FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2822911302> ?p ?o ?g. }

• W2822911302 endingPage "e21480" @default.
• W2822911302 startingPage "e21480" @default.
• W2822911302 abstract "Aluminum (Al) is an important environmental metal factor that can be potentially associated with pathological changes leading to neurotoxicity. The silkworm, Bombyx mori, is an important economic insect and has also been used as a model organism in various research areas. However, the toxicity of Al on silkworm physiology has not been reported. Here, we comprehensively investigate the toxic effects of Al on the silkworm, focusing on its effects on viability and development, superoxide dismutase (SOD) activity, and the expression of presenilin and cAMP response element-binding protein (CREB) in BmE cells and silkworm larvae. BmE cell viability decreased after treatment with aluminum chloride (AlCl3 ) in both dose- and time-dependent manners. When AlCl3 solution was injected into newly hatched fifth instar larvae, both larval weight gain and survival rate were significantly decreased in a manner correlating with AlCl3 dose and developmental stage. Furthermore, when BmE cells and silkworm larvae were exposed to AlCl3 , SOD activity decreased significantly relative to the control group, whereas presenilin expression increased more than twofold. Additionally, CREB and phosphorylated CREB (p-CREB) expression in the heads of fifth instar larvae decreased by 28.0% and 50.0%, respectively. These results indicate that Al inhibits the growth and development of silkworms in vitro and in vivo, altering SOD activity and the expressions of presenilin, CREB, and p-CREB. Our data suggest that B. mori can serve as a model animal for studying Al-induced neurotoxicity or neurodegeneration." @default.
• W2822911302 created "2018-07-19" @default.
• W2822911302 creator A5000279052 @default.
• W2822911302 creator A5005003245 @default.
• W2822911302 creator A5006183393 @default.
• W2822911302 creator A5010130120 @default.
• W2822911302 creator A5015268232 @default.
• W2822911302 creator A5016485135 @default.
• W2822911302 creator A5024992807 @default.
• W2822911302 creator A5029597939 @default.
• W2822911302 creator A5076111842 @default.
• W2822911302 date "2018-07-05" @default.
• W2822911302 modified "2023-09-27" @default.
• W2822911302 title "Aluminum toxicity related to SOD and expression of presenilin and CREB in <i>Bombyx mori</i>" @default.
• W2822911302 cites W1177965257 @default.
• W2822911302 cites W1502037580 @default.
• W2822911302 cites W1595291832 @default.
• W2822911302 cites W1963506081 @default.
• W2822911302 cites W1964803638 @default.
• W2822911302 cites W1970164987 @default.
• W2822911302 cites W1974551785 @default.
• W2822911302 cites W1977549725 @default.
• W2822911302 cites W1983233983 @default.
• W2822911302 cites W1995205529 @default.
• W2822911302 cites W2000832574 @default.
• W2822911302 cites W2003679747 @default.
• W2822911302 cites W2004281069 @default.
• W2822911302 cites W2012130997 @default.
• W2822911302 cites W2030926835 @default.
• W2822911302 cites W2033326153 @default.
• W2822911302 cites W2042927392 @default.
• W2822911302 cites W2049134173 @default.
• W2822911302 cites W2051226585 @default.
• W2822911302 cites W2064025683 @default.
• W2822911302 cites W2064740558 @default.
• W2822911302 cites W2068412840 @default.
• W2822911302 cites W2072215964 @default.
• W2822911302 cites W2072367810 @default.
• W2822911302 cites W2076782084 @default.
• W2822911302 cites W2078604626 @default.
• W2822911302 cites W2083053526 @default.
• W2822911302 cites W2090387148 @default.
• W2822911302 cites W2093159853 @default.
• W2822911302 cites W2150264917 @default.
• W2822911302 cites W2152067700 @default.
• W2822911302 cites W2206133582 @default.
• W2822911302 cites W2338386904 @default.
• W2822911302 cites W2481709804 @default.
• W2822911302 cites W2605906420 @default.
• W2822911302 cites W2625281595 @default.
• W2822911302 cites W2754009845 @default.
• W2822911302 cites W294880027 @default.
• W2822911302 doi "https://doi.org/10.1002/arch.21480" @default.
• W2822911302 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29978503" @default.
• W2822911302 hasPublicationYear "2018" @default.
• W2822911302 type Work @default.
• W2822911302 sameAs 2822911302 @default.
• W2822911302 citedByCount "5" @default.
• W2822911302 countsByYear W28229113022020 @default.
• W2822911302 countsByYear W28229113022021 @default.
• W2822911302 countsByYear W28229113022023 @default.
• W2822911302 crossrefType "journal-article" @default.
• W2822911302 hasAuthorship W2822911302A5000279052 @default.
• W2822911302 hasAuthorship W2822911302A5005003245 @default.
• W2822911302 hasAuthorship W2822911302A5006183393 @default.
• W2822911302 hasAuthorship W2822911302A5010130120 @default.
• W2822911302 hasAuthorship W2822911302A5015268232 @default.
• W2822911302 hasAuthorship W2822911302A5016485135 @default.
• W2822911302 hasAuthorship W2822911302A5024992807 @default.
• W2822911302 hasAuthorship W2822911302A5029597939 @default.
• W2822911302 hasAuthorship W2822911302A5076111842 @default.
• W2822911302 hasConcept C104317684 @default.
• W2822911302 hasConcept C126322002 @default.
• W2822911302 hasConcept C1629964 @default.
• W2822911302 hasConcept C175344181 @default.
• W2822911302 hasConcept C181199279 @default.
• W2822911302 hasConcept C202751555 @default.
• W2822911302 hasConcept C2775838275 @default.
• W2822911302 hasConcept C2778487026 @default.
• W2822911302 hasConcept C2779134260 @default.
• W2822911302 hasConcept C2779491297 @default.
• W2822911302 hasConcept C29730261 @default.
• W2822911302 hasConcept C502032728 @default.
• W2822911302 hasConcept C53227056 @default.
• W2822911302 hasConcept C55493867 @default.
• W2822911302 hasConcept C71924100 @default.
• W2822911302 hasConcept C86339819 @default.
• W2822911302 hasConcept C86803240 @default.
• W2822911302 hasConceptScore W2822911302C104317684 @default.
• W2822911302 hasConceptScore W2822911302C126322002 @default.
• W2822911302 hasConceptScore W2822911302C1629964 @default.
• W2822911302 hasConceptScore W2822911302C175344181 @default.
• W2822911302 hasConceptScore W2822911302C181199279 @default.
• W2822911302 hasConceptScore W2822911302C202751555 @default.
• W2822911302 hasConceptScore W2822911302C2775838275 @default.
• W2822911302 hasConceptScore W2822911302C2778487026 @default.
• W2822911302 hasConceptScore W2822911302C2779134260 @default.
• W2822911302 hasConceptScore W2822911302C2779491297 @default.

• next