FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2830007178> ?p ?o ?g. }

• W2830007178 endingPage "e1007484" @default.
• W2830007178 startingPage "e1007484" @default.
• W2830007178 abstract "Leaf growth is a complex process that involves the action of diverse transcription factors (TFs) and their downstream gene regulatory networks. In this study, we focus on the functional characterization of the Arabidopsis thaliana TF GROWTH-REGULATING FACTOR9 (GRF9) and demonstrate that it exerts its negative effect on leaf growth by activating expression of the bZIP TF OBP3-RESPONSIVE GENE 3 (ORG3). While grf9 knockout mutants produce bigger incipient leaf primordia at the shoot apex, rosette leaves and petals than the wild type, the sizes of those organs are reduced in plants overexpressing GRF9 (GRF9ox). Cell measurements demonstrate that changes in leaf size result from alterations in cell numbers rather than cell sizes. Kinematic analysis and 5-ethynyl-2'-deoxyuridine (EdU) incorporation assay revealed that GRF9 restricts cell proliferation in the early developing leaf. Performing in vitro binding site selection, we identified the 6-base motif 5'-CTGACA-3' as the core binding site of GRF9. By global transcriptome profiling, electrophoretic mobility shift assay (EMSA) and chromatin immunoprecipitation (ChIP) we identified ORG3 as a direct downstream, and positively regulated target of GRF9. Genetic analysis of grf9 org3 and GRF9ox org3 double mutants reveals that both transcription factors act in a regulatory cascade to control the final leaf dimensions by restricting cell number in the developing leaf." @default.
• W2830007178 created "2018-07-19" @default.
• W2830007178 creator A5005114470 @default.
• W2830007178 creator A5014730874 @default.
• W2830007178 creator A5055820867 @default.
• W2830007178 creator A5063332881 @default.
• W2830007178 creator A5068416995 @default.
• W2830007178 creator A5072556432 @default.
• W2830007178 date "2018-07-09" @default.
• W2830007178 modified "2023-10-14" @default.
• W2830007178 title "GROWTH-REGULATING FACTOR 9 negatively regulates arabidopsis leaf growth by controlling ORG3 and restricting cell proliferation in leaf primordia" @default.
• W2830007178 cites W128063347 @default.
• W2830007178 cites W1483671213 @default.
• W2830007178 cites W1509359129 @default.
• W2830007178 cites W1596653005 @default.
• W2830007178 cites W1933383348 @default.
• W2830007178 cites W1966685034 @default.
• W2830007178 cites W1974288404 @default.
• W2830007178 cites W1977851636 @default.
• W2830007178 cites W1978690554 @default.
• W2830007178 cites W1980085027 @default.
• W2830007178 cites W1980300422 @default.
• W2830007178 cites W1985326464 @default.
• W2830007178 cites W1986587865 @default.
• W2830007178 cites W1988904746 @default.
• W2830007178 cites W1995973955 @default.
• W2830007178 cites W1998614016 @default.
• W2830007178 cites W2002099878 @default.
• W2830007178 cites W2003935374 @default.
• W2830007178 cites W2005395625 @default.
• W2830007178 cites W2006222065 @default.
• W2830007178 cites W2008368400 @default.
• W2830007178 cites W2016774108 @default.
• W2830007178 cites W2019643071 @default.
• W2830007178 cites W2021388499 @default.
• W2830007178 cites W2024530550 @default.
• W2830007178 cites W2031492273 @default.
• W2830007178 cites W2035935598 @default.
• W2830007178 cites W2036937573 @default.
• W2830007178 cites W2039225213 @default.
• W2830007178 cites W2041874187 @default.
• W2830007178 cites W2042667559 @default.
• W2830007178 cites W2047882742 @default.
• W2830007178 cites W2048556525 @default.
• W2830007178 cites W2052704101 @default.
• W2830007178 cites W2052787486 @default.
• W2830007178 cites W2054287194 @default.
• W2830007178 cites W2056371419 @default.
• W2830007178 cites W2057135485 @default.
• W2830007178 cites W2059113522 @default.
• W2830007178 cites W2060247291 @default.
• W2830007178 cites W2060264343 @default.
• W2830007178 cites W2060687391 @default.
• W2830007178 cites W2062351978 @default.
• W2830007178 cites W2070797624 @default.
• W2830007178 cites W2071569684 @default.
• W2830007178 cites W2076807345 @default.
• W2830007178 cites W2082237426 @default.
• W2830007178 cites W2082452795 @default.
• W2830007178 cites W2084012038 @default.
• W2830007178 cites W2087328424 @default.
• W2830007178 cites W2088410574 @default.
• W2830007178 cites W2090978651 @default.
• W2830007178 cites W2094396392 @default.
• W2830007178 cites W2096342347 @default.
• W2830007178 cites W2100169554 @default.
• W2830007178 cites W2103272211 @default.
• W2830007178 cites W2105595936 @default.
• W2830007178 cites W2107021214 @default.
• W2830007178 cites W2109980254 @default.
• W2830007178 cites W2111025355 @default.
• W2830007178 cites W2111739512 @default.
• W2830007178 cites W2112800334 @default.
• W2830007178 cites W2114437852 @default.
• W2830007178 cites W2114570899 @default.
• W2830007178 cites W2115190641 @default.
• W2830007178 cites W2118151616 @default.
• W2830007178 cites W2119906556 @default.
• W2830007178 cites W2120245260 @default.
• W2830007178 cites W2121089588 @default.
• W2830007178 cites W2124079890 @default.
• W2830007178 cites W2127204797 @default.
• W2830007178 cites W2128720044 @default.
• W2830007178 cites W2129578940 @default.
• W2830007178 cites W2129847122 @default.
• W2830007178 cites W2131463690 @default.
• W2830007178 cites W2133130447 @default.
• W2830007178 cites W2133353275 @default.
• W2830007178 cites W2133955384 @default.
• W2830007178 cites W2136421700 @default.
• W2830007178 cites W2136855238 @default.
• W2830007178 cites W2137138997 @default.
• W2830007178 cites W2140677456 @default.
• W2830007178 cites W2141344574 @default.
• W2830007178 cites W2141389812 @default.
• W2830007178 cites W2142904225 @default.
• W2830007178 cites W2143883584 @default.
• W2830007178 cites W2145444730 @default.

• next