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• W281738356 abstract "The Mas protooncogene encodes a G protein-coupled receptor with the common seven transmembrane domains, expressed mainly in the testis and brain. We provided evidence that Mas is a functional angiotensin-(1-7) receptor and can interact with the angiotensin II type 1 (AT1) receptor. The gene is transcriptionally regulated during development in the brain and testis, but its structure was unresolved. In this study we used 5'- and 3'-RACE, RT-PCR, and RNase-protection assays to elucidate the complete Mas gene structure and organization. We identified 12 exons in the mouse Mas gene with 11 in the 5' untranslated mRNA, which can be alternatively spliced. We also showed that Mas transcription can start from 4 tissue-specific promoters, whereby testis-specific Mas mRNA is transcribed from two upstream promoters, and the expression of Mas in the brain starts from two downstream promoters. Alternative splicing and multiple promoter usage result in at least 12 Mas transcripts in which different 5' untranslated regions are fused to a common coding sequence. Moreover, termination of Mas mRNA is regulated by two different polyadenylation signals. The gene spans approximately 27 kb, and the longest detected mRNA contains 2,451 bp. Thus, our results characterize the Mas protooncogene as the gene with the most complex gene structure of all described members of the gene family coding for G protein-coupled receptors." @default.
• W281738356 created "2016-06-24" @default.
• W281738356 creator A5009553066 @default.
• W281738356 creator A5018088496 @default.
• W281738356 creator A5039371456 @default.
• W281738356 creator A5059936166 @default.
• W281738356 date "2015-09-01" @default.
• W281738356 modified "2023-09-23" @default.
• W281738356 title "Multiple non-coding exons and alternative splicing in the mouse Mas protooncogene" @default.
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• W281738356 doi "https://doi.org/10.1016/j.gene.2015.05.043" @default.
• W281738356 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26003294" @default.
• W281738356 hasPublicationYear "2015" @default.
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