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- W282227710 abstract "Attempts were made to determine whether pretreatment of irradiated, marrow-injected leukemic mice has a lifeprolonging effect. L 1210 leukemic cells, originally obtained from DBA/2 mice, were injected subcutaneously in F/sub 1/ hybrid mice (C57B16 x DBA/2). The mean survival time of the mice (11.0 days) was prolonged by treatment with the antimitotic agents amethopterin (21 days) and cyclophosphamide (15.5 days). Whole-body 850-rad x irradiation of the untreated leukemic mice slightly prolonged survival time (14.4 days), and this time was further prolonged by an injection of isologous (C57B16) bone marrow cells (22.6 days). Pretreatment of mice with the chemical agents, before irradiation and marrow replacement, significantly enhanced survival time. The effect was more pronounced with amethopterin (26.5 days) than cyclophosphamide (23.1 days). By combined use of marrow grafts and the antimiotic drugs it was possible to obtain prolonged survival (>70 days) of 9 out of 111 irradiated, leukemic mice. (H.H.D.)" @default.
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- W282227710 date "1962-01-01" @default.
- W282227710 modified "2023-09-24" @default.
- W282227710 title "BONE MARROW GRAFTS AFTER TOTAL-BODY IRRADIATION OF LEUKEMIC MICE FOLLOWING THE ADMINISTRATION OF AN ANTIMITOTIC AGENT" @default.
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