Matches in SemOpenAlex for { <https://semopenalex.org/work/W2823909538> ?p ?o ?g. }
- W2823909538 endingPage "2018" @default.
- W2823909538 startingPage "2003" @default.
- W2823909538 abstract "Gram‐negative pathogens represent a significant global health threat, while the emergency and widespread of drug resistance make the situation even worse. As “privileged building blocks,” 4‐quinolones including fluoroquinolones are mainstays of chemotherapy against various bacterial infections. However, as other antibiotics, the resistance of Gram‐negative bacteria to 4‐quinolones develops rapidly and spreads widely throughout the world. To overcome the resistance and improve the potency, a number of 4‐quinolone derivatives were designed, synthesized, and screened for their in vitro and in vivo activities against representative Gram‐negative pathogens. This review aims to summarize the recent advances made towards the discovery of 4‐quinolone derivatives as anti‐Gram‐negative agents as well as their structure–activity relationship. The enriched structure–activity relationship paves the way to the further rational development of 4‐quinolones with excellent potency against both drug‐susceptible and drug‐resistant Gram‐negative pathogens." @default.
- W2823909538 created "2018-07-19" @default.
- W2823909538 creator A5071963696 @default.
- W2823909538 date "2018-07-05" @default.
- W2823909538 modified "2023-09-27" @default.
- W2823909538 title "4-Quinolone Derivatives and Their Activities Against Gram-negative Pathogens" @default.
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