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- W2835385369 endingPage "226" @default.
- W2835385369 startingPage "191" @default.
- W2835385369 abstract "Synthetic cannabinoid receptor agonists (SCRAs) are the largest and most structurally diverse class of new psychoactive substances (NPS). Although the earliest SCRA NPS were simply repurposed from historical academic manuscripts or pharmaceutical patents describing cannabinoid ligands, recent examples bear hallmarks of rational design. SCRA NPS manufacturers have applied traditional medicinal chemistry strategies (such as molecular hybridization, bioisosteric replacement, and scaffold hopping) to existing cannabinoid templates in order to generate new molecules that circumvent structure-based legislation. Most SCRAs potently activate cannabinoid type 1 and type 2 receptors (CB1 and CB2, respectively), with the former contributing to the psychoactivity of these substances. SCRAs are generally more toxic than the Δ9-tetrahydrocannabinol (Δ9-THC) found in cannabis, and this may be due to ligand bias, metabolism, or off-target activity. This chapter will chart the evolution of recently identified SCRA NPS chemotypes, as well as their putative manufacturing by-products and thermolytic degradants, and describe structure-activity relationships within each class." @default.
- W2835385369 created "2018-07-19" @default.
- W2835385369 creator A5010714266 @default.
- W2835385369 creator A5043067912 @default.
- W2835385369 date "2018-01-01" @default.
- W2835385369 modified "2023-09-24" @default.
- W2835385369 title "The Chemistry and Pharmacology of Synthetic Cannabinoid Receptor Agonist New Psychoactive Substances: Evolution" @default.
- W2835385369 cites W1536445278 @default.
- W2835385369 cites W1581272510 @default.
- W2835385369 cites W1693923539 @default.
- W2835385369 cites W1860194048 @default.
- W2835385369 cites W1899851239 @default.
- W2835385369 cites W1929410648 @default.
- W2835385369 cites W1932361318 @default.
- W2835385369 cites W1951955101 @default.
- W2835385369 cites W1968629237 @default.
- W2835385369 cites W1969900449 @default.
- W2835385369 cites W1973544026 @default.
- W2835385369 cites W1976981359 @default.
- W2835385369 cites W1982523380 @default.
- W2835385369 cites W1989151397 @default.
- W2835385369 cites W1990396144 @default.
- W2835385369 cites W1997307027 @default.
- W2835385369 cites W2000877461 @default.
- W2835385369 cites W2004455574 @default.
- W2835385369 cites W2007570523 @default.
- W2835385369 cites W2017729185 @default.
- W2835385369 cites W2021178430 @default.
- W2835385369 cites W2022547474 @default.
- W2835385369 cites W2023918022 @default.
- W2835385369 cites W2029811071 @default.
- W2835385369 cites W2034861596 @default.
- W2835385369 cites W2036470103 @default.
- W2835385369 cites W2038784126 @default.
- W2835385369 cites W2039952070 @default.
- W2835385369 cites W2041471692 @default.
- W2835385369 cites W2041629720 @default.
- W2835385369 cites W2042192948 @default.
- W2835385369 cites W2043685462 @default.
- W2835385369 cites W2043913134 @default.
- W2835385369 cites W2043933291 @default.
- W2835385369 cites W2046989195 @default.
- W2835385369 cites W2056472275 @default.
- W2835385369 cites W2056989403 @default.
- W2835385369 cites W2058003924 @default.
- W2835385369 cites W2060048989 @default.
- W2835385369 cites W2063808330 @default.
- W2835385369 cites W2070874444 @default.
- W2835385369 cites W2071460611 @default.
- W2835385369 cites W2071507001 @default.
- W2835385369 cites W2071568757 @default.
- W2835385369 cites W2071983598 @default.
- W2835385369 cites W2074114778 @default.
- W2835385369 cites W2076328278 @default.
- W2835385369 cites W2079082493 @default.
- W2835385369 cites W2085313140 @default.
- W2835385369 cites W2086791578 @default.
- W2835385369 cites W2086923941 @default.
- W2835385369 cites W2088141919 @default.
- W2835385369 cites W2090907902 @default.
- W2835385369 cites W2091943716 @default.
- W2835385369 cites W2094072348 @default.
- W2835385369 cites W2105155753 @default.
- W2835385369 cites W2113134077 @default.
- W2835385369 cites W2114691708 @default.
- W2835385369 cites W2123211988 @default.
- W2835385369 cites W2124685081 @default.
- W2835385369 cites W2129112276 @default.
- W2835385369 cites W2131899215 @default.
- W2835385369 cites W2147073785 @default.
- W2835385369 cites W2153539777 @default.
- W2835385369 cites W2156311335 @default.
- W2835385369 cites W2166554816 @default.
- W2835385369 cites W2172891866 @default.
- W2835385369 cites W2178564482 @default.
- W2835385369 cites W2186697446 @default.
- W2835385369 cites W2211532326 @default.
- W2835385369 cites W2220260933 @default.
- W2835385369 cites W2220587844 @default.
- W2835385369 cites W2258386272 @default.
- W2835385369 cites W2280379376 @default.
- W2835385369 cites W2282957749 @default.
- W2835385369 cites W2296751402 @default.
- W2835385369 cites W2305739639 @default.
- W2835385369 cites W2306386326 @default.
- W2835385369 cites W2308080184 @default.
- W2835385369 cites W2325417207 @default.
- W2835385369 cites W2326889891 @default.
- W2835385369 cites W2333790536 @default.
- W2835385369 cites W2334189569 @default.
- W2835385369 cites W2404390137 @default.
- W2835385369 cites W2409722113 @default.
- W2835385369 cites W2412463543 @default.
- W2835385369 cites W2460822131 @default.
- W2835385369 cites W2461445814 @default.
- W2835385369 cites W2463609465 @default.
- W2835385369 cites W2464160437 @default.
- W2835385369 cites W2470236573 @default.