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- W2823573144 abstract "Two efflux transporters, ATP-binding cassettes B1 (ABCB1) and G2 (ABCG2), are highly expressed in the endothelial cells of the brain, where they regulate the bioavailability and distribution of several endogenous and xenobiotic compounds. However, whether ABCB1 or ABCG2 has any link with drug dependence, drug withdrawal effects, or the incidence of adverse effects in drug abuser is not known. In this study, we determined the effects of voluntary ethanol consumption following repeated exposure to cocaine or vehicle on the relative mRNA and protein expression of Abcg2/ABCG2 and Abcb1/ABCB1 in the nucleus accumbens (NAc) and medial prefrontal cortex (mPFC) of male alcohol-preferring (P) rats. Male P rats were allowed free choice access to ethanol (15 and 30% v/v) and water for 5 weeks to establish baseline drinking behavior. The following week, rats were either injected with 20 mg/kg i.p. of cocaine or saline, once a day, for 7 days. The relative mRNA and protein expression of Abcb1/ABCB1 and Abcg2/ABCG2 in the NAc and mPFC were significantly decreased in ethanol-saline- and ethanol-cocaine-exposed rats compared to control rats that received neither ethanol nor cocaine. Thus, prolonged exposure to commonly abused drugs, ethanol and cocaine, alters the expression of Abcb1/ABCB1 and Abcg2/ABCG2 mRNA and protein levels in brain areas that play a role in drug dependence." @default.
- W2823573144 created "2018-07-19" @default.
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- W2823573144 date "2018-07-06" @default.
- W2823573144 modified "2023-09-30" @default.
- W2823573144 title "Alcohol and Cocaine Exposure Modulates ABCB1 and ABCG2 Transporters in Male Alcohol-Preferring Rats" @default.
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- W2823573144 cites W1547613518 @default.
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- W2823573144 cites W1847911293 @default.
- W2823573144 cites W1848006821 @default.
- W2823573144 cites W1965113982 @default.
- W2823573144 cites W1969317435 @default.
- W2823573144 cites W1975931952 @default.
- W2823573144 cites W1980170993 @default.
- W2823573144 cites W1981444301 @default.
- W2823573144 cites W1982476232 @default.
- W2823573144 cites W1992593963 @default.
- W2823573144 cites W1999190513 @default.
- W2823573144 cites W1999231401 @default.
- W2823573144 cites W2001981401 @default.
- W2823573144 cites W2005763225 @default.
- W2823573144 cites W2006434892 @default.
- W2823573144 cites W2009962309 @default.
- W2823573144 cites W2013276274 @default.
- W2823573144 cites W2013817083 @default.
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- W2823573144 cites W2016149358 @default.
- W2823573144 cites W2017227893 @default.
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- W2823573144 cites W2021275669 @default.
- W2823573144 cites W2023476241 @default.
- W2823573144 cites W2024713289 @default.
- W2823573144 cites W2029177281 @default.
- W2823573144 cites W2032811036 @default.
- W2823573144 cites W2032866878 @default.
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- W2823573144 cites W2072485370 @default.
- W2823573144 cites W2077055967 @default.
- W2823573144 cites W2083105679 @default.
- W2823573144 cites W2085706486 @default.
- W2823573144 cites W2088453708 @default.
- W2823573144 cites W2090590608 @default.
- W2823573144 cites W2091280739 @default.
- W2823573144 cites W2096313349 @default.
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- W2823573144 cites W2144190487 @default.
- W2823573144 cites W2144471602 @default.
- W2823573144 cites W2146109103 @default.
- W2823573144 cites W2148042336 @default.
- W2823573144 cites W2149385083 @default.
- W2823573144 cites W2151191128 @default.
- W2823573144 cites W2306722669 @default.
- W2823573144 cites W2408061839 @default.
- W2823573144 cites W2602538801 @default.
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- W2823573144 doi "https://doi.org/10.1007/s12035-018-1153-2" @default.
- W2823573144 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7780301" @default.
- W2823573144 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29978425" @default.
- W2823573144 hasPublicationYear "2018" @default.
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