FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2823321225> ?p ?o ?g. }

• W2823321225 endingPage "121" @default.
• W2823321225 startingPage "105" @default.
• W2823321225 abstract "An endogenous molecular clockwork drives various cellular pathways including metabolism and the cell cycle. Its dysregulation is able to prompt pathological phenotypes including cancer. Besides dramatic metabolic alterations, cancer cells display severe changes in the clock phenotype with likely consequences in tumor progression and treatment response. In this study, we use a comprehensive systems-driven approach to investigate the effect of clock disruption on metabolic pathways and its impact on drug response in a cellular model of colon cancer progression. We identified distinctive time-related transcriptomic and metabolic features of a primary tumor and its metastatic counterpart. A mapping of the expression data to a comprehensive genome-scale reconstruction of human metabolism allowed for the in-depth functional characterization of 24 h-oscillating transcripts and pointed to a clock-driven metabolic reprogramming in tumorigenesis. In particular, we identified a set of five clock-regulated glycolysis genes, ALDH3A2, ALDOC, HKDC1, PCK2, and PDHB with differential temporal expression patterns. These findings were validated in organoids and in primary fibroblasts isolated from normal colon and colon adenocarcinoma from the same patient. We further identified a reciprocal connection of HKDC1 to the clock in the primary tumor, which is lost in the metastatic cells. Interestingly, a disruption of the core-clock gene BMAL1 impacts on HKDC1 and leads to a time-dependent rewiring of metabolism, namely an increase in glycolytic activity, as well as changes in treatment response. This work provides novel evidence regarding the complex interplay between the circadian clock and metabolic alterations in carcinogenesis and identifies new connections between both systems with pivotal roles in cancer progression and response to therapy." @default.
• W2823321225 created "2018-07-19" @default.
• W2823321225 creator A5001048533 @default.
• W2823321225 creator A5003631855 @default.
• W2823321225 creator A5008558621 @default.
• W2823321225 creator A5013039943 @default.
• W2823321225 creator A5030238472 @default.
• W2823321225 creator A5039786016 @default.
• W2823321225 creator A5041763620 @default.
• W2823321225 creator A5050212918 @default.
• W2823321225 creator A5056759756 @default.
• W2823321225 creator A5064338064 @default.
• W2823321225 creator A5079499882 @default.
• W2823321225 creator A5080374621 @default.
• W2823321225 creator A5083532124 @default.
• W2823321225 creator A5090256680 @default.
• W2823321225 creator A5090331009 @default.
• W2823321225 date "2018-07-01" @default.
• W2823321225 modified "2023-10-15" @default.
• W2823321225 title "The Circadian Clock Regulates Metabolic Phenotype Rewiring Via HKDC1 and Modulates Tumor Progression and Drug Response in Colorectal Cancer" @default.
• W2823321225 cites W1033849314 @default.
• W2823321225 cites W114098355 @default.
• W2823321225 cites W1645904319 @default.
• W2823321225 cites W1860605136 @default.
• W2823321225 cites W1865957711 @default.
• W2823321225 cites W1879352431 @default.
• W2823321225 cites W1975701262 @default.
• W2823321225 cites W1993983731 @default.
• W2823321225 cites W1996638203 @default.
• W2823321225 cites W1997364930 @default.
• W2823321225 cites W1998478329 @default.
• W2823321225 cites W2000697370 @default.
• W2823321225 cites W2003605385 @default.
• W2823321225 cites W2009682967 @default.
• W2823321225 cites W2013244539 @default.
• W2823321225 cites W2016397316 @default.
• W2823321225 cites W2025404088 @default.
• W2823321225 cites W2042957122 @default.
• W2823321225 cites W2050040190 @default.
• W2823321225 cites W2051705756 @default.
• W2823321225 cites W2053291546 @default.
• W2823321225 cites W2059920458 @default.
• W2823321225 cites W2067575395 @default.
• W2823321225 cites W2074175804 @default.
• W2823321225 cites W2076131979 @default.
• W2823321225 cites W2079839199 @default.
• W2823321225 cites W2082697543 @default.
• W2823321225 cites W2084074983 @default.
• W2823321225 cites W2088417711 @default.
• W2823321225 cites W2089519715 @default.
• W2823321225 cites W2093419981 @default.
• W2823321225 cites W2094294962 @default.
• W2823321225 cites W2104297374 @default.
• W2823321225 cites W2106318552 @default.
• W2823321225 cites W2107277218 @default.
• W2823321225 cites W2109972881 @default.
• W2823321225 cites W2120865735 @default.
• W2823321225 cites W2128643078 @default.
• W2823321225 cites W2140400704 @default.
• W2823321225 cites W2155667080 @default.
• W2823321225 cites W2156003764 @default.
• W2823321225 cites W2162928593 @default.
• W2823321225 cites W2164498509 @default.
• W2823321225 cites W2192080449 @default.
• W2823321225 cites W2207298791 @default.
• W2823321225 cites W2214783674 @default.
• W2823321225 cites W2234115940 @default.
• W2823321225 cites W2271458278 @default.
• W2823321225 cites W2271948826 @default.
• W2823321225 cites W2328246325 @default.
• W2823321225 cites W2333798941 @default.
• W2823321225 cites W2340356302 @default.
• W2823321225 cites W2346611535 @default.
• W2823321225 cites W2395626624 @default.
• W2823321225 cites W2418056440 @default.
• W2823321225 cites W2519942994 @default.
• W2823321225 cites W2557012776 @default.
• W2823321225 cites W2561271722 @default.
• W2823321225 cites W2586265133 @default.
• W2823321225 cites W2588955044 @default.
• W2823321225 cites W2605280287 @default.
• W2823321225 cites W2771947879 @default.
• W2823321225 cites W2796205256 @default.
• W2823321225 cites W4211057115 @default.
• W2823321225 doi "https://doi.org/10.1016/j.ebiom.2018.07.002" @default.
• W2823321225 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6085544" @default.
• W2823321225 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30005951" @default.
• W2823321225 hasPublicationYear "2018" @default.
• W2823321225 type Work @default.
• W2823321225 sameAs 2823321225 @default.
• W2823321225 citedByCount "70" @default.
• W2823321225 countsByYear W28233212252018 @default.
• W2823321225 countsByYear W28233212252019 @default.
• W2823321225 countsByYear W28233212252020 @default.
• W2823321225 countsByYear W28233212252021 @default.
• W2823321225 countsByYear W28233212252022 @default.
• W2823321225 countsByYear W28233212252023 @default.
• W2823321225 crossrefType "journal-article" @default.

• next