Matches in SemOpenAlex for { <https://semopenalex.org/work/W2835153656> ?p ?o ?g. }
- W2835153656 abstract "Significance The transcription coactivator LEDGF/p75 contributes to regulation of gene expression by tethering other factors to actively transcribed genes on chromatin. Its chromatin-tethering activity is hijacked in two important disease settings, HIV and mixed-lineage leukemia; however, the basis for the biological regulation of LEDGF/p75’s interaction to binding partners has remained unknown. This has represented a gap in our understanding of LEDGF/p75’s fundamental biological function and a major limitation for development of therapeutic targeting of LEDGF/p75 in human disease. Our work provides a mechanistic understanding of how the lens epithelium-derived growth factor interaction network is regulated at the molecular level." @default.
- W2835153656 created "2018-07-19" @default.
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- W2835153656 date "2018-07-11" @default.
- W2835153656 modified "2023-10-18" @default.
- W2835153656 title "Affinity switching of the LEDGF/p75 IBD interactome is governed by kinase-dependent phosphorylation" @default.
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- W2835153656 cites W1964170347 @default.
- W2835153656 cites W1968153105 @default.
- W2835153656 cites W1973466091 @default.
- W2835153656 cites W1974515407 @default.
- W2835153656 cites W1975150670 @default.
- W2835153656 cites W1976600302 @default.
- W2835153656 cites W1981367752 @default.
- W2835153656 cites W1981387221 @default.
- W2835153656 cites W1981493445 @default.
- W2835153656 cites W1985711767 @default.
- W2835153656 cites W1992915932 @default.
- W2835153656 cites W1993148712 @default.
- W2835153656 cites W1997267233 @default.
- W2835153656 cites W2002073949 @default.
- W2835153656 cites W2004688558 @default.
- W2835153656 cites W2006529234 @default.
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- W2835153656 cites W2008902252 @default.
- W2835153656 cites W2011430819 @default.
- W2835153656 cites W2017985095 @default.
- W2835153656 cites W2023149772 @default.
- W2835153656 cites W2023461806 @default.
- W2835153656 cites W2025570007 @default.
- W2835153656 cites W2027241628 @default.
- W2835153656 cites W2029099543 @default.
- W2835153656 cites W2030040354 @default.
- W2835153656 cites W2030606608 @default.
- W2835153656 cites W2033964251 @default.
- W2835153656 cites W2035965301 @default.
- W2835153656 cites W2038816853 @default.
- W2835153656 cites W2040182924 @default.
- W2835153656 cites W2048168473 @default.
- W2835153656 cites W2051288343 @default.
- W2835153656 cites W2059636071 @default.
- W2835153656 cites W2068972095 @default.
- W2835153656 cites W2070330288 @default.
- W2835153656 cites W2076768032 @default.
- W2835153656 cites W2082485360 @default.
- W2835153656 cites W2082592723 @default.
- W2835153656 cites W2083292764 @default.
- W2835153656 cites W2085759082 @default.
- W2835153656 cites W2088335428 @default.
- W2835153656 cites W2088938650 @default.
- W2835153656 cites W2094799740 @default.
- W2835153656 cites W2095184701 @default.
- W2835153656 cites W2096275987 @default.
- W2835153656 cites W2098613471 @default.
- W2835153656 cites W2103328294 @default.
- W2835153656 cites W2103931447 @default.
- W2835153656 cites W2106494657 @default.
- W2835153656 cites W2123317697 @default.
- W2835153656 cites W2123810432 @default.
- W2835153656 cites W2125248088 @default.
- W2835153656 cites W2128456899 @default.
- W2835153656 cites W2132900722 @default.
- W2835153656 cites W2140812363 @default.
- W2835153656 cites W2152635758 @default.
- W2835153656 cites W2157646587 @default.
- W2835153656 cites W2157658519 @default.
- W2835153656 cites W2159701805 @default.
- W2835153656 cites W2171975491 @default.
- W2835153656 cites W2238514531 @default.
- W2835153656 cites W2258942936 @default.
- W2835153656 cites W2291183135 @default.
- W2835153656 cites W2310066925 @default.
- W2835153656 cites W2332712348 @default.
- W2835153656 cites W2395887422 @default.
- W2835153656 cites W2474635760 @default.
- W2835153656 cites W2558450893 @default.
- W2835153656 cites W2741053548 @default.
- W2835153656 cites W2760129444 @default.
- W2835153656 doi "https://doi.org/10.1073/pnas.1803909115" @default.
- W2835153656 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6065015" @default.