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• W2822162620 abstract "Purpose To compare the in vitro antiparasitic effects of MGO™ Manuka honey and tea tree oil against ocular Demodex. Methods Fifty-two viable Demodex mites were acquired from the epilated eyelashes of 9 participants with blepharitis and symptomatic dry eye. Viable mites were randomised to one of five treatment groups: cyclodextrin-complexed and uncomplexed Manuka Honey, 100% and 50% tea tree oil, and no treatment. Following treatment application, mite viability was assessed for 240 min, based on limb and body movement and/or the development of a crenated/translucent appearance. Kaplan-Meier survival analysis was then performed. Results The log-rank test demonstrated a significant treatment effect on the survival distribution of Demodex mites (p < 0.001). Bonferroni-corrected post-hoc pairwise analysis showed that all treatments except for uncomplexed honey effected lower survival probabilities than the untreated group (all p < 0.001). Among the four treatments, survival probabilities were lowest with 100% tea tree oil (all p < 0.001), and highest with uncomplexed honey (all p ≤ 0.001). No difference was observed between complexed honey and 50% tea tree oil (p = 0.81). Conclusions The in vitro efficacy of cyclodextrin-complexed Manuka honey was comparable with 50% tea tree oil, an established treatment for ocular Demodex. The findings support future clinical trials investigating the therapeutic effects of complexed honey in demodectic blepharitis patients." @default.
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• W2822162620 date "2018-12-01" @default.
• W2822162620 modified "2023-09-27" @default.
• W2822162620 title "Comparing the in vitro effects of MGO™ Manuka honey and tea tree oil on ocular Demodex viability" @default.
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• W2822162620 doi "https://doi.org/10.1016/j.clae.2018.06.006" @default.
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