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- W2829596912 endingPage "3921" @default.
- W2829596912 startingPage "3906" @default.
- W2829596912 abstract "Metabolic reprogramming of cells from the innate immune system is one of the most noteworthy topics in immunological research nowadays. Upon infection or tissue damage, innate immune cells, such as macrophages, mobilize various immune and metabolic signals to mount a response best suited to eradicate the threat. Current data indicate that both the immune and metabolic responses are closely interconnected. On account of its peculiar position in regulating both of these processes, the mitochondrion has emerged as a critical organelle that orchestrates the coordinated metabolic and immune adaptations in macrophages. Significant effort is now underway to understand how metabolic features of differentiated macrophages regulate their immune specificities with the eventual goal to manipulate cellular metabolism to control immunity. In this review, we highlight some of the recent work that place cellular and mitochondrial metabolism in a central position in the macrophage differentiation program." @default.
- W2829596912 created "2018-07-19" @default.
- W2829596912 creator A5047333734 @default.
- W2829596912 creator A5048574128 @default.
- W2829596912 creator A5068932966 @default.
- W2829596912 date "2018-10-01" @default.
- W2829596912 modified "2023-10-17" @default.
- W2829596912 title "How Mitochondrial Metabolism Contributes to Macrophage Phenotype and Functions" @default.
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