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- W282360012 abstract "G A A b st ra ct s inhibited Ca2+ dependent exocytosis by 40%. In contrast, synaptotagmin 3 immunoreactivity was localized to acinar light microsomal fractions and furthermore immunolocalized to vesicular structures positive for lysosomal membrane protein 1 present in acinar cytoplasm. Finally, a soluble construct of synaptotagmin 3 had no effects on CA2+ stimulated secretion from permeabilized acini. Collectively, these data indicate that acinar cells express synaptotagmin 1 in a small population of zymogen granules and along the apical plasma membrane and suggests that it plays a functional role in acinar secretion whereas synaptotagmin 3 likely has an alternative role in lysosomal membrane trafficking." @default.
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- W282360012 date "2011-05-01" @default.
- W282360012 modified "2023-10-18" @default.
- W282360012 title "Specific Deletion of Insulin Receptors on Pancreatic Acinar Cells Defines the Insulin-Acinar Axis: Implications for Pancreatic Insufficiency in Diabetes" @default.
- W282360012 doi "https://doi.org/10.1016/s0016-5085(11)60631-8" @default.
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