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• W2835568129 abstract "The cause of biliary atresia (BA) remains an enigma. However, an ethnic diversity in the incidence of BA is so unique that anthropological approach may provide some etiopathogenetic implications in the disease mechanism. We previously reported that an association of maternal microchimerism (MMc) in BA and a significant compatibility of HLA-A between the patient with BA and their mother. Across the 10 countries (Japan, South Korea, Taiwan, Philippines, New Zealand (Maori population), UK, France, Germany, Norway, and Sweden), we determined the frequency of the most prevalent HLA haplotypes of each country from Allele Frequency Database and found that it was significantly correlated with the incidence of BA of the respective country (p = 0.0126). This observation better fits the MMc theory as an etiopathogenesis, that is, maternal effector cells are likely to migrate into the fetus in a relatively homogenous population and may damage the developing bile duct structure and portal vein endothelium, depending on materno-fetal tolerance and immunity." @default.
• W2835568129 created "2018-07-19" @default.
• W2835568129 creator A5050969230 @default.
• W2835568129 creator A5073548991 @default.
• W2835568129 creator A5086933017 @default.
• W2835568129 date "2018-09-01" @default.
• W2835568129 modified "2023-10-04" @default.
• W2835568129 title "Ethnic variation in the incidence of biliary atresia correlates with the frequency of the most prevalent haplotype in its population" @default.
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• W2835568129 doi "https://doi.org/10.1016/j.humimm.2018.07.001" @default.
• W2835568129 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30006139" @default.
• W2835568129 hasPublicationYear "2018" @default.
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