FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2816930172> ?p ?o ?g. }

• W2816930172 endingPage "132" @default.
• W2816930172 startingPage "119" @default.
• W2816930172 abstract "The RNA helicase UP-FRAMESHIFT (UPF1) is a key factor of nonsense-mediated decay (NMD), a mRNA decay pathway involved in RNA quality control and in the fine-tuning of gene expression. UPF1 recruits UPF2 and UPF3 to constitute the NMD core complex, which is conserved across eukaryotes. No other components of UPF1-containing ribonucleoproteins (RNPs) are known in plants, despite its key role in regulating gene expression. Here, we report the identification of a large set of proteins that co-purify with the Arabidopsis UPF1, either in an RNA-dependent or RNA-independent manner. We found that like UPF1, several of its co-purifying proteins have a dual localization in the cytosol and in P-bodies, which are dynamic structures formed by the condensation of translationally repressed mRNPs. Interestingly, more than half of the proteins of the UPF1 interactome also co-purify with DCP5, a conserved translation repressor also involved in P-body formation. We identified a terminal nucleotidyltransferase, ribonucleases and several RNA helicases among the most significantly enriched proteins co-purifying with both UPF1 and DCP5. Among these, RNA helicases are the homologs of DDX6/Dhh1, known as translation repressors in humans and yeast, respectively. Overall, this study reports a large set of proteins associated with the Arabidopsis UPF1 and DCP5, two components of P-bodies, and reveals an extensive interaction network between RNA degradation and translation repression factors. Using this resource, we identified five hitherto unknown components of P-bodies in plants, pointing out the value of this dataset for the identification of proteins potentially involved in translation repression and/or RNA degradation." @default.
• W2816930172 created "2018-07-19" @default.
• W2816930172 creator A5001794530 @default.
• W2816930172 creator A5012931823 @default.
• W2816930172 creator A5015280980 @default.
• W2816930172 creator A5015668613 @default.
• W2816930172 creator A5025269258 @default.
• W2816930172 creator A5029821080 @default.
• W2816930172 creator A5047500964 @default.
• W2816930172 creator A5056581970 @default.
• W2816930172 creator A5089402623 @default.
• W2816930172 date "2018-08-01" @default.
• W2816930172 modified "2023-09-25" @default.
• W2816930172 title "The UPF1 interactome reveals interaction networks between RNA degradation and translation repression factors in Arabidopsis" @default.
• W2816930172 cites W1603331969 @default.
• W2816930172 cites W1603435192 @default.
• W2816930172 cites W1969118812 @default.
• W2816930172 cites W1971723670 @default.
• W2816930172 cites W1981887230 @default.
• W2816930172 cites W1985847018 @default.
• W2816930172 cites W1987050385 @default.
• W2816930172 cites W1990900965 @default.
• W2816930172 cites W1993544709 @default.
• W2816930172 cites W1995737813 @default.
• W2816930172 cites W2011442568 @default.
• W2816930172 cites W2019696945 @default.
• W2816930172 cites W2022976260 @default.
• W2816930172 cites W2023178295 @default.
• W2816930172 cites W2032747482 @default.
• W2816930172 cites W2040466913 @default.
• W2816930172 cites W2041322170 @default.
• W2816930172 cites W2042934384 @default.
• W2816930172 cites W2045565555 @default.
• W2816930172 cites W2051842708 @default.
• W2816930172 cites W2056782574 @default.
• W2816930172 cites W2059921194 @default.
• W2816930172 cites W2062012048 @default.
• W2816930172 cites W2070419622 @default.
• W2816930172 cites W2074873035 @default.
• W2816930172 cites W2078656428 @default.
• W2816930172 cites W2079810511 @default.
• W2816930172 cites W2087793363 @default.
• W2816930172 cites W2097938918 @default.
• W2816930172 cites W2101555571 @default.
• W2816930172 cites W2104256272 @default.
• W2816930172 cites W2114104545 @default.
• W2816930172 cites W2115452664 @default.
• W2816930172 cites W2116841494 @default.
• W2816930172 cites W2117691109 @default.
• W2816930172 cites W2121341109 @default.
• W2816930172 cites W2121773790 @default.
• W2816930172 cites W2121982512 @default.
• W2816930172 cites W2127278857 @default.
• W2816930172 cites W2130628675 @default.
• W2816930172 cites W2133465414 @default.
• W2816930172 cites W2133585560 @default.
• W2816930172 cites W2133902192 @default.
• W2816930172 cites W2135804883 @default.
• W2816930172 cites W2136785377 @default.
• W2816930172 cites W2137618565 @default.
• W2816930172 cites W2138310356 @default.
• W2816930172 cites W2141220224 @default.
• W2816930172 cites W2143355329 @default.
• W2816930172 cites W2151230050 @default.
• W2816930172 cites W2158178674 @default.
• W2816930172 cites W2158217645 @default.
• W2816930172 cites W2158584001 @default.
• W2816930172 cites W2161558477 @default.
• W2816930172 cites W2162195906 @default.
• W2816930172 cites W2166964088 @default.
• W2816930172 cites W2167527034 @default.
• W2816930172 cites W2169066667 @default.
• W2816930172 cites W2195136000 @default.
• W2816930172 cites W2291970866 @default.
• W2816930172 cites W2520188071 @default.
• W2816930172 cites W2531933060 @default.
• W2816930172 cites W2550329754 @default.
• W2816930172 cites W2559883499 @default.
• W2816930172 cites W2606353482 @default.
• W2816930172 cites W2610258637 @default.
• W2816930172 cites W2617657422 @default.
• W2816930172 cites W2747298891 @default.
• W2816930172 cites W2759609596 @default.
• W2816930172 cites W2766829811 @default.
• W2816930172 cites W2767613320 @default.
• W2816930172 cites W2771046199 @default.
• W2816930172 cites W2791043224 @default.
• W2816930172 doi "https://doi.org/10.1111/tpj.14022" @default.
• W2816930172 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29983000" @default.
• W2816930172 hasPublicationYear "2018" @default.
• W2816930172 type Work @default.
• W2816930172 sameAs 2816930172 @default.
• W2816930172 citedByCount "44" @default.
• W2816930172 countsByYear W28169301722018 @default.
• W2816930172 countsByYear W28169301722019 @default.
• W2816930172 countsByYear W28169301722020 @default.
• W2816930172 countsByYear W28169301722021 @default.
• W2816930172 countsByYear W28169301722022 @default.

• next