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- W2833997834 abstract "Abstract Effective derivation of three-dimensional (3D) retinal tissue from human-induced pluripotent stem cells (hiPSCs) could provide models for drug screening and facilitate patient-specific retinal cell replacement therapy. However, some hiPSC lines cannot undergo 3D self-organization and show inadequate differentiation efficiency to meet clinical demand. In this study, we developed an optimized system for derivation of 3D retinal tissue. We found that the Wnt signaling pathway antagonist Dickkopf-related protein 1 (DKK-1) rescued the inability of differentiated retinal progenitors to self-organize. By evaluating DKK-1 expression and supplying DKK-1 if necessary, retinal organoids were differentiated from six hiPSC lines, which were reprogramed from three common initiating cell types. Retinal tissues derived from the optimized system were well organized and capable of surviving for further maturation. Thus, using this system, we generated retinal tissues from various hiPSC lines with high efficiency. This novel system has many potential applications in regenerative therapy and precision medicine." @default.
- W2833997834 created "2018-07-19" @default.
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- W2833997834 date "2018-09-08" @default.
- W2833997834 modified "2023-10-16" @default.
- W2833997834 title "An Optimized System for Effective Derivation of Three-Dimensional Retinal Tissue via Wnt Signaling Regulation" @default.
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- W2833997834 doi "https://doi.org/10.1002/stem.2890" @default.
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