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- W2820771851 abstract "Autologous tissue, like skin grafts and flaps, remain the gold standard for wound coverage. However, when autologous tissue isn’t practical, whether because of wound size, location, patient’s medical status or other factors, then bioengineering skin can provide an alternative to wound coverage while also minimizing patient risk. This tissue engineering skin substituent is designed with tree layers with different porosity of collagen - alginate scaffolds that try to mimic the extracellular matrix of the skin. Due to the special template, these multilayer scaffolds allowed both fibroblasts and keratinocytes to growth and proliferate to form similar support with skin extracellular matrix. The deep layer is the most porous and is a hypoderm template. After a period of tissue ingrown, this layer is seeded with autologous fat cells. The middle layer had a medium porosity, is the dermal template and it will be seeded with fibroblasts. The superficial layer is designed to receive the keratinocytes. Preliminary result showed excellent biomechanical and biocompatibility properties and good integration with cultured fibroblast and keratinocytes." @default.
- W2820771851 created "2018-07-19" @default.
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- W2820771851 date "2018-06-01" @default.
- W2820771851 modified "2023-10-18" @default.
- W2820771851 title "Abstract 10.45 ZETTASKIN – THE FIRST TRILAMINAR TISSUE ENGINEERING SKIN TEMPLATE – PRELIMINARY BIOMECHANICAL, BIOCOMPATIBILITY AND FIBROBLASTS AND KERATINOCYTES CULTURE CELLS SURVIVAL TESTING" @default.
- W2820771851 doi "https://doi.org/10.1097/01.gox.0000544071.17868.24" @default.
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