FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W28341886> ?p ?o ?g. }

• W28341886 abstract "Non-small cell lung cancer (NSCLC) is a malignant tumour with quite high cancer specific mortality, and it still lacks stable and reliable markers for NSCLC's prognosis. Platelet derived grow factor (PDGF) and PDGFR has been considered to be involved in the process of cell proliferation, migration, metastasis and epithelial mesenchymal transition of cancer cell through various intracellular signal pathways. Pathology analysis showed that PDGF pathway mainly stimulates the proliferation of NSCLC tumour stroma through paracrine pattern, and some reaseach found that PDGF pathway directly promotes some NSCLC cell's proliferation. The expression of PDGF and PDGFR within NSCLC tissue correlates with status of lymphatic metastasis and patients' prognosis. In clinical treatment of NSCLC, the great effect of PDGF pathway in angiogenesis and promoting distribution of chemotherapy by inhibition of PDGF should not be neglected. As an important pro-angiogenesis pathway, functions of PDGF in radiotherapy is dicovered by more and more fundamental research. This review focuses on the progress of PDGF pathway in NSCLC and aims to provide some new ideas for clinical and fundamental researchers.非小细胞肺癌（non-small cell lung cancer, NSCLC）作为全球癌症相关死亡率较高的恶性肿瘤，目前仍缺少可靠稳定的预后指标。血小板源生长因子（platelet derived grow factor, PDGF）及其受体通过多种细胞内信号通路参与细胞生长，迁移，转移以及上皮间叶转化等过程。病理结果表明，PDGF通路主要通过旁分泌途径刺激NSCLC肿瘤间质生长，亦有发现PDGF通路对某些NSCLC肿瘤细胞可能存在直接驱动作用。NSCLC组织中的PDGF及其受体的表达与肿瘤的预后，淋巴结转移等临床结果相关。在临床治疗中，PDGF通路对NSCLC血管生成的重要作用，及抑制PDGF通路促进化疗药物在实体瘤内部分布的作用不容忽视。PDGF作为重要的促血管生成通路，在NSCLC放射治疗中的作用也越来越多地被各种基础研究证实。本文拟对PDGF通路在NSCLC领域的研究进展做一综述，以求对临床和基础研究者有一些启发。" @default.
• W28341886 created "2016-06-24" @default.
• W28341886 creator A5045483608 @default.
• W28341886 creator A5052142926 @default.
• W28341886 creator A5055761984 @default.
• W28341886 date "2014-01-01" @default.
• W28341886 modified "2023-10-14" @default.
• W28341886 title "[Progress of platelet derived grow factor family in non-small cell lung cancer]." @default.
• W28341886 cites W1485397102 @default.
• W28341886 cites W1487831133 @default.
• W28341886 cites W1538049069 @default.
• W28341886 cites W1843891279 @default.
• W28341886 cites W1968338321 @default.
• W28341886 cites W1978125996 @default.
• W28341886 cites W1991781559 @default.
• W28341886 cites W1996515934 @default.
• W28341886 cites W2002606479 @default.
• W28341886 cites W2013540568 @default.
• W28341886 cites W2014075906 @default.
• W28341886 cites W2015338496 @default.
• W28341886 cites W2028001877 @default.
• W28341886 cites W2028220971 @default.
• W28341886 cites W2028849325 @default.
• W28341886 cites W2039567630 @default.
• W28341886 cites W2046538477 @default.
• W28341886 cites W2049184800 @default.
• W28341886 cites W2053241578 @default.
• W28341886 cites W2058707578 @default.
• W28341886 cites W2063084845 @default.
• W28341886 cites W2067699525 @default.
• W28341886 cites W2071756208 @default.
• W28341886 cites W2077565372 @default.
• W28341886 cites W2079347556 @default.
• W28341886 cites W2093727585 @default.
• W28341886 cites W2093775484 @default.
• W28341886 cites W2100917720 @default.
• W28341886 cites W2101398318 @default.
• W28341886 cites W2101947487 @default.
• W28341886 cites W2102996502 @default.
• W28341886 cites W2112524831 @default.
• W28341886 cites W2113447234 @default.
• W28341886 cites W2131932020 @default.
• W28341886 cites W2134615815 @default.
• W28341886 cites W2138088489 @default.
• W28341886 cites W2141632229 @default.
• W28341886 cites W2144187094 @default.
• W28341886 cites W2151200446 @default.
• W28341886 cites W2152298532 @default.
• W28341886 doi "https://doi.org/10.3779/j.issn.1009-3419.2014.01.07" @default.
• W28341886 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6000208" @default.
• W28341886 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24398313" @default.
• W28341886 hasPublicationYear "2014" @default.
• W28341886 type Work @default.
• W28341886 sameAs 28341886 @default.
• W28341886 citedByCount "0" @default.
• W28341886 crossrefType "journal-article" @default.
• W28341886 hasAuthorship W28341886A5045483608 @default.
• W28341886 hasAuthorship W28341886A5052142926 @default.
• W28341886 hasAuthorship W28341886A5055761984 @default.
• W28341886 hasConcept C121608353 @default.
• W28341886 hasConcept C126322002 @default.
• W28341886 hasConcept C143998085 @default.
• W28341886 hasConcept C170493617 @default.
• W28341886 hasConcept C180361614 @default.
• W28341886 hasConcept C2775960820 @default.
• W28341886 hasConcept C2776256026 @default.
• W28341886 hasConcept C2779013556 @default.
• W28341886 hasConcept C2780394083 @default.
• W28341886 hasConcept C2781294074 @default.
• W28341886 hasConcept C502942594 @default.
• W28341886 hasConcept C71924100 @default.
• W28341886 hasConcept C7876069 @default.
• W28341886 hasConcept C86803240 @default.
• W28341886 hasConceptScore W28341886C121608353 @default.
• W28341886 hasConceptScore W28341886C126322002 @default.
• W28341886 hasConceptScore W28341886C143998085 @default.
• W28341886 hasConceptScore W28341886C170493617 @default.
• W28341886 hasConceptScore W28341886C180361614 @default.
• W28341886 hasConceptScore W28341886C2775960820 @default.
• W28341886 hasConceptScore W28341886C2776256026 @default.
• W28341886 hasConceptScore W28341886C2779013556 @default.
• W28341886 hasConceptScore W28341886C2780394083 @default.
• W28341886 hasConceptScore W28341886C2781294074 @default.
• W28341886 hasConceptScore W28341886C502942594 @default.
• W28341886 hasConceptScore W28341886C71924100 @default.
• W28341886 hasConceptScore W28341886C7876069 @default.
• W28341886 hasConceptScore W28341886C86803240 @default.
• W28341886 hasLocation W283418861 @default.
• W28341886 hasLocation W283418862 @default.
• W28341886 hasOpenAccess W28341886 @default.
• W28341886 hasPrimaryLocation W283418861 @default.
• W28341886 hasRelatedWork W1984583460 @default.
• W28341886 hasRelatedWork W2025842270 @default.
• W28341886 hasRelatedWork W2099619041 @default.
• W28341886 hasRelatedWork W2173917538 @default.
• W28341886 hasRelatedWork W2315114303 @default.
• W28341886 hasRelatedWork W2811434284 @default.
• W28341886 hasRelatedWork W2892707925 @default.
• W28341886 hasRelatedWork W2908335280 @default.
• W28341886 hasRelatedWork W4283771460 @default.

• next