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• W28264501 abstract "Dendritic cells(DC) are professional antigen presenting cells bridging the innate and adaptive immune systems by detecting pathogen- and- damage associated molecular pattern(PAMP, DAMP) molecules. This triggers maturation and migration to regional lymph nodes where they stimulate T lymphocytes. In tissues normally exposed to relatively high level of PAMP molecules, such as the liver, DC have a higher threshold to stimulation and therefore maintain an immature phenotype under conditions that would stimulate DC at other sites. In these studies we tested the hypothesis that interleukin-6(IL-6)/Signal Transducer and Activation of Transcription-3(STAT3) activity increases the activation/maturation threshold of hepatic and bone marrow(BM) DC towards innate immune signals. Results show that liver nuclear STAT3 activity is significantly higher than other organs and is IL-6-dependent. Hepatic DC in normal wild-type(IL-6+/+) mice are phenotypically and functionally less mature than DC from IL-6-deficient(IL-6-/-) or STAT3 inhibited IL-6+/+ mice, as determined by surface marker expression, pro-inflammatory cytokine secretion, and allogenic T-cell stimulation. IL-6+/+ liver DC produce IL-6 in response to exposure to PAMPs, but resist maturation compared to IL-6-/- liver DC. Conversely, exogenous IL-6 inhibits LPS-induced IL-6-/- liver DC maturation. Oral antibiotic depletion of commensal gut bacteria in IL-6+/+ mice decreased portal blood endotoxin levels, lowered IL-6/STAT3 activity and significantly increased liver DC maturation. BM derived IL-6+/+DC with elevated STAT3 activity are also significantly less mature than IL-6-/- BMDC. The reduced maturation was especially pronounced when IL-6+/+ BMDC when cultured in elevated IL-6 conditions. IL-6 neutralization increased BMDC maturation. Blocking STAT3 activity increases maturation in IL-6+/+ BMDC but not in IL-6-/- BMDC, which have low basal STAT3 activity. Compared to IL-6-/- BMDC, IL-6+/+ BMDC significantly resisted maturation in response to low concentrations of the PAMP molecules. At higher concentrations of these same ligands stimulation of both IL-6+/+ and IL-6-/- BMDC induced maturation.In Conclusion, gut-derived bacterial products, by stimulating hepatic IL-6/STAT3 signaling, inhibit hepatic DC activation/maturation. Elevated IL-6/STAT3 activity raises the threshold needed for DC to translate triggers of innate immunity into adaptive immune responses. Manipulating gut bacteria or IL-6/STAT3 activity may therefore be an effective strategy to alter intra-hepatic immune responses." @default.
• W28264501 created "2016-06-24" @default.
• W28264501 creator A5030014458 @default.
• W28264501 creator A5084674630 @default.
• W28264501 date "2007-12-07" @default.
• W28264501 modified "2023-09-27" @default.
• W28264501 title "Inhibition of liver and bone marrow derived dendritic cell maturation and function by Interleukin-6 activation of Signal Transducer and Activator of Transcription-3" @default.
• W28264501 cites W109291748 @default.
• W28264501 cites W11321320 @default.
• W28264501 cites W14741340 @default.
• W28264501 cites W1491342045 @default.
• W28264501 cites W1496109170 @default.
• W28264501 cites W1497797754 @default.
• W28264501 cites W1498929362 @default.
• W28264501 cites W1499740591 @default.
• W28264501 cites W1503899313 @default.
• W28264501 cites W1514412416 @default.
• W28264501 cites W1515725948 @default.
• W28264501 cites W1516719898 @default.
• W28264501 cites W1539584528 @default.
• W28264501 cites W1541585193 @default.
• W28264501 cites W1562592996 @default.
• W28264501 cites W157721590 @default.
• W28264501 cites W1577284202 @default.
• W28264501 cites W1578157386 @default.
• W28264501 cites W1583209620 @default.
• W28264501 cites W1585321597 @default.
• W28264501 cites W159439519 @default.
• W28264501 cites W1594523905 @default.
• W28264501 cites W1600231838 @default.
• W28264501 cites W1633418194 @default.
• W28264501 cites W163630733 @default.
• W28264501 cites W1661544713 @default.
• W28264501 cites W1668039320 @default.
• W28264501 cites W167148815 @default.
• W28264501 cites W167571371 @default.
• W28264501 cites W1743711678 @default.
• W28264501 cites W1761831931 @default.
• W28264501 cites W1825344511 @default.
• W28264501 cites W1838497045 @default.
• W28264501 cites W1851677105 @default.
• W28264501 cites W1857552597 @default.
• W28264501 cites W1892344960 @default.
• W28264501 cites W1898195399 @default.
• W28264501 cites W1906591077 @default.
• W28264501 cites W1928772928 @default.
• W28264501 cites W1939561089 @default.
• W28264501 cites W1945216762 @default.
• W28264501 cites W1960538598 @default.
• W28264501 cites W1960585934 @default.
• W28264501 cites W1965847911 @default.
• W28264501 cites W1966259152 @default.
• W28264501 cites W1968141301 @default.
• W28264501 cites W1968587886 @default.
• W28264501 cites W1969893909 @default.
• W28264501 cites W1971309107 @default.
• W28264501 cites W1972264376 @default.
• W28264501 cites W1972346208 @default.
• W28264501 cites W1972809211 @default.
• W28264501 cites W1972932855 @default.
• W28264501 cites W1973890327 @default.
• W28264501 cites W1975463463 @default.
• W28264501 cites W1975762173 @default.
• W28264501 cites W1975773833 @default.
• W28264501 cites W1976320059 @default.
• W28264501 cites W1977812921 @default.
• W28264501 cites W1978530585 @default.
• W28264501 cites W1980123888 @default.
• W28264501 cites W1980138671 @default.
• W28264501 cites W1980794669 @default.
• W28264501 cites W1981817625 @default.
• W28264501 cites W1981969796 @default.
• W28264501 cites W1982875532 @default.
• W28264501 cites W1983357853 @default.
• W28264501 cites W1983985556 @default.
• W28264501 cites W1984748165 @default.
• W28264501 cites W1987110376 @default.
• W28264501 cites W1987116953 @default.
• W28264501 cites W1987150557 @default.
• W28264501 cites W1988662791 @default.
• W28264501 cites W1989944445 @default.
• W28264501 cites W1990069486 @default.
• W28264501 cites W1990236675 @default.
• W28264501 cites W1991130140 @default.
• W28264501 cites W1992439632 @default.
• W28264501 cites W1993520606 @default.
• W28264501 cites W1993544422 @default.
• W28264501 cites W1994016440 @default.
• W28264501 cites W1994262539 @default.
• W28264501 cites W1995744610 @default.
• W28264501 cites W1995997868 @default.
• W28264501 cites W1997047331 @default.
• W28264501 cites W1997708871 @default.
• W28264501 cites W1998435868 @default.
• W28264501 cites W1998525935 @default.
• W28264501 cites W1998755899 @default.
• W28264501 cites W1998769740 @default.
• W28264501 cites W1999023229 @default.
• W28264501 cites W2000768335 @default.
• W28264501 cites W2001281185 @default.

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