Matches in SemOpenAlex for { <https://semopenalex.org/work/W2820006500> ?p ?o ?g. }
- W2820006500 abstract "Abstract Slc39a 8 encodes ZIP8, a divalent cation/bicarbonate symporter expressed in pluripotent mouse embryonic stem cells, and therefore ubiquitous in adult tissues; ZIP8 influxes Zn 2+ , Mn 2+ and Fe 2+ . Slc39a8(neo/neo) knockdown mice exhibit 10–15% of wild-type ZIP8 mRNA and protein levels, and show pleiotropic phenotype of stunted growth, neonatal lethality, multi-organ dysmorphogenesis, and dysregulated hematopoiesis manifested as severe anemia. Herein we performed RNA-seq analysis of gestational day (GD)13.5 yolk sac and placenta, and GD16.5 liver, kidney, lung, heart and cerebellum, comparing Slc39a8(neo/neo) with Slc39a8 (+/+) wild-type. Meta-data analysis of differentially-expressed genes revealed 29 unique genes from all tissues — having enriched GO categories associated with hematopoiesis and hypoxia and KEGG categories of complement, response to infection, and coagulation cascade — consistent with dysregulated hematopoietic stem cell fate. Based on transcription factor (TF) profiles in the JASPAR database, and searching for TF-binding sites enriched by Pscan, we identified numerous genes encoding zinc-finger and other TFs associated with hematopoietic stem cell functions. We conclude that, in this mouse model, deficient ZIP8-mediated divalent cation transport affects zinc-finger ( e.g . GATA proteins) and other TFs interacting with GATA proteins ( e.g . TAL1), predominantly in yolk sac. These data strongly support the phenotype of dysmorphogenesis and anemia seen in Slc39a8(neo/neo) mice in utero." @default.
- W2820006500 created "2018-07-19" @default.
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- W2820006500 creator A5082110272 @default.
- W2820006500 date "2018-07-16" @default.
- W2820006500 modified "2023-10-14" @default.
- W2820006500 title "In utero gene expression in the Slc39a8(neo/neo) knockdown mouse" @default.
- W2820006500 cites W1509086826 @default.
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- W2820006500 cites W1970164553 @default.
- W2820006500 cites W1970762630 @default.
- W2820006500 cites W1976844911 @default.
- W2820006500 cites W1978298108 @default.
- W2820006500 cites W2002924950 @default.
- W2820006500 cites W2003394120 @default.
- W2820006500 cites W2012095058 @default.
- W2820006500 cites W2014065793 @default.
- W2820006500 cites W2018172131 @default.
- W2820006500 cites W2020975063 @default.
- W2820006500 cites W2022939126 @default.
- W2820006500 cites W2024422626 @default.
- W2820006500 cites W2026731344 @default.
- W2820006500 cites W2032656951 @default.
- W2820006500 cites W2061125466 @default.
- W2820006500 cites W2067924463 @default.
- W2820006500 cites W2071637967 @default.
- W2820006500 cites W2071809778 @default.
- W2820006500 cites W2074299988 @default.
- W2820006500 cites W2092345183 @default.
- W2820006500 cites W2098134455 @default.
- W2820006500 cites W2100913647 @default.
- W2820006500 cites W2101357408 @default.
- W2820006500 cites W2101605059 @default.
- W2820006500 cites W2105991972 @default.
- W2820006500 cites W2110687686 @default.
- W2820006500 cites W2112390338 @default.
- W2820006500 cites W2113771680 @default.
- W2820006500 cites W2115801316 @default.
- W2820006500 cites W2118936153 @default.
- W2820006500 cites W2121077484 @default.
- W2820006500 cites W2123579381 @default.
- W2820006500 cites W2124032632 @default.
- W2820006500 cites W2126779745 @default.
- W2820006500 cites W2127184995 @default.
- W2820006500 cites W2130522035 @default.
- W2820006500 cites W2131247679 @default.
- W2820006500 cites W2132471916 @default.
- W2820006500 cites W2147311167 @default.
- W2820006500 cites W2152239989 @default.
- W2820006500 cites W2153118028 @default.
- W2820006500 cites W2154479259 @default.
- W2820006500 cites W2156189038 @default.
- W2820006500 cites W2157388004 @default.
- W2820006500 cites W2161175302 @default.
- W2820006500 cites W2166534929 @default.
- W2820006500 cites W2169966884 @default.
- W2820006500 cites W2177675473 @default.
- W2820006500 cites W2181502677 @default.
- W2820006500 cites W2187897300 @default.
- W2820006500 cites W2233236546 @default.
- W2820006500 cites W2287701530 @default.
- W2820006500 cites W2346865476 @default.
- W2820006500 cites W2388818629 @default.
- W2820006500 cites W2406250479 @default.
- W2820006500 cites W2504926893 @default.
- W2820006500 cites W2518901523 @default.
- W2820006500 cites W2519445944 @default.
- W2820006500 cites W2566437338 @default.
- W2820006500 cites W2567903706 @default.
- W2820006500 cites W2567935362 @default.
- W2820006500 cites W2580449060 @default.
- W2820006500 cites W2607654340 @default.
- W2820006500 cites W2610163363 @default.
- W2820006500 cites W2619062389 @default.
- W2820006500 cites W2622998555 @default.
- W2820006500 cites W2663413172 @default.
- W2820006500 cites W2740482955 @default.
- W2820006500 cites W2748708429 @default.
- W2820006500 cites W2750592126 @default.
- W2820006500 cites W2755943701 @default.
- W2820006500 cites W2756100287 @default.
- W2820006500 cites W2757192793 @default.
- W2820006500 cites W2763109317 @default.
- W2820006500 cites W2767933358 @default.
- W2820006500 cites W2783685107 @default.
- W2820006500 cites W387085543 @default.
- W2820006500 cites W756649930 @default.
- W2820006500 doi "https://doi.org/10.1038/s41598-018-29109-y" @default.
- W2820006500 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6048144" @default.
- W2820006500 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30013175" @default.
- W2820006500 hasPublicationYear "2018" @default.
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