FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2829413044> ?p ?o ?g. }

• W2829413044 endingPage "280" @default.
• W2829413044 startingPage "251" @default.
• W2829413044 abstract "Background: The clinical and preclinical exploration of the therapeutic properties of vitamin D have significantly increased in the past decade, owing to the growing associative evidence suggesting vitamin D is neuroprotective. However, whether depletion of vitamin D contributes to the onset of neurological disorders or is a symptom of neurological disease has yet to be defined. Much remains unclear about the causal role of vitamin D and the method of use and forms of vitamin D.Objectives: We sought to quantitatively assess if neuroprotective benefits from vitamin D in neurodegenerative diseases are dependent on route of administration: comparing the effect of endogenously sourced vitamin D from UV exposure to exogenously derived vitamin D through synthetic supplementation.Design: We systematically searched PubMed, Embase and PsycInfo databases which included both pre-clinical and clinical studies investigating vitamin D in neurodegenerative diseases. Articles were subject to strict inclusion criteria and objectively assessed for quality. Additionally, Medline data was analysed to identify trends in topic publications and linguistic characteristics of papers.Results: From a total of 231 screened articles, we identified 73 appropriate for review based on inclusion criteria: original studies that investigated vitamin D levels or levels of vitamin D supplementation in neurodegenerative diseases or investigated past/present sun exposure in disease cohorts. Results indicate there is insufficient evidence to comprehensively reflect on a potential neuroprotective role for vitamin D and if this was dependent on route of administration. The majority of current data supporting neuroprotective benefits from vitamin D are based on pre-clinical and observational studies. Solid evidence is lacking to support the current hypothesis that the beneficial effect of UV exposure results from the synthesis of vitamin D. Sun exposure, independent of vitamin D production, may be protective against multiple Sclerosis, Parkinson’s disease and Alzheimer’s disease. Yet, further research is required to elucidate the beneficial mechanism of actions of UV exposure. The literature of vitamin D and amyotrophic lateral sclerosis was limited, and no conclusions were drawn. Therefore, in cases where UV-derived vitamin D was hypothesized to be the beneficial mediator in the neuroprotective effects of sun exposure, we propose results are based only on associative evidence.Conclusion: On the basis of this systematic review, strong recommendations regarding therapeutic benefits of vitamin D in neurodegenerative disease cannot be made. It is unclear if vitamin D mediates a protective benefit in neurodegenerative disease or whether it is an associative marker of UV exposure, which may contribute to as of yet unidentified neuroprotective factors." @default.
• W2829413044 created "2018-07-19" @default.
• W2829413044 creator A5002156015 @default.
• W2829413044 creator A5037100405 @default.
• W2829413044 creator A5060256569 @default.
• W2829413044 creator A5078232403 @default.
• W2829413044 creator A5084494486 @default.
• W2829413044 creator A5088419634 @default.
• W2829413044 date "2018-07-09" @default.
• W2829413044 modified "2023-10-01" @default.
• W2829413044 title "Are the protective benefits of vitamin D in neurodegenerative disease dependent on route of administration? A systematic review" @default.
• W2829413044 cites W1487935461 @default.
• W2829413044 cites W1494263088 @default.
• W2829413044 cites W1504761111 @default.
• W2829413044 cites W1520038257 @default.
• W2829413044 cites W1557365633 @default.
• W2829413044 cites W1568918587 @default.
• W2829413044 cites W1599965015 @default.
• W2829413044 cites W1705522586 @default.
• W2829413044 cites W1729222511 @default.
• W2829413044 cites W1862684785 @default.
• W2829413044 cites W1934951202 @default.
• W2829413044 cites W1968152805 @default.
• W2829413044 cites W1968391535 @default.
• W2829413044 cites W1968986793 @default.
• W2829413044 cites W1972748122 @default.
• W2829413044 cites W1976776496 @default.
• W2829413044 cites W1978858100 @default.
• W2829413044 cites W1979139141 @default.
• W2829413044 cites W1979617519 @default.
• W2829413044 cites W1979952479 @default.
• W2829413044 cites W1982326735 @default.
• W2829413044 cites W1985106457 @default.
• W2829413044 cites W1985632746 @default.
• W2829413044 cites W1986319272 @default.
• W2829413044 cites W1987055095 @default.
• W2829413044 cites W1992695872 @default.
• W2829413044 cites W1994195056 @default.
• W2829413044 cites W1994409936 @default.
• W2829413044 cites W2002091683 @default.
• W2829413044 cites W2002166614 @default.
• W2829413044 cites W2002586398 @default.
• W2829413044 cites W2005286980 @default.
• W2829413044 cites W2005312443 @default.
• W2829413044 cites W2013148503 @default.
• W2829413044 cites W2013784628 @default.
• W2829413044 cites W2017664025 @default.
• W2829413044 cites W2019504350 @default.
• W2829413044 cites W2031682837 @default.
• W2829413044 cites W2034893950 @default.
• W2829413044 cites W2035934476 @default.
• W2829413044 cites W2038884667 @default.
• W2829413044 cites W2044199226 @default.
• W2829413044 cites W2056247628 @default.
• W2829413044 cites W2056304549 @default.
• W2829413044 cites W2060781047 @default.
• W2829413044 cites W2075251022 @default.
• W2829413044 cites W2077666128 @default.
• W2829413044 cites W2079852292 @default.
• W2829413044 cites W2086288529 @default.
• W2829413044 cites W2086786174 @default.
• W2829413044 cites W2086994803 @default.
• W2829413044 cites W2094747195 @default.
• W2829413044 cites W2097284781 @default.
• W2829413044 cites W2098306595 @default.
• W2829413044 cites W2099144303 @default.
• W2829413044 cites W2099630247 @default.
• W2829413044 cites W2103544702 @default.
• W2829413044 cites W2103656710 @default.
• W2829413044 cites W2104385821 @default.
• W2829413044 cites W2109909789 @default.
• W2829413044 cites W2111611699 @default.
• W2829413044 cites W2114850508 @default.
• W2829413044 cites W2115434474 @default.
• W2829413044 cites W2115880208 @default.
• W2829413044 cites W2116520267 @default.
• W2829413044 cites W2120446217 @default.
• W2829413044 cites W2121773128 @default.
• W2829413044 cites W2121933671 @default.
• W2829413044 cites W2124725201 @default.
• W2829413044 cites W2126574528 @default.
• W2829413044 cites W2127933148 @default.
• W2829413044 cites W2131851806 @default.
• W2829413044 cites W2132499228 @default.
• W2829413044 cites W2133336598 @default.
• W2829413044 cites W2134832208 @default.
• W2829413044 cites W2138675738 @default.
• W2829413044 cites W2140135481 @default.
• W2829413044 cites W2144765579 @default.
• W2829413044 cites W2146594042 @default.
• W2829413044 cites W2146805380 @default.
• W2829413044 cites W2148405577 @default.
• W2829413044 cites W2148896333 @default.
• W2829413044 cites W2149218665 @default.
• W2829413044 cites W2149387418 @default.
• W2829413044 cites W2149425411 @default.
• W2829413044 cites W2150137329 @default.
• W2829413044 cites W2150458065 @default.

• next