Matches in SemOpenAlex for { <https://semopenalex.org/work/W2835226147> ?p ?o ?g. }
- W2835226147 endingPage "1194.e5" @default.
- W2835226147 startingPage "1185" @default.
- W2835226147 abstract "While traditional drug discovery continues to be an important platform for the search of new antibiotics, alternative approaches should also be pursued to complement these efforts. We herein designed a class of molecules that decorate bacterial cell surfaces with the goal of re-engaging components of the immune system toward Escherichia coli and Pseudomonas aeruginosa. More specifically, conjugates were assembled using polymyxin B (an antibiotic that inherently attaches to the surface of Gram-negative pathogens) and antigenic epitopes that recruit antibodies found in human serum. We established that the spacer length played a significant role in hapten display within the bacterial cell surface, a result that was confirmed both experimentally and via molecular dynamics simulations. Most importantly, we demonstrated the specific killing of bacteria by our agent in the presence of human serum. By enlisting the immune system, these agents have the potential to pave the way for a potent antimicrobial modality." @default.
- W2835226147 created "2018-07-19" @default.
- W2835226147 creator A5009759926 @default.
- W2835226147 creator A5010167341 @default.
- W2835226147 creator A5025721506 @default.
- W2835226147 creator A5030884127 @default.
- W2835226147 creator A5035010158 @default.
- W2835226147 creator A5039005001 @default.
- W2835226147 creator A5042720391 @default.
- W2835226147 creator A5049205269 @default.
- W2835226147 creator A5071236503 @default.
- W2835226147 date "2018-10-01" @default.
- W2835226147 modified "2023-10-16" @default.
- W2835226147 title "Synthetic Immunotherapeutics against Gram-negative Pathogens" @default.
- W2835226147 cites W1442200272 @default.
- W2835226147 cites W1504680783 @default.
- W2835226147 cites W1531521794 @default.
- W2835226147 cites W1700549773 @default.
- W2835226147 cites W1895129045 @default.
- W2835226147 cites W1964482783 @default.
- W2835226147 cites W1969493239 @default.
- W2835226147 cites W1970798262 @default.
- W2835226147 cites W1971116536 @default.
- W2835226147 cites W1974016827 @default.
- W2835226147 cites W1974216005 @default.
- W2835226147 cites W1979593019 @default.
- W2835226147 cites W1986237818 @default.
- W2835226147 cites W1990771438 @default.
- W2835226147 cites W1992542859 @default.
- W2835226147 cites W1992699637 @default.
- W2835226147 cites W1997971441 @default.
- W2835226147 cites W2006365556 @default.
- W2835226147 cites W2010970338 @default.
- W2835226147 cites W2012092762 @default.
- W2835226147 cites W2021520922 @default.
- W2835226147 cites W2052575942 @default.
- W2835226147 cites W2053095874 @default.
- W2835226147 cites W2054086212 @default.
- W2835226147 cites W2061481549 @default.
- W2835226147 cites W2061658534 @default.
- W2835226147 cites W2069796080 @default.
- W2835226147 cites W2072174052 @default.
- W2835226147 cites W2072760270 @default.
- W2835226147 cites W2078785671 @default.
- W2835226147 cites W2080042107 @default.
- W2835226147 cites W2091672290 @default.
- W2835226147 cites W2100398499 @default.
- W2835226147 cites W2107050135 @default.
- W2835226147 cites W2111667046 @default.
- W2835226147 cites W2117795567 @default.
- W2835226147 cites W2119921534 @default.
- W2835226147 cites W2120227455 @default.
- W2835226147 cites W2123219111 @default.
- W2835226147 cites W2124140010 @default.
- W2835226147 cites W2130626443 @default.
- W2835226147 cites W2131392955 @default.
- W2835226147 cites W2139974712 @default.
- W2835226147 cites W2143295328 @default.
- W2835226147 cites W2150188452 @default.
- W2835226147 cites W2150981663 @default.
- W2835226147 cites W2160834915 @default.
- W2835226147 cites W2162923011 @default.
- W2835226147 cites W2168269595 @default.
- W2835226147 cites W2277949932 @default.
- W2835226147 cites W2296621547 @default.
- W2835226147 cites W2303509653 @default.
- W2835226147 cites W2312501736 @default.
- W2835226147 cites W2313268045 @default.
- W2835226147 cites W2414669751 @default.
- W2835226147 cites W2518296845 @default.
- W2835226147 cites W2560367415 @default.
- W2835226147 cites W2564298127 @default.
- W2835226147 cites W2576205983 @default.
- W2835226147 cites W2582899954 @default.
- W2835226147 cites W2593939403 @default.
- W2835226147 cites W2611449600 @default.
- W2835226147 cites W852562599 @default.
- W2835226147 doi "https://doi.org/10.1016/j.chembiol.2018.05.019" @default.
- W2835226147 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6195440" @default.
- W2835226147 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29983273" @default.
- W2835226147 hasPublicationYear "2018" @default.
- W2835226147 type Work @default.
- W2835226147 sameAs 2835226147 @default.
- W2835226147 citedByCount "27" @default.
- W2835226147 countsByYear W28352261472018 @default.
- W2835226147 countsByYear W28352261472019 @default.
- W2835226147 countsByYear W28352261472020 @default.
- W2835226147 countsByYear W28352261472021 @default.
- W2835226147 countsByYear W28352261472022 @default.
- W2835226147 countsByYear W28352261472023 @default.
- W2835226147 crossrefType "journal-article" @default.
- W2835226147 hasAuthorship W2835226147A5009759926 @default.
- W2835226147 hasAuthorship W2835226147A5010167341 @default.
- W2835226147 hasAuthorship W2835226147A5025721506 @default.
- W2835226147 hasAuthorship W2835226147A5030884127 @default.
- W2835226147 hasAuthorship W2835226147A5035010158 @default.
- W2835226147 hasAuthorship W2835226147A5039005001 @default.
- W2835226147 hasAuthorship W2835226147A5042720391 @default.