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- W2830852884 endingPage "402" @default.
- W2830852884 startingPage "390" @default.
- W2830852884 abstract "The higher consumption of fruit, herbs, spices, and vegetables is well known and practical strategy to cure human cancers owing to their presence of bioactive compounds. Among these, Nigella sativa is a promising source of bioactive compounds including thymoquinone, monoterpenes, p-cymene and α-piene etc. Thymoquinone has been found effective to inhibit the different cancer stages such as proliferation, migration and invasion. It also acts as anticancer agent against different human cancers such as breast, pancreatic, prostate, blood, oral, bone, head and neck, cervical, liver and lung. It significantly mediated miR-34a up-regulation, enhanced the levels of miR-34a through p53, and down controlled Rac1 expression. Thymoquinone induces apoptosis, regulates the levels of pro- and anti- apoptotic genes. It also has been known to lower the phosphorylation of NF-κB and IKKα/β and reduces the metastasis as well as also lowered the ERK1/2 and PI3K activities. Thymoquinone inhibits the metastasis through activation of JNK and p38. The present review article highlights the anticancer perspectives of thymoquinone in human by various pathways and use of this compound as diet based therapy has proven new pharmacological agent against several types of cancers." @default.
- W2830852884 created "2018-07-19" @default.
- W2830852884 creator A5003348433 @default.
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- W2830852884 creator A5055984147 @default.
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- W2830852884 creator A5077446152 @default.
- W2830852884 date "2018-10-01" @default.
- W2830852884 modified "2023-10-07" @default.
- W2830852884 title "Thymoquinone: A novel strategy to combat cancer: A review" @default.
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