Matches in SemOpenAlex for { <https://semopenalex.org/work/W281736185> ?p ?o ?g. }
Showing items 1 to 68 of
68
with 100 items per page.
- W281736185 endingPage "71" @default.
- W281736185 startingPage "262" @default.
- W281736185 abstract "The negative inotropic actions of 12 beta-adrenergic blocking agents, all of which are aryloxyisopropylaminopropanols were studied in isolated left atria from reserpinized guinea-pig hearts. At concentrations between 10 and 1000 microM, all these drugs, with the exception of atenolol, reduced the contractile force by more than 40%. The following order of potency, as measured as ED40, was thus derived:propranolol, alprenolol, D-25, Ko 707, pindolol, oxprenolol, Kö 592, befunolol, metoprolol, Kö 1313, acebutolol and atenolol. On the other hand, the order of the octanol/water partition coefficient (P) was as follows: propranolol, alprenolol, D-25, Kö 707, Kö 592, oxprenolol, befunolol, acebutolol, metoprolol, pindolol, Kö 1313 and atenolol. A significant correlation was found between log l/ED40 and log P. The results indicate that hydrophobicity is a major determinant for the negative inotropic effects of these beta-adrenergic agents." @default.
- W281736185 created "2016-06-24" @default.
- W281736185 creator A5001831730 @default.
- W281736185 creator A5065337816 @default.
- W281736185 creator A5080266991 @default.
- W281736185 creator A5081540651 @default.
- W281736185 date "1981-08-01" @default.
- W281736185 modified "2023-09-23" @default.
- W281736185 title "Negative inotropic effects and the hydrophobicity of beta-adrenergic blocking agents." @default.
- W281736185 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6118107" @default.
- W281736185 hasPublicationYear "1981" @default.
- W281736185 type Work @default.
- W281736185 sameAs 281736185 @default.
- W281736185 citedByCount "5" @default.
- W281736185 crossrefType "journal-article" @default.
- W281736185 hasAuthorship W281736185A5001831730 @default.
- W281736185 hasAuthorship W281736185A5065337816 @default.
- W281736185 hasAuthorship W281736185A5080266991 @default.
- W281736185 hasAuthorship W281736185A5081540651 @default.
- W281736185 hasConcept C126322002 @default.
- W281736185 hasConcept C155710745 @default.
- W281736185 hasConcept C185592680 @default.
- W281736185 hasConcept C2776271928 @default.
- W281736185 hasConcept C2776525901 @default.
- W281736185 hasConcept C2776663762 @default.
- W281736185 hasConcept C2778151854 @default.
- W281736185 hasConcept C2778499207 @default.
- W281736185 hasConcept C2778679995 @default.
- W281736185 hasConcept C2780275434 @default.
- W281736185 hasConcept C2781280847 @default.
- W281736185 hasConcept C71924100 @default.
- W281736185 hasConcept C84393581 @default.
- W281736185 hasConcept C98274493 @default.
- W281736185 hasConceptScore W281736185C126322002 @default.
- W281736185 hasConceptScore W281736185C155710745 @default.
- W281736185 hasConceptScore W281736185C185592680 @default.
- W281736185 hasConceptScore W281736185C2776271928 @default.
- W281736185 hasConceptScore W281736185C2776525901 @default.
- W281736185 hasConceptScore W281736185C2776663762 @default.
- W281736185 hasConceptScore W281736185C2778151854 @default.
- W281736185 hasConceptScore W281736185C2778499207 @default.
- W281736185 hasConceptScore W281736185C2778679995 @default.
- W281736185 hasConceptScore W281736185C2780275434 @default.
- W281736185 hasConceptScore W281736185C2781280847 @default.
- W281736185 hasConceptScore W281736185C71924100 @default.
- W281736185 hasConceptScore W281736185C84393581 @default.
- W281736185 hasConceptScore W281736185C98274493 @default.
- W281736185 hasIssue "2" @default.
- W281736185 hasLocation W2817361851 @default.
- W281736185 hasOpenAccess W281736185 @default.
- W281736185 hasPrimaryLocation W2817361851 @default.
- W281736185 hasRelatedWork W1970006678 @default.
- W281736185 hasRelatedWork W2052460192 @default.
- W281736185 hasRelatedWork W2059305261 @default.
- W281736185 hasRelatedWork W2074336918 @default.
- W281736185 hasRelatedWork W2170398504 @default.
- W281736185 hasRelatedWork W2276917216 @default.
- W281736185 hasRelatedWork W2417967039 @default.
- W281736185 hasRelatedWork W281736185 @default.
- W281736185 hasRelatedWork W93637233 @default.
- W281736185 hasRelatedWork W2116821205 @default.
- W281736185 hasVolume "252" @default.
- W281736185 isParatext "false" @default.
- W281736185 isRetracted "false" @default.
- W281736185 magId "281736185" @default.
- W281736185 workType "article" @default.