FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2817941793> ?p ?o ?g. }

• W2817941793 endingPage "1465" @default.
• W2817941793 startingPage "1454" @default.
• W2817941793 abstract "Innate immunity contributes to the pathogenesis of inflammatory bowel disease (IBD). However, the mechanisms of IBD mediated by innate immunity are incompletely understood and there are limited models of spontaneous innate immune colitis to address this question. Here we describe a new robust model of colitis occurring in the absence of adaptive immunity. RAG1-deficient mice expressing TNFAIP3 in intestinal epithelial cells (TRAG mice) spontaneously developed 100% penetrant, early-onset colitis that was limited to the colon and dependent on intestinal microbes but was not transmissible to co-housed littermates. TRAG colitis was associated with increased mucosal numbers of innate lymphoid cells (ILCs) and depletion of ILC prevented colitis in TRAG mice. ILC depletion also therapeutically reversed established colitis in TRAG mice. The colitis in TRAG mice was not prevented by interbreeding to mice lacking group 3 ILC nor by depletion of TNF. Treatment with the JAK inhibitor ruxolitinib ameliorated colitis in TRAG mice. This new model of colitis, with its predictable onset and colon-specific inflammation, will have direct utility in developing a more complete understanding of innate immune mechanisms that can contribute to colitis and in pre-clinical studies for effects of therapeutic agents on innate immune-mediated IBD." @default.
• W2817941793 created "2018-07-19" @default.
• W2817941793 creator A5011372389 @default.
• W2817941793 creator A5024697498 @default.
• W2817941793 creator A5027447458 @default.
• W2817941793 creator A5039494921 @default.
• W2817941793 creator A5066436537 @default.
• W2817941793 creator A5069117498 @default.
• W2817941793 creator A5083889469 @default.
• W2817941793 creator A5088183807 @default.
• W2817941793 creator A5089638626 @default.
• W2817941793 creator A5091421579 @default.
• W2817941793 creator A5045774787 @default.
• W2817941793 date "2018-07-09" @default.
• W2817941793 modified "2023-10-14" @default.
• W2817941793 title "The JAK inhibitor ruxolitinib reduces inflammation in an ILC3-independent model of innate immune colitis" @default.
• W2817941793 cites W1946093640 @default.
• W2817941793 cites W1957795404 @default.
• W2817941793 cites W1967949491 @default.
• W2817941793 cites W1968069981 @default.
• W2817941793 cites W1970063080 @default.
• W2817941793 cites W1984439354 @default.
• W2817941793 cites W1993339415 @default.
• W2817941793 cites W1993936200 @default.
• W2817941793 cites W1995747121 @default.
• W2817941793 cites W1996759553 @default.
• W2817941793 cites W2020781390 @default.
• W2817941793 cites W2024183493 @default.
• W2817941793 cites W2028057905 @default.
• W2817941793 cites W2041607290 @default.
• W2817941793 cites W2043801813 @default.
• W2817941793 cites W2051465794 @default.
• W2817941793 cites W2062782211 @default.
• W2817941793 cites W2063265278 @default.
• W2817941793 cites W2063746066 @default.
• W2817941793 cites W2070413937 @default.
• W2817941793 cites W2074569899 @default.
• W2817941793 cites W2077926569 @default.
• W2817941793 cites W2095880232 @default.
• W2817941793 cites W2099376515 @default.
• W2817941793 cites W2100091884 @default.
• W2817941793 cites W2121219094 @default.
• W2817941793 cites W2124499950 @default.
• W2817941793 cites W2136221987 @default.
• W2817941793 cites W2143625465 @default.
• W2817941793 cites W2150026400 @default.
• W2817941793 cites W2155395286 @default.
• W2817941793 cites W2159365085 @default.
• W2817941793 cites W2159407688 @default.
• W2817941793 cites W2164317756 @default.
• W2817941793 cites W2165872127 @default.
• W2817941793 cites W2166761831 @default.
• W2817941793 cites W2167264906 @default.
• W2817941793 cites W2170169072 @default.
• W2817941793 cites W2191813810 @default.
• W2817941793 cites W2412144208 @default.
• W2817941793 cites W2517849800 @default.
• W2817941793 cites W2525880468 @default.
• W2817941793 cites W2580360924 @default.
• W2817941793 cites W2583464358 @default.
• W2817941793 doi "https://doi.org/10.1038/s41385-018-0051-2" @default.
• W2817941793 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6162142" @default.
• W2817941793 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29988117" @default.
• W2817941793 hasPublicationYear "2018" @default.
• W2817941793 type Work @default.
• W2817941793 sameAs 2817941793 @default.
• W2817941793 citedByCount "9" @default.
• W2817941793 countsByYear W28179417932020 @default.
• W2817941793 countsByYear W28179417932021 @default.
• W2817941793 countsByYear W28179417932022 @default.
• W2817941793 countsByYear W28179417932023 @default.
• W2817941793 crossrefType "journal-article" @default.
• W2817941793 hasAuthorship W2817941793A5011372389 @default.
• W2817941793 hasAuthorship W2817941793A5024697498 @default.
• W2817941793 hasAuthorship W2817941793A5027447458 @default.
• W2817941793 hasAuthorship W2817941793A5039494921 @default.
• W2817941793 hasAuthorship W2817941793A5045774787 @default.
• W2817941793 hasAuthorship W2817941793A5066436537 @default.
• W2817941793 hasAuthorship W2817941793A5069117498 @default.
• W2817941793 hasAuthorship W2817941793A5083889469 @default.
• W2817941793 hasAuthorship W2817941793A5088183807 @default.
• W2817941793 hasAuthorship W2817941793A5089638626 @default.
• W2817941793 hasAuthorship W2817941793A5091421579 @default.
• W2817941793 hasBestOaLocation W28179417931 @default.
• W2817941793 hasConcept C136449434 @default.
• W2817941793 hasConcept C142724271 @default.
• W2817941793 hasConcept C193419808 @default.
• W2817941793 hasConcept C203014093 @default.
• W2817941793 hasConcept C2775862500 @default.
• W2817941793 hasConcept C2776112149 @default.
• W2817941793 hasConcept C2776914184 @default.
• W2817941793 hasConcept C2778260677 @default.
• W2817941793 hasConcept C2779134260 @default.
• W2817941793 hasConcept C2779341262 @default.
• W2817941793 hasConcept C2780007613 @default.
• W2817941793 hasConcept C2780076729 @default.
• W2817941793 hasConcept C47742525 @default.
• W2817941793 hasConcept C71924100 @default.

• next