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- W2829142499 endingPage "1167" @default.
- W2829142499 startingPage "1167" @default.
- W2829142499 abstract "In recent decades, nanotechnology has made phenomenal strides in the pharmaceutical field, favouring the improvement of the biopharmaceutical properties of many active compounds. Many liposome-based formulations containing antitumor, antioxidant and antifungal compounds are presently on the market and are used daily (for example Doxil®/Caelyx® and Ambisome®). Polymeric nanoparticles have also been used to entrap many active compounds with the aim of improving their pharmacological activity, bioavailability and plasmatic half-life while decreasing their side effects. The modulation of the structural/morphological properties of nanoparticles allows us to influence various technological parameters, such as the loading capacity and/or the release profile of the encapsulated drug(s). Amongst the biocompatible polymers, poly(D,L-lactide) (PLA), poly(D,L-glycolide) (PLG) and their co-polymers poly(lactide-co-glycolide) (PLGA) are the most frequently employed due to their approval by the FDA for human use. The aim of this review is to provide a description of the foremost recent investigations based on the encapsulation of amphotericin B in PLGA nanoparticles, in order to furnish an overview of the technological properties of novel colloidal formulations useful in the treatment of Leishmaniasis. The pharmacological efficacy of the drug after nanoencapsulation will be compared to the commercial formulations of the drug (i.e., Fungizone®, Ambisome®, Amphocil® and Abelcet®)." @default.
- W2829142499 created "2018-07-19" @default.
- W2829142499 creator A5021109233 @default.
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- W2829142499 creator A5084411179 @default.
- W2829142499 creator A5088201710 @default.
- W2829142499 creator A5089413354 @default.
- W2829142499 date "2018-07-09" @default.
- W2829142499 modified "2023-09-23" @default.
- W2829142499 title "Antileishmanial Activity of Amphotericin B-loaded-PLGA Nanoparticles: An Overview" @default.
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- W2829142499 doi "https://doi.org/10.3390/ma11071167" @default.
- W2829142499 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6073796" @default.
- W2829142499 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29987206" @default.
- W2829142499 hasPublicationYear "2018" @default.
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