Matches in SemOpenAlex for { <https://semopenalex.org/work/W2821910033> ?p ?o ?g. }
- W2821910033 endingPage "e0200222" @default.
- W2821910033 startingPage "e0200222" @default.
- W2821910033 abstract "White spot syndrome virus (WSSV) is one of the most devastating pathogens of cultured shrimp, responsible for massive loss of its commercial products worldwide. The oriental river prawn Macrobrachium nipponense is an economically important species that is widely farmed in China and adult prawns can be infected by WSSV. However, the molecular mechanisms of the host pathogen interaction remain unknown. There is an urgent need to learn the host pathogen interaction between M. nipponense and WSSV which will be able to offer a solution in controlling the spread of WSSV. Next Generation Sequencing (NGS) was used in this study to determin the transcriptome differences by the comparison of control and WSSV-challenged moribund samples, control and WSSV-challenged survived samples of hepatopancreas in M. nipponense. A total of 64,049 predicted unigenes were obtained and classified into 63 functional groups. Approximately, 4,311 differential expression genes were identified with 3,308 genes were up-regulated when comparing the survived samples with the control. In the comparison of moribund samples with control, 1,960 differential expression genes were identified with 764 genes were up-regulated. In the contrast of two comparison libraries, 300 mutual DEGs with 95 up-regulated genes and 205 down-regulated genes. All the DEGs were performed GO and KEGG analysis, overall a total of 85 immune-related genes were obtained and these gene were groups into 13 functions and 4 KEGG pathways, such as protease inhibitors, heat shock proteins, oxidative stress, pathogen recognition immune receptors, PI3K/AKT/mTOR pathway, MAPK signaling pathway and Ubiquitin Proteasome Pathway. Ten genes that valuable in immune responses against WSSV were selected from those DEGs to furture discuss the response of host to WSSV. Results from this study contribute to a better understanding of the immune response of M. nipponense to WSSV, provide information for identifying novel genes in the absence of genome of M. nipponense. Furthermore, large number of transcripts obtained from this study could provide a strong basis for future genomic research on M. nipponense." @default.
- W2821910033 created "2018-07-19" @default.
- W2821910033 creator A5001838892 @default.
- W2821910033 creator A5007562617 @default.
- W2821910033 creator A5026817460 @default.
- W2821910033 creator A5028752147 @default.
- W2821910033 creator A5038462951 @default.
- W2821910033 creator A5052956914 @default.
- W2821910033 creator A5074920899 @default.
- W2821910033 creator A5080146887 @default.
- W2821910033 creator A5083249621 @default.
- W2821910033 date "2018-07-06" @default.
- W2821910033 modified "2023-10-06" @default.
- W2821910033 title "A transcriptome study on Macrobrachium nipponense hepatopancreas experimentally challenged with white spot syndrome virus (WSSV)" @default.
- W2821910033 cites W153625360 @default.
- W2821910033 cites W1543587531 @default.
- W2821910033 cites W1859006844 @default.
- W2821910033 cites W1898106370 @default.
- W2821910033 cites W1965563740 @default.
- W2821910033 cites W1967912613 @default.
- W2821910033 cites W1970511872 @default.
- W2821910033 cites W1971373148 @default.
- W2821910033 cites W1971899779 @default.
- W2821910033 cites W1973088761 @default.
- W2821910033 cites W1974882189 @default.
- W2821910033 cites W1976084389 @default.
- W2821910033 cites W1976360089 @default.
- W2821910033 cites W1978090289 @default.
- W2821910033 cites W1980042844 @default.
- W2821910033 cites W1985235100 @default.
- W2821910033 cites W1986627472 @default.
- W2821910033 cites W1986883956 @default.
- W2821910033 cites W1994694824 @default.
- W2821910033 cites W1995744610 @default.
- W2821910033 cites W2000267046 @default.
- W2821910033 cites W2001741734 @default.
- W2821910033 cites W2003400262 @default.
- W2821910033 cites W2004982147 @default.
- W2821910033 cites W2006964757 @default.
- W2821910033 cites W2011657487 @default.
- W2821910033 cites W2014553503 @default.
- W2821910033 cites W2020430828 @default.
- W2821910033 cites W2020942835 @default.
- W2821910033 cites W2022603493 @default.
- W2821910033 cites W2023001554 @default.
- W2821910033 cites W2028808368 @default.
- W2821910033 cites W2030683229 @default.
- W2821910033 cites W2033617388 @default.
- W2821910033 cites W2036252795 @default.
- W2821910033 cites W2039688795 @default.
- W2821910033 cites W2040433204 @default.
- W2821910033 cites W2041069637 @default.
- W2821910033 cites W2044685697 @default.
- W2821910033 cites W2044688063 @default.
- W2821910033 cites W2047979989 @default.
- W2821910033 cites W2056389022 @default.
- W2821910033 cites W2058349154 @default.
- W2821910033 cites W2059370380 @default.
- W2821910033 cites W2063601424 @default.
- W2821910033 cites W2064619356 @default.
- W2821910033 cites W2065254073 @default.
- W2821910033 cites W2066139634 @default.
- W2821910033 cites W2069137433 @default.
- W2821910033 cites W2083625471 @default.
- W2821910033 cites W2085898315 @default.
- W2821910033 cites W2087862854 @default.
- W2821910033 cites W2093139463 @default.
- W2821910033 cites W2094003420 @default.
- W2821910033 cites W2100303227 @default.
- W2821910033 cites W2102125479 @default.
- W2821910033 cites W2102863305 @default.
- W2821910033 cites W2103017472 @default.
- W2821910033 cites W2103740211 @default.
- W2821910033 cites W2103749584 @default.
- W2821910033 cites W2105106534 @default.
- W2821910033 cites W2105247092 @default.
- W2821910033 cites W2105381419 @default.
- W2821910033 cites W2107495112 @default.
- W2821910033 cites W2112050326 @default.
- W2821910033 cites W2113070427 @default.
- W2821910033 cites W2116166762 @default.
- W2821910033 cites W2122057254 @default.
- W2821910033 cites W2126419817 @default.
- W2821910033 cites W2126556352 @default.
- W2821910033 cites W2136804550 @default.
- W2821910033 cites W2139900059 @default.
- W2821910033 cites W2148853951 @default.
- W2821910033 cites W2156362263 @default.
- W2821910033 cites W2156534751 @default.
- W2821910033 cites W2159317375 @default.
- W2821910033 cites W2159482845 @default.
- W2821910033 cites W2160682354 @default.
- W2821910033 cites W2164154943 @default.
- W2821910033 cites W2164527179 @default.
- W2821910033 cites W2167490100 @default.
- W2821910033 cites W2174108472 @default.
- W2821910033 cites W2185675873 @default.
- W2821910033 cites W2190960788 @default.