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- W2817388 abstract "Atherosclerosis is a disease of medium and large-sized arteries that claims more lives in the western world than any other disease. Atherosclerosis is characterized by changes in the content and distribution of hyaluronan. For example, the hyaluronan content of human atherosclerotic plaques generally decreases with increasing severity of atherosclerosis. Hyaluronan is also present in regions of atherosclerotic lesions that contain inflammatory cells such as macrophages and lymphocytes Consistent with this, the extravasation of leukocytes from the blood into the vascular wall involves hyaluronan anchored to the surface of the endothelial cells by CD44 or Receptor for hyaluronan-mediated motility (RHAMM), and is mediated by CD44 on the surface of the leukocytes. Further, hyaluronan also increases when human vessels are subjected to balloon angioplasty during surgical procedures to open blocked arteries. Hyaluronan is a prominent component of arterial smooth muscle cells (ASMC), rich in both stented and nonstented human restenotic arteries. Hyaluronan is a critical extracellular matrix (ECM) component in atherosclerosis and restenosis. Not only does it contribute to blood vessel wall thickening, but also effects the biology of the vascular cells involved in vascular lesion progression. Attention needs to be given to understand the mechanism(s) responsible for hyaluronan accumulation in blood vessel disease, as well as the molecular and signaling events that regulate the impact of hyaluronan on vascular cell phenotype. Targeting hyaluronan and/or associated molecules would seem to be a reasonable strategy to limit or prevent atherosclerosis and restenosis." @default.
- W2817388 created "2016-06-24" @default.
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- W2817388 date "2004-01-01" @default.
- W2817388 modified "2023-09-24" @default.
- W2817388 title "Hyaluronan in Atherosclerosis and Restenosis" @default.
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- W2817388 doi "https://doi.org/10.1016/b978-008044382-9/50045-5" @default.
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