FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W281595089> ?p ?o ?g. }

• W281595089 endingPage "e0127062" @default.
• W281595089 startingPage "e0127062" @default.
• W281595089 abstract "Six weeks of zidovudine (ZDV) is recommended for postnatal prophylaxis of HIV-exposed infants, but combination antiretrovirals are indicated if HIV transmission risk is increased. We investigated the frequency and severity of adverse events (AE) in infants receiving multiple drug prophylaxis compared to ZDV alone. In this retrospective review of 148 HIV-exposed uninfected infants born between 1997-2009, we determined clinical and laboratory AE that occurred between days of life 8-42. Thirty-six infants received combination prophylaxis; among those, a three-drug regimen containing ZDV, lamivudine, and nevirapine was most common (53%). Rates of laboratory AE grade ≥1 were as follows for the combination prophylaxis and ZDV alone groups, respectively: neutropenia 55% and 39%; anemia 50% and 39%; thrombocytopenia 0 and 3%; elevated aspartate aminotransferase 3% and 3%; elevated alanine aminotransferase 0 and 1%; hyperbilirubinemia 19% and 42%. Anemia occurred more frequently in infants who received three-drug prophylaxis compared to infants who received ZDV alone (63% vs. 39%, p = 0.04); all anemia AE were grade 1 or 2 in the three-drug prophylaxis group. Overall, 75% of infants on combination prophylaxis and 66% of infants on ZDV alone developed grade ≥1 AE (p = 0.32), and 17% of infants in either group developed grade ≥3 AE. Stavudine was substituted for ZDV in 23 infants due to anemia or neutropenia. After this antiretroviral change, 50% of evaluable infants demonstrated improvement in AE grade, and 25% had no change. In conclusion, low grade anemia, neutropenia, and hyperbilirubinemia occurred frequently regardless of the prophylactic regimen, but serious AE were uncommon. Although most AE were typical of ZDV toxicity, the combination of ZDV with lamivudine and nevirapine resulted in an increased frequency of low-grade anemia. Further studies are needed to identify prophylactic regimens with less toxicity for infants born to HIV-infected mothers." @default.
• W281595089 created "2016-06-24" @default.
• W281595089 creator A5008401627 @default.
• W281595089 creator A5010772046 @default.
• W281595089 creator A5019730302 @default.
• W281595089 creator A5022306134 @default.
• W281595089 creator A5030423526 @default.
• W281595089 creator A5051264386 @default.
• W281595089 creator A5053010060 @default.
• W281595089 creator A5079455826 @default.
• W281595089 creator A5087886593 @default.
• W281595089 creator A5087998279 @default.
• W281595089 date "2015-05-22" @default.
• W281595089 modified "2023-10-03" @default.
• W281595089 title "Serious Adverse Events Are Uncommon with Combination Neonatal Antiretroviral Prophylaxis: A Retrospective Case Review" @default.
• W281595089 cites W1953234161 @default.
• W281595089 cites W1963976980 @default.
• W281595089 cites W1967503024 @default.
• W281595089 cites W1968607461 @default.
• W281595089 cites W2009367857 @default.
• W281595089 cites W2020735972 @default.
• W281595089 cites W2021788072 @default.
• W281595089 cites W2026974242 @default.
• W281595089 cites W2027377022 @default.
• W281595089 cites W2031438145 @default.
• W281595089 cites W2041095047 @default.
• W281595089 cites W2052049408 @default.
• W281595089 cites W2054937433 @default.
• W281595089 cites W2059762016 @default.
• W281595089 cites W2063949146 @default.
• W281595089 cites W2120255324 @default.
• W281595089 cites W2127457135 @default.
• W281595089 cites W2130560337 @default.
• W281595089 cites W2141357379 @default.
• W281595089 cites W2162321323 @default.
• W281595089 cites W2170308202 @default.
• W281595089 cites W2319193381 @default.
• W281595089 cites W257126896 @default.
• W281595089 cites W4230671476 @default.
• W281595089 cites W4297851374 @default.
• W281595089 doi "https://doi.org/10.1371/journal.pone.0127062" @default.
• W281595089 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4441417" @default.
• W281595089 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26000984" @default.
• W281595089 hasPublicationYear "2015" @default.
• W281595089 type Work @default.
• W281595089 sameAs 281595089 @default.
• W281595089 citedByCount "12" @default.
• W281595089 countsByYear W2815950892016 @default.
• W281595089 countsByYear W2815950892017 @default.
• W281595089 countsByYear W2815950892018 @default.
• W281595089 countsByYear W2815950892019 @default.
• W281595089 countsByYear W2815950892021 @default.
• W281595089 countsByYear W2815950892023 @default.
• W281595089 crossrefType "journal-article" @default.
• W281595089 hasAuthorship W281595089A5008401627 @default.
• W281595089 hasAuthorship W281595089A5010772046 @default.
• W281595089 hasAuthorship W281595089A5019730302 @default.
• W281595089 hasAuthorship W281595089A5022306134 @default.
• W281595089 hasAuthorship W281595089A5030423526 @default.
• W281595089 hasAuthorship W281595089A5051264386 @default.
• W281595089 hasAuthorship W281595089A5053010060 @default.
• W281595089 hasAuthorship W281595089A5079455826 @default.
• W281595089 hasAuthorship W281595089A5087886593 @default.
• W281595089 hasAuthorship W281595089A5087998279 @default.
• W281595089 hasBestOaLocation W2815950891 @default.
• W281595089 hasConcept C126322002 @default.
• W281595089 hasConcept C142462285 @default.
• W281595089 hasConcept C187212893 @default.
• W281595089 hasConcept C197934379 @default.
• W281595089 hasConcept C203014093 @default.
• W281595089 hasConcept C2522874641 @default.
• W281595089 hasConcept C2776694085 @default.
• W281595089 hasConcept C2777063308 @default.
• W281595089 hasConcept C2777869810 @default.
• W281595089 hasConcept C2778248108 @default.
• W281595089 hasConcept C2779130552 @default.
• W281595089 hasConcept C2779889181 @default.
• W281595089 hasConcept C2780216070 @default.
• W281595089 hasConcept C2780593183 @default.
• W281595089 hasConcept C2780727368 @default.
• W281595089 hasConcept C2781413609 @default.
• W281595089 hasConcept C2993143319 @default.
• W281595089 hasConcept C3013748606 @default.
• W281595089 hasConcept C71924100 @default.
• W281595089 hasConcept C90924648 @default.
• W281595089 hasConceptScore W281595089C126322002 @default.
• W281595089 hasConceptScore W281595089C142462285 @default.
• W281595089 hasConceptScore W281595089C187212893 @default.
• W281595089 hasConceptScore W281595089C197934379 @default.
• W281595089 hasConceptScore W281595089C203014093 @default.
• W281595089 hasConceptScore W281595089C2522874641 @default.
• W281595089 hasConceptScore W281595089C2776694085 @default.
• W281595089 hasConceptScore W281595089C2777063308 @default.
• W281595089 hasConceptScore W281595089C2777869810 @default.
• W281595089 hasConceptScore W281595089C2778248108 @default.
• W281595089 hasConceptScore W281595089C2779130552 @default.
• W281595089 hasConceptScore W281595089C2779889181 @default.
• W281595089 hasConceptScore W281595089C2780216070 @default.

• next