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- W2823828888 abstract "The aggressive B-cell lymphomas are a diverse collection of cancers grouped together based on clinical behavior and derivation from B lymphocytes. Genomic analyses on these tumours are now translating into improved classification systems and identification of underpinning targetable biology. Simple karyotyping revealed key translocations involving MYC, BCL2, and BCL6 that have impacted lymphoma classification in the World Health Organization classification scheme. Subsequently, gene expression profiling identified molecular subgroups within the most common lymphoma, diffuse large B-cell lymphoma (DLBCL): activated B-cell-like and germinal centre B-cell-like. Finally, next generation sequencing has revealed a modest number of frequently mutated genes and a long list of infrequent mutations. The mutational landscapes involve diverse genes associated with dysregulated signalling, epigenetic modification, blockade of cellular differentiation, and immune evasion. These mutational signatures are enriched in the different aggressive lymphoma subtypes impacting phenotypes and identifying therapeutic targets. Challenges to implementing genomic assays into clinical practice remain." @default.
- W2823828888 created "2018-07-19" @default.
- W2823828888 creator A5014743270 @default.
- W2823828888 creator A5021133318 @default.
- W2823828888 date "2018-09-01" @default.
- W2823828888 modified "2023-09-23" @default.
- W2823828888 title "Dissecting aggressive B-cell lymphoma through genomic analysis – What is clinically relevant?" @default.
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