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- W2815617934 endingPage "e0200268" @default.
- W2815617934 startingPage "e0200268" @default.
- W2815617934 abstract "Serotonin (5-HT) acts as both a morphogenetic factor during early embryonic development and a neuromodulator of circuit plasticity in the mature brain. Dysregulation of serotonin signaling during critical periods is involved in developmental neurological disorders, such as schizophrenia and autism. In this study we focused on the consequences of defect reelin signaling for the development of the brainstem serotonergic raphe system. We observed that reelin signaling components are expressed by serotonergic neurons during the critical period of their lateral migration. Further, we found that reelin signaling is important for the normal migration of rostral, but not caudal hindbrain raphe nuclei and that reelin deficiency results in the malformation of the paramedian raphe nucleus and the lateral wings of the dorsal raphe nuclei. Additionally, we showed that serotonergic neurons projections to laminated brain structures were severely altered. With this study, we propose that the perturbation of canonical reelin signaling interferes with the orientation of tangentially, but not radially, migrating brainstem 5-HT neurons. Our results open the window for further studies on the interaction of reelin and serotonin and the pathogenesis of neurodevelopmental disorders." @default.
- W2815617934 created "2018-07-19" @default.
- W2815617934 creator A5014885754 @default.
- W2815617934 creator A5020280426 @default.
- W2815617934 creator A5026520425 @default.
- W2815617934 creator A5032217372 @default.
- W2815617934 creator A5040936222 @default.
- W2815617934 creator A5064076179 @default.
- W2815617934 date "2018-07-12" @default.
- W2815617934 modified "2023-10-14" @default.
- W2815617934 title "Reelin controls the positioning of brainstem serotonergic raphe neurons" @default.
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