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• W2815355812 abstract "Lactate accumulation has been observed in the brain with intracerebral hemorrhage (ICH). However, the outcome of lactate accumulation has not been well characterized. Here, we report that lactate accumulation contributes to angiogenesis and neurogenesis in ICH. In the first set of the experiment, a rat model of ICH was induced by injecting collagenase into the brain. The effects of lactate accumulation on the neurological function, apoptosis, and numbers of newborn endothelial cells and neurons, as well as the proliferation-associated signaling pathway, were evaluated in the rat brain. In the second set, exogenous l-lactate was infused into intact rat brains so that its effects could be further assessed. Following ICH, lactate accumulated around the hematoma; the numbers of PCNA+/vWF+ nuclei and PCNA+/DCX+ cells were significantly increased compared with the numbers in the Sham group. Moreover, ICH induced translocation of nuclear factor-kappa B (NF-κB) p65 into the nucleus, resulting in a notable upregulation of VEGF and bFGF mRNAs and proteins compared with the levels in the Sham controls. Administration of a lactate dehydrogenase inhibitor dramatically inhibited these effects, decreased the vascular density, and aggravated neurological severity scores and apoptosis after ICH. After exogenous l-lactate infusion, the numbers of PCNA+/vWF+ nuclei and PCNA+/DCX+ cells were strikingly increased compared with the numbers in the Sham controls. In addition, lactate facilitated NF-κB translocation to induce increased transcription of VEGF and bFGF. Co-infusion with an NF-κB inhibitor significantly inhibited these effects. These data suggest that lactate potentiates angiogenesis and neurogenesis by activating the NF-κB signaling pathway following ICH. After a blood vessel bursts in the brain, lactate, a metabolic intermediary, accumulates around the bleeding site to increase new blood vessels and neurons. A team led by Tao Tang and Yang Wang at Central South University in Changsha, China, experimentally induced brain hemorrhage in rats and examined the effects of lactate in the brain. They showed that this metabolic signaling molecule protected against cell death and increased expression of growth factors involved in blood vessel formation and neural regeneration. Inhibiting lactate blocked these effects, while infusing exogenous lactate into the rat brains enhanced them. The findings suggest that lactate promotes angiogenesis and neurogenesis in experimental intracerebral hemorrhage." @default.
• W2815355812 created "2018-07-19" @default.
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• W2815355812 date "2018-07-01" @default.
• W2815355812 modified "2023-10-18" @default.
• W2815355812 title "Lactate potentiates angiogenesis and neurogenesis in experimental intracerebral hemorrhage" @default.
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• W2815355812 doi "https://doi.org/10.1038/s12276-018-0113-2" @default.
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