
- W2813883312 cites W2138096293 @default.
- W2813883312 cites W2138223986 @default.
- W2813883312 cites W2138993899 @default.
- W2813883312 cites W2142447995 @default.
- W2813883312 cites W2149961418 @default.
- W2813883312 cites W2152708819 @default.
- W2813883312 cites W2155339588 @default.