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- W282360918 abstract "Prosaposin is a multifunctional locus in man and mice which encodes a tandem and in the same reading frame four glycoprotein activators or saposins of lysosomal hydrolases. These ubiquitously expressed glycoproteins and the precursor, prosaposin, have been proposed to function in glycosphingolipid catabolic pathways and glycolipid transport. Like other lysosomal genes, it was thought to be regulated at a low level, a `housekeeping gene`; this was not the case. To characterize the temporal and spatial expression of the prosaposin loci, prenatal and postnatal mouse tissues were screened with the murine antisense riboprobe by in situ hybridization. Prenatally, prosaposin mRNA was expressed differentially in decidual layers of the placenta, particularly, the decidua capsularis. The dorsal root ganglia also showed higher levels expression than surrounding tissues. In comparison, high level differential expression of prosaposin was clearly evident postnatally in a variety of organs. In secretory epithelial cells of the choroid plexus, ventricular lining, upper trachea, esophagus, cortical renal tubules of the kidney, epididymis and sertoli cells of the testes. Discrete localization of prosaposin mRNA expression was also found in neurons of the cerebral cortex, cerebellar cortex and lateral columns of the spinal cord as well as in hepatocytes of the mature liver.more » Very high levels of expression were found in lipid-secreting cells of the Harderian glands and corpus luteum of the ovary, macrophages of intestinal lymph nodes, splenic tissue and thymus. Studies in selected human tissues indicate a similar pattern of expression. These studies show specific spatial and temporal prosaposin expression in a heretofore thought of lysosomal `housekeeping` locus that suggests a pivitol role for this locus in the tissue expression of glycosphingolipid storage diseases.« less" @default.
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- W282360918 date "1994-09-01" @default.
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- W282360918 title "Unexpected regulation of a `housekeeping gene:` Spatial and temporal expression of a multifunctional lysosomal gene, prosaposin" @default.
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